公开(公告)号：US20170143816A1

公开(公告)日：2017-05-25

申请号：US15127537

申请日：2015-03-24

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Fabio BAGNOLI ,  Luigi FIASCHI ,  Maria SCARSELLI

IPC: A61K39/085 ,  C07K14/31

CPC classification number: A61K39/085 ,  A61K35/74 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/55577 ,  A61K2039/645 ,  A61K2039/70 ,  C07K14/31 ,  C07K2319/00 ,  C07K2319/40

Abstract: Mutant protein A of Staphylococcus aureus (SpA) with decreased affinity for the Fcγ portion of human IgG is provided.

公开(公告)号：US20160158335A1

公开(公告)日：2016-06-09

申请号：US14961772

申请日：2015-12-07

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Fabio BAGNOLI ,  Massimiliano BIAGINI ,  Luigi FIASCHI ,  Guido GRANDI ,  Ravi Pratap Narayan MISHRA ,  Nathalie NORAIS ,  Maria SCARSELLI

IPC: A61K39/085 ,  C07K14/31

CPC classification number: A61K39/085 ,  A61K39/00 ,  C07K14/31 ,  C07K2319/00

Abstract: An effective Staphylococcus aureus vaccine may require several antigenic components, and so various combinations of S. aureus antigens are identified for use in immunisation. These polypeptides may optionally be used in combination with S. aureus saccharides.

Abstract translation: 有效的金黄色葡萄球菌疫苗可能需要几种抗原成分，因此鉴定出金黄色葡萄球菌抗原的各种组合用于免疫。 这些多肽可以任选地与金黄色葡萄球菌组合使用。

公开(公告)号：US20210023192A1

公开(公告)日：2021-01-28

申请号：US16968895

申请日：2019-02-12

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Fabio BAGNOLI ,  Carine GORAJ

IPC: A61K39/085 ,  A61P31/04

Abstract: The invention provides an immunogenic composition comprising staphylococcal antigens, containing protein antigens and conjugates of capsular polysaccharides, n particular Hla, ClfA, SpA and conjugates of capsular polysaccharides. Adjuvanted formulations are also provided. The invention may find use in the prevention and treatment of staphylococcal infections, in particular S. aureus infection and disease.

公开(公告)号：US20170340720A1

公开(公告)日：2017-11-30

申请号：US15589834

申请日：2017-05-08

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Fabio BAGNOLI ,  Massimiliano BIAGINI ,  Luigi FIASCHI ,  Guido GRANDI ,  Ravi Pratap Narayan MISHRA ,  Nathalie NORAIS ,  Maria SCARSELLI

IPC: A61K39/085 ,  C07K14/31 ,  A61K39/00

CPC classification number: A61K39/085 ,  A61K39/00 ,  C07K14/31 ,  C07K2319/00

Abstract: An effective Staphylococcus aureus vaccine may require several antigenic components, and so various combinations of S. aureus antigens are identified for use in immunisation. These polypeptides may optionally be used in combination with S. aureus saccharides.

公开(公告)号：US20180064800A9

公开(公告)日：2018-03-08

申请号：US15127537

申请日：2015-03-24

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Fabio BAGNOLI ,  Luigi FIASCHI ,  Maria SCARSELLI

IPC: A61K39/085 ,  C07K14/31

CPC classification number: A61K39/085 ,  A61K35/74 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/55577 ,  A61K2039/645 ,  A61K2039/70 ,  C07K14/31 ,  C07K2319/00 ,  C07K2319/40

Abstract: Mutant protein A of Staphylococcus aureus (SpA) with decreased affinity for the Fcγ portion of human IgG is provided.

公开(公告)号：US20230052495A1

公开(公告)日：2023-02-16

申请号：US17869055

申请日：2022-07-20

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Fabio BAGNOLI ,  Carine GORAJ

IPC: A61K39/085 ,  A61P31/04

Abstract: The invention provides an immunogenic composition comprising staphylococcal antigens, containing protein antigens and conjugates of capsular polysaccharides. Adjuvanted formulations are also provided. The invention may find use in the prevention and treatment of staphylococcal infections.

公开(公告)号：US20230045642A1

公开(公告)日：2023-02-09

申请号：US17783725

申请日：2020-12-15

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Fabio BAGNOLI ,  Andreas HAAG ,  Lassi LILJEROOS

IPC: A61K39/085 ,  C07K14/31 ,  A61P31/04

Abstract: The invention provides improved staphylococcal antigens. Immunogenic compositions are also provided. The invention may find use in the prevention and treatment of staphylococcal infections.