公开(公告)号：US20160319027A1

公开(公告)日：2016-11-03

申请号：US15092265

申请日：2016-04-06

申请人： GLENMARK PHARMACEUTICALS S.A.

发明人： Stanislas BLEIN ,  Romain OLLIER ,  Darko SKEGRO ,  Adrian WALMSLEY ,  Harald MOTTL

IPC分类号： C07K16/28 ,  A61K45/06 ,  A61K9/00 ,  A61K39/395

CPC分类号： C07K16/2863 ,  A61K9/0019 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/545 ,  C07K16/22 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention relates generally to antibodies directed against TrkA receptor and their uses, including humanized anti-TrkA antibodies and methods of treatment with anti-TrkA antibodies. In one aspect, the present invention relates to humanized anti-TrkA antibodies with enhanced inhibitory properties for use in methods of treating neuroma and/or bone associated pain.