公开(公告)号：US20150110824A1

公开(公告)日：2015-04-23

申请号：US14385813

申请日：2013-03-18

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： Brigitte Desiree Alberte Colau ,  Sandra Giannini ,  Laurence Lockman

IPC: A61K39/39 ,  C12N7/00 ,  A61K39/12

CPC classification number: A61K39/39 ,  A61K39/12 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/55572 ,  C12N7/00 ,  C12N2710/20023 ,  C12N2710/20034 ,  C12N2710/20071

Abstract: The disclosure provides immunogenic compositions comprising HPV VLPs from one or more HPV types in combination with an adjuvant comprising a TLR agonist for use in a method for the prevention of HPV infection or disease in an individual, wherein a first dose of the immunogenic composition comprising HPV VLPs and a TLR agonist, is administered followed by a second dose of an immunogenic composition comprising HPV VLPs from one or more HPV types but which does not comprise a TLR agonist.

Abstract translation: 本公开提供了包含来自一种或多种HPV类型的HPV VLP与包含用于预防个体的HPV感染或疾病的方法的TLR激动剂的佐剂的免疫原性组合物，其中包含HPV的免疫原性组合物的第一剂量 VLP和TLR激动剂，然后施用第二剂量的包含来自一种或多种HPV类型但不包含TLR激动剂的HPV VLP的免疫原性组合物。