公开(公告)号：US10781184B2

公开(公告)日：2020-09-22

申请号：US16060641

申请日：2016-12-08

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Qi Jin ,  Denise Teotico Pohlhaus ,  Jared T. Spletstoser

IPC: C07D239/88 ,  C07D217/24 ,  C07D401/04 ,  C07D401/10 ,  C07D403/10 ,  C07D405/04 ,  C07D409/04 ,  C07D417/04 ,  C07D253/08 ,  C07D209/46 ,  A61P31/04 ,  C07D413/10

Abstract: The present invention relates to LpxC antibacterial compounds of Formula (IA): corresponding pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, compound preparation, treatment methods and uses for bacterial infections, especially those caused by gram-negative bacteria.

公开(公告)号：US10683307B2

公开(公告)日：2020-06-16

申请号：US16415319

申请日：2019-05-17

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Haifeng Cui ,  Alan Hennessy ,  Qi Jin ,  Timothy James Miles ,  Stephen Frederick Moss ,  Neil David Pearson

IPC: C07D498/04 ,  C07D513/04 ,  C07D519/00 ,  A61P31/04

Abstract: The present invention relates to novel compounds or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions and treatment methods or uses as antibacterials for bacterial infections.

公开(公告)号：US10364254B2

公开(公告)日：2019-07-30

申请号：US15752639

申请日：2016-08-15

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Haifeng Cui ,  Alan Hennessy ,  Qi Jin ,  Timothy James Miles ,  Stephen Frederick Moss ,  Neil David Pearson

IPC: A61P31/04 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present invention relates to novel compounds or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions and treatment methods or uses as antibacterials for bacterial infections.

公开(公告)号：US20190270755A1

公开(公告)日：2019-09-05

申请号：US16415319

申请日：2019-05-17

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Haifeng CUI ,  Alan Hennessy ,  Qi Jin ,  Timothy James Miles ,  Stephen Frederick Moss ,  Neil David Pearson

IPC: C07D498/04 ,  A61P31/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present invention relates to novel compounds or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions and treatment methods or uses as antibacterials for bacterial infections.