公开(公告)号：US10479792B2

公开(公告)日：2019-11-19

申请号：US15750896

申请日：2016-08-03

Applicant: GlaxoSmithKline Intellectual Property Development Limited ,  University of Dundee

Inventor： Stephen Brand ,  Peter George Dodd ,  Eun Jung Ko ,  Maria Marco Martin ,  Timothy James Miles ,  Lars Henrik Sandberg ,  Michael George Thomas ,  Stephen Thompson

IPC: C07D487/04 ,  A61K31/53 ,  A61K31/52 ,  A61P33/02 ,  A61P33/14 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/553

Abstract: A compound of Formula (I), or a salt thereof, compositions comprising the compound, processes for its preparation and its use in therapy, for example in the treatment of parasitic diseases such as Chagas disease, Human African Trypanosomiasis (HAT), Animal African trypanosomiasis (AAT) and leishmaniasis, particularly visceral leishmaniasis (VL).

公开(公告)号：US10683307B2

公开(公告)日：2020-06-16

申请号：US16415319

申请日：2019-05-17

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Haifeng Cui ,  Alan Hennessy ,  Qi Jin ,  Timothy James Miles ,  Stephen Frederick Moss ,  Neil David Pearson

IPC: C07D498/04 ,  C07D513/04 ,  C07D519/00 ,  A61P31/04

Abstract: The present invention relates to novel compounds or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions and treatment methods or uses as antibacterials for bacterial infections.

公开(公告)号：US10364254B2

公开(公告)日：2019-07-30

申请号：US15752639

申请日：2016-08-15

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Haifeng Cui ,  Alan Hennessy ,  Qi Jin ,  Timothy James Miles ,  Stephen Frederick Moss ,  Neil David Pearson

IPC: A61P31/04 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present invention relates to novel compounds or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions and treatment methods or uses as antibacterials for bacterial infections.

公开(公告)号：US20190270755A1

公开(公告)日：2019-09-05

申请号：US16415319

申请日：2019-05-17

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Haifeng CUI ,  Alan Hennessy ,  Qi Jin ,  Timothy James Miles ,  Stephen Frederick Moss ,  Neil David Pearson

IPC: C07D498/04 ,  A61P31/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present invention relates to novel compounds or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions and treatment methods or uses as antibacterials for bacterial infections.

公开(公告)号：US10065965B2

公开(公告)日：2018-09-04

申请号：US15575032

申请日：2016-05-26

Applicant: GlaxoSmithKline Intellectual Property Development Limited ,  The University of Dundee

Inventor： Stephen Brand ,  Elisabet Viayna Gaza ,  Ian Gilbert ,  Eun Jung Ko ,  Maria Marco Martin ,  Timothy James Miles ,  Lars Henrik Sandberg ,  Michael George Thomas

IPC: C07D487/04 ,  A61K31/53 ,  A61P33/02 ,  A61K45/06 ,  A61K31/5377

Abstract: A compound of Formula (I), or a salt thereof, compositions comprising the compound, processes for its preparation and its use in therapy, for example in the treatment of parasitic diseases such as Chagas disease, Human African Trypanosomiasis (HAT) and leishmaniasis, particularly visceral leishmaniasis (VL).

公开(公告)号：US10253028B2

公开(公告)日：2019-04-09

申请号：US15545193

申请日：2016-01-21

Applicant: GlaxoSmithKline Intellectual Property Development Limited ,  University of Dundee

Inventor： Timothy James Miles ,  Michael George Thomas

IPC: A61K31/5377 ,  C07D487/04

Abstract: The compound 3,3,3-trifluoro-N-((1,4-trans)-4-((3-((S)-2-methylmorpholino)-IH-pyrazolo[3,4-d]pyrimidin-6-yl)amino)cyclohexyl)propane-1-sulfonamide having the Formula (I) or a salt thereof, its opposite enantiomer, compositions comprising the compound and its use in the treatment or prevention of leishmaniasis, particularly visceral leishmaniasis.