公开(公告)号：US12128094B2

公开(公告)日：2024-10-29

申请号：US17287268

申请日：2019-11-04

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Mario Contorni ,  Mariagrazia Pizza ,  Anja Seubert

IPC: A61P31/04 ,  A61K39/00

CPC classification number: A61K39/0018 ,  A61P31/04 ,  A61K2039/55505

Abstract: The invention provides an immunogenic composition comprising OMVs and (a) acellular pertussis antigen, (b) a tetanus toxoid and (c) a diphtheria toxoid, wherein the OMVs are derived from Bordetella pertussis. The invention also provides compositions for use in a method for raising an immune response in a patient, comprising the step of administering to the patient a composition of the invention.