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1.
公开(公告)号:US20190209580A1
公开(公告)日:2019-07-11
申请号:US16240438
申请日:2019-01-04
申请人: Cybrexa, Inc.
IPC分类号: A61K31/55 , A61K31/4184 , A61K31/5375 , A61K31/454 , A61K31/5025 , A61K47/64 , A61K47/54 , A61P25/28 , A61P35/00
CPC分类号: A61K31/55 , A61K31/4184 , A61K31/454 , A61K31/5025 , A61K31/5375 , A61K38/16 , A61K45/06 , A61K47/549 , A61K47/64 , A61K47/6425 , A61P9/00 , A61P25/28 , A61P35/00 , C07D231/56 , C07D235/18 , C07D295/092 , C07D401/06 , C07D401/10 , C07D403/04 , C07D403/06 , C07D487/16
摘要: Compounds for treatment of diseases having acidic or hypoxic diseased tissues and pharmaceutical compositions comprising the compounds, as well as methods for making and using the compounds and compositions.
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公开(公告)号:US10081629B2
公开(公告)日:2018-09-25
申请号:US15303704
申请日:2015-03-31
发明人: Xin Li , Wei He , Xianbo Liu , Bin Wang , Qiyue Hu , Fangfang Jin , Qing Dong , Piaoyang Sun
IPC分类号: C07D307/78 , C07D307/87 , C07D471/04 , C07C233/47 , C07C233/63 , C07D209/10 , C07D209/44 , C07D231/56 , C07D235/18 , C07D263/57 , C07D401/04 , C07D401/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12
CPC分类号: C07D471/04 , C07C233/47 , C07C233/63 , C07C2601/02 , C07D209/10 , C07D209/44 , C07D231/56 , C07D235/18 , C07D263/57 , C07D401/04 , C07D401/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12
摘要: Amide derivatives and pharmaceutically acceptable salts thereof, preparation method thereof and medicinal application thereof are provided. Specifically, amide derivatives represented by general formula (I) are provided. The amide derivatives represented by general formula (I) can be used as a therapeutic agent, particularly as an inhibitor for microsomal prostaglandin E synthase-1 (mPGES-1), and also to treat and/or prevent diseases or illnesses such as inflammation and/or pain etc. The definition of each substituent group in general formula (I) is the same as the definition in the description.
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公开(公告)号:US10026901B2
公开(公告)日:2018-07-17
申请号:US14404609
申请日:2013-06-05
申请人: GUANGDONG AGLAIA OPTOELECTRONIC MATERIALS CO., LTD , BEIJING AGLAIA TECHNOLOGY DEVELOPMENT CO., LTD
发明人: Jinhai Huang , Lei Dai , Jinxin Chen , Lifei Cai
IPC分类号: H01L51/54 , C09K11/06 , H01L51/00 , C07F9/53 , C07D333/76 , C07F15/00 , C07D235/18 , C07C211/54 , C07D239/26 , C07D249/08 , C07D251/24 , C07D271/107 , C07D209/86 , C07C13/66 , C07D213/06 , C07D213/16 , C07D307/91 , C07F7/08 , C07D235/20 , C07C13/72 , C09B57/00 , C09B69/00 , C07D235/08 , H01L51/50
CPC分类号: H01L51/0054 , C07C13/66 , C07C13/72 , C07C211/54 , C07C2603/18 , C07C2603/40 , C07C2603/94 , C07D209/86 , C07D213/06 , C07D213/16 , C07D235/08 , C07D235/18 , C07D235/20 , C07D239/26 , C07D249/08 , C07D251/24 , C07D271/107 , C07D307/91 , C07D333/76 , C07F7/0805 , C07F9/5325 , C07F9/5329 , C07F15/0033 , C09B57/00 , C09B57/008 , C09B69/008 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1014 , C09K2211/1029 , C09K2211/1044 , C09K2211/1048 , C09K2211/1051 , C09K2211/1059 , H01L51/0058 , H01L51/0067 , H01L51/0072 , H01L51/0094 , H01L51/5012 , H01L51/5016 , H01L51/5056 , H01L51/5072 , H01L51/5092
摘要: An organic light-emitting material having the structure of formula (I) or (II) as described below and an organic light-emitting device (OLED) are disclosed. The OLED adopts the compound containing fluoranthene group as the electron transport material possessing good electron transport and injection ability. The material also enhances the luminous efficiency and lifetime of the device because of its excellent thermal stability and film-forming properties. At the same time, the high triplet energy and excellent electron transport capacity of the material containing fluoranthene group make it suitable to be used as the host for phosphorescent devices, increasing the number of electrons in the light-emitting layer and the efficiency of the device.
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公开(公告)号:US09997726B2
公开(公告)日:2018-06-12
申请号:US14802051
申请日:2015-07-17
发明人: Chun Lin , Alexey Dyatkin , Zeinab Elshenawy , Walter Yeager
IPC分类号: H01L51/50 , H01L51/00 , C07D209/86 , C07D235/18 , C07D235/20 , C07D333/76 , C07D405/14 , C07D409/10 , C07D409/14 , C07D413/10 , C07D471/04 , C07D487/04 , C07F5/02 , C07F7/08 , C09K11/02 , C09K11/06
CPC分类号: H01L51/0074 , C07D209/86 , C07D235/18 , C07D235/20 , C07D333/76 , C07D405/14 , C07D409/10 , C07D409/14 , C07D413/10 , C07D471/04 , C07D487/04 , C07F5/027 , C07F7/0814 , C09K11/025 , C09K11/06 , C09K2211/1007 , C09K2211/1029 , C09K2211/1044 , C09K2211/185 , H01L51/0067 , H01L51/0071 , H01L51/0072 , H01L51/0085 , H01L51/5016
摘要: An organic light emitting device that includes an anode, a cathode, and an emissive layer that includes an organic compound selected from and at least one emissive dopant. The emissive dopant can be one of a variety of organometallic iridium complexes.
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公开(公告)号:US20180145272A1
公开(公告)日:2018-05-24
申请号:US15568116
申请日:2016-09-09
申请人: LG CHEM, LTD.
发明人: Yongbum CHA , Jin Joo KIM , Seong So KIM , Jemin RYU
IPC分类号: H01L51/50 , C09K11/06 , C07C13/567 , C07C13/72
CPC分类号: H01L51/508 , C07C13/567 , C07C13/72 , C07C25/22 , C07C211/54 , C07C211/61 , C07C255/58 , C07C2603/18 , C07C2603/94 , C07D209/86 , C07D213/16 , C07D235/18 , C07D239/26 , C07D239/74 , C07D251/24 , C07D307/91 , C07D333/76 , C07F5/025 , C07F7/0812 , C07F9/5325 , C09K11/06 , H01L51/50 , H01L51/5064
摘要: The present specification relates to a novel compound and an organic light emitting device including the same.
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6.
公开(公告)号:US09938243B2
公开(公告)日:2018-04-10
申请号:US15698020
申请日:2017-09-07
发明人: Peter Kumpalume , Oliver Schon , Christine Patricia Donahue , Ghotas Evindar , David I. Israel , David Paolella , Letian Kuai , Ninad V. Prabhu
IPC分类号: C07D235/18 , A61K31/454 , C07D411/14 , A61K31/4545 , A61K31/4184 , C07D401/06 , C07D235/24 , C07D401/10 , C07D417/14
CPC分类号: C07D235/18 , A61K31/4184 , A61K31/454 , A61K31/4545 , C07D235/24 , C07D401/06 , C07D401/10 , C07D411/14 , C07D417/14
摘要: Compounds useful for affinity chromatography as presented, more particularly for use in affinity chromatography to purify serum albumin, especially human serum albumin (HSA) and fusion proteins thereof. Methods for extending the half-life of therapeutic agents are also presented, particularly therapeutic peptide agents and small molecules, such as by conjugation of compounds described herein to the therapeutic peptide or small molecule, which, upon administration, binds to HSA, thereby providing a prolonged release of the therapeutic agent.
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公开(公告)号:US09926290B2
公开(公告)日:2018-03-27
申请号:US14967568
申请日:2015-12-14
IPC分类号: C07D401/04 , C07D401/14 , C07D405/04 , C07D235/18
CPC分类号: C07D401/04 , C07D235/18 , C07D401/14 , C07D405/04
摘要: This invention describes the development of targeted small molecule inhibitors of the inv(16) fusion, the causative agent in ˜12% of acute myeloid leukemia (AML). The inv(16) fusion results in expression of the CBFβ-SMMHC fusion protein in the blood cells of afflicted patients. The present invention provides compounds which inhibit the function of both CBFβ and the CBFβ-SMMHC fusion. These compounds block the growth of an inv(16) leukemia cell line as well as increase its apoptosis, while showing minimal effects against non inv(16) cell lines. As a mechanism to develop inhibitors with selectivity for the CBFβ-SMMHC fusion protein, the present invention further provides dimeric derivatives of these compounds which show both increased potency as well as selectivity for CBFβ-SMMHC. These compounds show potent inhibition of an inv(16) leukemia cell line with minimal effects on non inv(16) cell lines. Analysis of the pharmacokinetics of the developed compounds has made it possible to improve the lifetime of the compound in the plasma of mice to a level commensurate with long-term treatment.
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公开(公告)号:US09923143B2
公开(公告)日:2018-03-20
申请号:US14778797
申请日:2014-04-17
申请人: LG CHEM, LTD.
发明人: Jaesoon Bae , Jaechol Lee , Jiyoung Lee , Hangken Lee , Songrim Jang , Jeong Min Choi , Jinseck Kim , Keun Cho , Doo Whan Choi
IPC分类号: H01L51/00 , C01B32/152 , C07C69/616 , C07C69/75 , C07C69/753 , C07C219/32 , C07C255/55 , C07C327/22 , C07D235/18 , C07D277/36 , C07D333/16 , C07D417/14 , H01L51/42
CPC分类号: H01L51/0047 , C01B32/152 , C07C69/616 , C07C69/75 , C07C69/753 , C07C219/32 , C07C255/55 , C07C327/22 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D235/18 , C07D277/36 , C07D333/16 , C07D417/14 , H01L51/0037 , H01L51/4253 , Y02E10/549 , Y02P70/521
摘要: The present specification relates to a fullerene derivative, an organic solar cell including the same, and a fabricating method thereof.
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公开(公告)号:US09818957B2
公开(公告)日:2017-11-14
申请号:US14784333
申请日:2015-02-02
发明人: Yosuke Nishide , Jun Kamatani , Hiroki Ohrui , Yojiro Matsuda , Masanori Muratsubaki , Satoru Shiobara , Tetsuo Takahashi , Haruna Iida
IPC分类号: H01L29/08 , H01L51/50 , H01L51/00 , C07D221/04 , C07D409/14 , C07D249/08 , C07D251/24 , C07D471/04 , C07D213/22 , C07D213/26 , C07D213/30 , C09K11/06 , C07D405/14 , C07D413/14 , C07D311/86 , C07D333/76 , C07D335/16 , C07D235/18 , C07D403/14 , C07D471/06 , C07D493/06 , C07D271/107 , C07D209/86 , C07D213/38 , C07D213/61 , C07D213/64 , H05B33/08 , H01L27/32 , H01L29/24 , H01L29/786
CPC分类号: H01L51/0067 , C07D209/86 , C07D213/22 , C07D213/26 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/64 , C07D221/04 , C07D235/18 , C07D249/08 , C07D251/24 , C07D271/107 , C07D311/86 , C07D333/76 , C07D335/16 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/06 , C07D493/06 , C09K11/06 , C09K2211/1029 , H01L27/3244 , H01L29/24 , H01L29/7869 , H01L51/0006 , H01L51/005 , H01L51/0052 , H01L51/0053 , H01L51/0055 , H01L51/0056 , H01L51/0058 , H01L51/0072 , H01L51/5012 , H01L51/5076 , H01L51/5092 , H01L2251/308 , H01L2251/5361 , H01L2251/556 , H05B33/0896
摘要: Provided is an organic light emitting element having stable performance in the air. The organic light emitting element includes: an anode; a cathode; and a first organic compound layer placed between the anode and the cathode, in which: the organic light emitting element further includes a first organic compound layer placed between the cathode and the emission layer, and a second organic compound layer placed between the emission layer and the first organic compound layer, and brought into contact with the first organic compound layer; the first organic compound layer contains a first organic compound; the second organic compound layer contains a second organic compound; and the first organic compound includes an organic compound represented by the following general formula [1], and the second organic compound includes an organic compound different from the first organic compound
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10.
公开(公告)号:US09809558B2
公开(公告)日:2017-11-07
申请号:US15026725
申请日:2014-10-01
发明人: Peter Kumpalume , Oliver Schon , Christine Patricia Donahue , Ghotas Evindar , David I. Israel , David Paolella , Letian Kuai , Ninad V. Prabhu
IPC分类号: C07D235/18 , A61K31/4184 , C07D401/06 , C07D401/10 , C07D235/24 , C07D417/14 , A61K31/454 , A61K31/4545 , C07D411/14
CPC分类号: C07D235/18 , A61K31/4184 , A61K31/454 , A61K31/4545 , C07D235/24 , C07D401/06 , C07D401/10 , C07D411/14 , C07D417/14
摘要: Compounds useful for affinity chromatography as presented, more particularly for use in affinity chromatography to purify serum albumin, especially human serum albumin (HSA) and fusion proteins thereof. Methods for extending the half-life of therapeutic agents are also presented, particularly therapeutic peptide agents and small molecules, such as by conjugation of compounds described herein to the therapeutic peptide or small molecule, which upon administration, binds to HSA, thereby providing a prolonged release of the therapeutic agent.
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