公开(公告)号：US20230364214A1

公开(公告)日：2023-11-16

申请号：US18305948

申请日：2023-04-24

申请人： GLAXOSMITHKLINE BIOLOGICALS S.A.

发明人： Michael T. KOWARIK ,  Michael L. WETTER ,  Stefan J. KEMMLER ,  Micha A. HÄUPTLE ,  Veronica GAMBILLARA ,  Manuela MALLY

IPC分类号： A61K39/108 ,  A61K39/02 ,  C08B37/00 ,  A61K47/64 ,  C07K14/21

CPC分类号： A61K39/0258 ,  A61K39/02 ,  C08B37/0063 ,  C08B37/0066 ,  A61K47/646 ,  C07K14/21 ,  C07K14/245

摘要： Provided herein is an E. coli O polysaccharide, O25B. Also provided herein are prokaryotic host cells containing enzymes (e.g., glycosyltransferases) used in O25B production. The host cells provided herein produce O25B bioconjugates, wherein said bioconjugates contain O25B linked to a carrier protein. Further provided herein are compositions, e.g., pharmaceutical compositions, including O25B and/or bioconjugates containing O25B. Such compositions can be used as vaccines against infection with ExPEC, and may further include one or more additional bioconjugates.

公开(公告)号：US20210154286A1

公开(公告)日：2021-05-27

申请号：US17165333

申请日：2021-02-02

申请人： GLAXOSMITHKLINE BIOLOGICALS S.A.

发明人： Michael T. KOWARIK ,  Michael L. WETTER ,  Stefan J. KEMMLER ,  Micha A. HÄUPTLE ,  Veronica GAMBILLARA ,  Manuela MALLY

IPC分类号： A61K39/108 ,  A61K39/02 ,  C08B37/00 ,  A61K47/64 ,  C07K14/21

摘要： Provided herein is an E. coli O polysaccharide, O25B. Also provided herein are prokaryotic host cells containing enzymes (e.g., glycosyltransferases) used in O25B production. The host cells provided herein produce O25B bioconjugates, wherein said bioconjugates contain O25B linked to a carrier protein. Further provided herein are compositions, e.g., pharmaceutical compositions, including O25B and/or bioconjugates containing O25B. Such compositions can be used as vaccines against infection with ExPEC, and may further include one or more additional bioconjugates.