公开(公告)号：US11591364B2

公开(公告)日：2023-02-28

申请号：US16768402

申请日：2018-11-30

申请人： GLAXOSMITHKLINE BIOLOGICALS SA

发明人： Ahmad Taimour Baig ,  Felicie Georgette Colette Denet ,  Juan Jose Diaz Garcia ,  Chad Austin Farrenburg ,  Lora Lea Lawrence ,  Kent Raymond Myers ,  Jeri Kay Sandvick ,  Jeb Yeatts Vandenburg

IPC分类号： A61K39/39 ,  C07J63/00 ,  A61K39/12 ,  A61K39/25 ,  C12N7/00 ,  A61K39/00

摘要： Saponin extracts containing at least 93% QS-21 main peak and 0.25-3% 2018 component by UV absorbance at 214 nm, methods for making said extracts, their use as vaccine adjuvants and related aspects.

公开(公告)号：US11744890B2

公开(公告)日：2023-09-05

申请号：US16768416

申请日：2018-11-30

申请人： GLAXOSMITHKLINE BIOLOGICALS SA

发明人： Ahmad Taimour Baig ,  Juan Jose Diaz Garcia ,  Chad Austin Farrenburg ,  Kent Raymond Myers ,  Jeri Kay Sandvick ,  Jeb Yeatts Vandenburg

IPC分类号： A61K36/00 ,  A61K39/39 ,  A61K36/185 ,  A61K39/00

CPC分类号： A61K39/39 ,  A61K36/185 ,  A61K2039/55577 ,  A61K2236/331

摘要： Crude aqueous extracts of Quillaja saponaria Molina containing at least the QS-21 main peak and 2018 component, wherein the ratio of 2018 component/QS-21 main peak is ≤0.075, as measured by UV absorbance at 214 nm, methods for obtaining such extracts and related aspects.