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1.
公开(公告)号:US09938243B2
公开(公告)日:2018-04-10
申请号:US15698020
申请日:2017-09-07
发明人: Peter Kumpalume , Oliver Schon , Christine Patricia Donahue , Ghotas Evindar , David I. Israel , David Paolella , Letian Kuai , Ninad V. Prabhu
IPC分类号: C07D235/18 , A61K31/454 , C07D411/14 , A61K31/4545 , A61K31/4184 , C07D401/06 , C07D235/24 , C07D401/10 , C07D417/14
CPC分类号: C07D235/18 , A61K31/4184 , A61K31/454 , A61K31/4545 , C07D235/24 , C07D401/06 , C07D401/10 , C07D411/14 , C07D417/14
摘要: Compounds useful for affinity chromatography as presented, more particularly for use in affinity chromatography to purify serum albumin, especially human serum albumin (HSA) and fusion proteins thereof. Methods for extending the half-life of therapeutic agents are also presented, particularly therapeutic peptide agents and small molecules, such as by conjugation of compounds described herein to the therapeutic peptide or small molecule, which, upon administration, binds to HSA, thereby providing a prolonged release of the therapeutic agent.
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2.
公开(公告)号:US09809558B2
公开(公告)日:2017-11-07
申请号:US15026725
申请日:2014-10-01
发明人: Peter Kumpalume , Oliver Schon , Christine Patricia Donahue , Ghotas Evindar , David I. Israel , David Paolella , Letian Kuai , Ninad V. Prabhu
IPC分类号: C07D235/18 , A61K31/4184 , C07D401/06 , C07D401/10 , C07D235/24 , C07D417/14 , A61K31/454 , A61K31/4545 , C07D411/14
CPC分类号: C07D235/18 , A61K31/4184 , A61K31/454 , A61K31/4545 , C07D235/24 , C07D401/06 , C07D401/10 , C07D411/14 , C07D417/14
摘要: Compounds useful for affinity chromatography as presented, more particularly for use in affinity chromatography to purify serum albumin, especially human serum albumin (HSA) and fusion proteins thereof. Methods for extending the half-life of therapeutic agents are also presented, particularly therapeutic peptide agents and small molecules, such as by conjugation of compounds described herein to the therapeutic peptide or small molecule, which upon administration, binds to HSA, thereby providing a prolonged release of the therapeutic agent.
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