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公开(公告)号：US20180353600A1
公开(公告)日：2018-12-13
申请号：US16062300
申请日：2016-12-21
发明人： Fabio GRASSI , Michele PROIETTI
IPC分类号： A61K39/39 , A61K39/108 , A61K39/112 , A61K9/51 , A61P31/18 , A61P37/04
CPC分类号： A61K39/39 , A61K9/51 , A61K38/53 , A61K39/0258 , A61K39/0275 , A61K2039/55516 , A61K2039/57 , A61P31/18 , A61P37/04 , Y02A50/463 , Y02A50/465 , Y02A50/469 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/481 , Y02A50/491
摘要： Compositions capable of enhancing and/or eliciting an immune response in a subject and methods of using the compositions. The compositions are capable of enhancing an IgA immune response and/or an IgG immune response and comprise an agent capable of reducing the level of binding of ATP to a P2X7 receptor to a subject. The compositions are for oral administration.
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公开(公告)号：US09999600B2
公开(公告)日：2018-06-19
申请号：US15362476
申请日：2016-11-28
申请人： N-Fold LLC
发明人： Howard B. Sosin , Michael J. Caplan
IPC分类号： A61K9/51 , A61K39/35 , A61K9/50 , A61K39/02 , A61K39/145 , A61K39/39 , C12N7/00 , A61K39/108 , A61K39/00
CPC分类号： A61K9/5153 , A61K9/5031 , A61K9/5176 , A61K39/025 , A61K39/0258 , A61K39/145 , A61K39/35 , A61K39/39 , A61K2039/5258 , A61K2039/54 , A61K2039/542 , A61K2039/545 , A61K2039/55511 , A61K2039/55516 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/55594 , A61K2039/57 , C12N7/00 , C12N2760/16034 , Y02A50/386 , Y02A50/388 , Y02A50/394 , Y02A50/401 , Y02A50/41 , Y02A50/412 , Y02A50/414 , Y02A50/416
摘要： The present invention provides, among other things, nanoparticle compositions including a plurality of nanoparticles, each of which is comprised of a biodegradable or biocompatible polymer arranged in a nanoparticle structure defining an internal lumen and an external surface and one or more of a preparation of hydrophilic cellular components and a preparation of hydrophobic cellular components. In some embodiments, the preparation of hydrophilic cellular components is encapsulated within the internal lumen and the preparation of hydrophobic cellular components is associated with the external surface. Various methods of making and using disclosed nanoparticle compositions are also provided.
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公开(公告)号：US09981027B2
公开(公告)日：2018-05-29
申请号：US15039697
申请日：2014-11-25
发明人： Kazutoshi Sawada , Takeshi Matsui , Eiji Takita , Takashi Hamabata , Toshio Sato
IPC分类号： A23K50/30 , A61K39/112 , C07K14/245 , C07K14/25 , A61K39/108 , A61K38/16 , A23K20/00 , A61K39/00
CPC分类号： A61K39/0283 , A23K20/00 , A23K50/30 , A61K38/164 , A61K39/0258 , A61K2039/542 , A61K2039/552 , C07K14/245 , C07K14/25 , C07K2319/00 , Y02A50/474
摘要： The present invention provides an agent for controlling colibacillosis including a fusion protein comprising a subunit of Shiga toxin and a subunit of Escherichia coli heat-labile toxin.
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4.发明申请公开(公告)号：US20180117131A1
公开(公告)日：2018-05-03
申请号：US15802350
申请日：2017-11-02
发明人： Michael Hess , Petra Ganas
IPC分类号： A61K39/002 , C12N1/36 , C12N1/20 , C12N1/10 , A61K39/108 , A61K39/00
CPC分类号： A61K39/002 , A61K39/00 , A61K39/0258 , C12N1/10 , C12N1/20 , C12N1/36
摘要： The invention discloses a method for producing a single bacterial strain culture of Histomonas meleagridis (H. meleagridis), the method being characterised by the following steps: (a) providing a xenic culture of H. meleagridis comprising H. meleagridis cells with a wild type bacterial flora, (b) treating the xenic culture with a mixture of antibiotics thereby killing the wild type bacterial flora, (c) centrifuging and washing the H. meleagridis cells, (d) controlling effectiveness of step (b), (e) resuspending the washed H. meleagridis cells, (f) adding one or more single bacterial strain(s) to the resuspended H. meleagridis cells, and (g) culturing the one or more single bacterial strain(s) with the resuspended H. meleagridis cells so as to obtain a single bacterial strain culture of H. meleagridis. The invention further discloses a vaccine formulation consisting of a Histomonas component consisting of an attenuated culture of Histomonas meleagridis, a bacterial component consisting of one or more cultures of a single bacterial strain, and pharmaceutically acceptable non-biological formulation compounds.
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公开(公告)号：US09931390B2
公开(公告)日：2018-04-03
申请号：US15247297
申请日：2016-08-25
IPC分类号： A61K35/747 , A61K39/108 , A61K35/744 , A23L33/135 , A61K39/00
CPC分类号： A61K39/0258 , A23L33/135 , A23V2002/00 , A61K35/744 , A61K35/747 , A61K2039/523 , A61K2039/58 , Y02A50/474
摘要： The present disclosure relates generally to therapeutic compositions comprising recombinant bacteria. Further, the disclosure elaborates upon methods of utilizing the taught therapeutic compositions to treat autoimmune and inflammatory disease. The present teachings also relate to the disclosed recombinant bacteria and methods of producing the recombinant bacteria utilized in the compositions and methods. Further taught herein are dietary supplements and food additive compositions comprising the taught recombinant bacteria.
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公开(公告)号：US20170354727A1
公开(公告)日：2017-12-14
申请号：US15684355
申请日：2017-08-23
申请人： The Government of the USA as represented by the Secretary of the Dept. of Health and Human Service
IPC分类号： A61K39/108 , C12N15/67 , C12N7/00 , A61K39/00 , C07K14/245
CPC分类号： A61K39/0258 , A61K39/00 , A61K2039/522 , A61K2039/5254 , C07K14/245 , C12N7/00 , C12N15/67 , C12N2710/16162 , C12N2710/16662 , C12N2710/16762 , C12N2760/16162 , C12N2760/18462 , C12N2760/18562 , C12N2770/20062 , C12N2770/24162 , C12N2770/32162 , C12N2770/32762 , C12N2770/36262 , Y02A50/466 , Y02A50/472 , Y02A50/476
摘要： Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one or more codons in a coding sequence, thereby reducing the replicative fitness of the pathogen. Methods of using the attenuated pathogens as immunogenic compositions are also disclosed.
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公开(公告)号：US20170296643A1
公开(公告)日：2017-10-19
申请号：US15369405
申请日：2016-12-05
发明人： Laura SERINO , Mariagrazia PIZZA
IPC分类号： A61K39/108 , C07K14/245 , A61K39/00
CPC分类号： A61K39/0258 , A61K2039/54 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/552 , A61K2039/55516 , A61K2039/55544 , A61K2039/70 , C07K14/245 , Y02A50/474
摘要： The invention provides an immunogenic composition comprising a combination of (i) bacterial Ig-like domain protein fragment (orf405B) having the amino acid sequence set forth in SEQ ID NO:2 or a protein having at least 80% similarity thereto, and (ii) putative Lipoprotein (orf3526) having the amino acid sequence set forth in SEQ ID NO:8 or a protein having at least 80% similarity thereto.
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公开(公告)号：US09771399B2
公开(公告)日：2017-09-26
申请号：US14927052
申请日：2015-10-29
IPC分类号： C07K14/22 , A61K39/095 , C07K14/245 , C12N9/10 , A61K39/108 , A61K39/00
CPC分类号： C07K14/245 , A61K39/00 , A61K39/0258 , A61K39/095 , C07K14/22 , C12N9/1051 , Y02A50/474
摘要： Knockout of the meningococcal mltA homolog gives bacteria that spontaneously release vesicles that are rich in immunogenic outer membrane proteins and that can elicit cross-protective antibody responses with higher bactericidal titers than OMVs prepared by normal production processes. Thus the invention provides a bacterium having a knockout mutation of its mltA gene. The invention also provides a bacterium, wherein the bacterium: (i) has a cell wall that includes peptidoglycan; and (ii) does not express a protein having the lytic transglycosylase activity MltA protein. The invention also provides compositions comprising vesicles that, during culture of bacteria of the invention, are released into the culture medium.
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9.发明申请公开(公告)号：US20170258899A1
公开(公告)日：2017-09-14
申请号：US15505379
申请日：2014-08-22
IPC分类号： A61K39/39 , C12N7/00 , A61K39/215 , A61K39/102 , A61K39/002 , A61K39/00 , A61K39/108 , A61K39/112 , A61K39/08 , A61K39/15 , C07K16/02 , C07K16/10 , C07K16/08 , C07K16/12 , C07K16/44 , A61K39/12
CPC分类号： A61K39/39 , A61K39/0002 , A61K39/002 , A61K39/0258 , A61K39/0275 , A61K39/08 , A61K39/102 , A61K39/12 , A61K39/15 , A61K39/215 , A61K2039/505 , A61K2039/5252 , A61K2039/54 , A61K2039/552 , A61K2039/55555 , A61K2039/55566 , A61K2039/55583 , A61K2039/575 , A61K2039/70 , C07K16/02 , C07K16/081 , C07K16/10 , C07K16/1242 , C07K16/44 , C07K2317/11 , C07K2317/23 , C07K2317/76 , C12N7/00 , C12N2710/18034 , C12N2720/12334 , C12N2770/10034 , C12N2770/20034
摘要： The present invention relates to a therapy for treating or preventing several diseases in animals, based on the administration of a highly concentrated avian derived immunoglobulins formulation, obtained from the egg yolk from hens previously hiper-immunized with a vaccine formulation comprising infectious agents or toxins antigens, a light mineral oil and a particulate adjuvant.
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公开(公告)号：US20170181975A1
公开(公告)日：2017-06-29
申请号：US15386695
申请日：2016-12-21
申请人： US Biologic, Inc.
IPC分类号： A61K9/28 , A61K39/02 , A61K39/108 , A61K9/00 , A61K39/09
CPC分类号： A61K9/282 , A61K9/0056 , A61K9/5015 , A61K9/5078 , A61K39/00 , A61K39/0225 , A61K39/0258 , A61K39/09 , A61K2039/523 , A61K2039/542 , A61K2039/552
摘要： The presently disclosed subject matter relates to a composition and method of using the composition for oral delivery of a bioactive agent to a subject. More particularly, the presently disclosed subject matter relates to a composition comprising an effective amount of at least one bioacitve agent layered over a substrate and a method of reducing zoonotic infectious disease by administering the composition to a subject. The presently disclosed subject matter further relates to a method of preparing the composition.
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