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    Modified release dosage forms of skeletal muscle relaxants
    1.
    发明授权
    Modified release dosage forms of skeletal muscle relaxants 有权
    骨骼肌松弛剂的改性释放剂型

    公开(公告)号：US07829121B2

    公开(公告)日：2010-11-09

    申请号：US12236719

    申请日：2008-09-24

    Applicant: Gopi Venkatesh ,  James M. Clevenger

    Inventor： Gopi Venkatesh ,  James M. Clevenger

    IPC: A61K9/14

    CPC classification number: A61K31/135 ,  A61K9/0053 ,  A61K9/1652 ,  A61K9/2054 ,  A61K9/4808 ,  A61K9/4866 ,  A61K9/5078 ,  A61K31/137 ,  A61K31/5513 ,  Y10T29/49826

    Abstract: A unit dosage form, such as a capsule or the like, for delivering a skeletal muscle relaxant, such as cyclobenzaprine hydrochloride, into the body in an extended or sustained release fashion comprising one or more populations of drug-containing particles (beads, pellets, granules, etc.) is disclosed. At least one bead population exhibits a pre-designed sustained release profile. Such a drug delivery system is designed for once-daily oral administration to maintain an adequate plasma concentration—time profile, thereby providing relief of muscle spasm associated with painful musculoskeletal conditions over a 24 hour period.

    Abstract translation: 用于以延长或持续释放的方式将骨骼肌松弛剂（例如盐酸环苯扎林）输送到体内的单位剂型，包括一种或多种含药颗粒群（珠粒，丸粒， 颗粒等）。 至少一个珠粒表现出预先设计的持续释放特征。 这种药物递送系统设计为每日一次口服给药以维持足够的血浆浓度 - 时间特征，从而在24小时内缓解与疼痛的肌肉骨骼病症相关的肌肉痉挛。

    Modified Release Dosage Forms of Skeletal Muscle Relaxants
    2.
    发明申请
    Modified Release Dosage Forms of Skeletal Muscle Relaxants 有权
    骨骼肌松弛剂的改性释放剂量形式

    公开(公告)号：US20090017126A1

    公开(公告)日：2009-01-15

    申请号：US12236719

    申请日：2008-09-24

    Applicant: Gopi Venkatesh ,  James M. Clevenger

    Inventor： Gopi Venkatesh ,  James M. Clevenger

    IPC: A61K9/50 ,  A61P21/02

    CPC classification number: A61K31/135 ,  A61K9/0053 ,  A61K9/1652 ,  A61K9/2054 ,  A61K9/4808 ,  A61K9/4866 ,  A61K9/5078 ,  A61K31/137 ,  A61K31/5513 ,  Y10T29/49826

    Abstract: A unit dosage form, such as a capsule or the like, for delivering a skeletal muscle relaxant, such as cyclobenzaprine hydrochloride, into the body in an extended or sustained release fashion comprising one or more populations of drug-containing particles (beads, pellets, granules, etc.) is disclosed. At least one bead population exhibits a pre-designed sustained release profile. Such a drug delivery system is designed for once-daily oral administration to maintain an adequate plasma concentration—time profile, thereby providing relief of muscle spasm associated with painful musculoskeletal conditions over a 24 hour period.

    Abstract translation: 用于以延长或持续释放的方式将骨骼肌松弛剂（例如盐酸环苯扎林）输送到体内的单位剂型，包括一种或多种含药颗粒群（珠粒，丸粒， 颗粒等）。 至少一个珠粒表现出预先设计的持续释放特征。 这种药物递送系统设计为每日一次口服给药以维持足够的血浆浓度 - 时间特征，从而在24小时内缓解与疼痛的肌肉骨骼病症相关的肌肉痉挛。

    MODIFIED RELEASE DOSAGE FORMS OF SKELETAL MUSCLE RELAXANTS
    4.
    发明申请
    MODIFIED RELEASE DOSAGE FORMS OF SKELETAL MUSCLE RELAXANTS 有权
    修饰释放剂量的骨骼肌松弛剂

    公开(公告)号：US20080124399A1

    公开(公告)日：2008-05-29

    申请号：US12026887

    申请日：2008-02-06

    Applicant: GOPI VENKATESH ,  James M. Clevenger

    Inventor： GOPI VENKATESH ,  James M. Clevenger

    IPC: A61K9/14 ,  A61K31/135 ,  A61P21/02

    CPC classification number: A61K31/135 ,  A61K9/0053 ,  A61K9/1652 ,  A61K9/2054 ,  A61K9/4808 ,  A61K9/4866 ,  A61K9/5078 ,  A61K31/137 ,  A61K31/5513 ,  Y10T29/49826

    Abstract: A unit dosage form, such as a capsule or the like, for delivering a skeletal muscle relaxant, such as cyclobenzaprine hydrochloride, into the body in an extended or sustained release fashion comprising one or more populations of drug-containing particles (beads, pellets, granules, etc.) is disclosed. At least one bead population exhibits a pre-designed sustained release profile. Such a drug delivery system is designed for once-daily oral administration to maintain an adequate plasma concentration-time profile, thereby providing relief of muscle spasm associated with painful musculoskeletal conditions over a 24 hour period.

    Abstract translation: 用于以延长或持续释放的方式将骨骼肌松弛剂（例如盐酸环苯扎林）输送到体内的单位剂型，包括一种或多种含药颗粒群（珠粒，丸粒， 颗粒等）。 至少一个珠粒表现出预先设计的持续释放特征。 这种药物递送系统设计为每日一次口服给药以维持足够的血浆浓度 - 时间特征，从而在24小时内缓解与疼痛的肌肉骨骼病症相关的肌肉痉挛。

    Modified release dosage forms of skeletal muscle relaxants
    6.
    发明授权
    Modified release dosage forms of skeletal muscle relaxants 有权
    骨骼肌松弛剂的改性释放剂型

    公开(公告)号：US07387793B2

    公开(公告)日：2008-06-17

    申请号：US10713929

    申请日：2003-11-14

    Applicant: Gopi Venkatesh ,  James M. Clevenger

    Inventor： Gopi Venkatesh ,  James M. Clevenger

    IPC: A61K9/14

    CPC classification number: A61K31/135 ,  A61K9/0053 ,  A61K9/1652 ,  A61K9/2054 ,  A61K9/4808 ,  A61K9/4866 ,  A61K9/5078 ,  A61K31/137 ,  A61K31/5513 ,  Y10T29/49826

    Abstract: A unit dosage form, such as a capsule or the like, for delivering a skeletal muscle relaxant, such as cyclobenzaprine hydrochloride, into the body in an extended or sustained release fashion comprising one or more populations of drug-containing particles (beads, pellets, granules, etc.) is disclosed. At least one bead population exhibits a pre-designed sustained release profile. Such a drug delivery system is designed for once-daily oral administration to maintain an adequate plasma concentration—time profile, thereby providing relief of muscle spasm associated with painful musculoskeletal conditions over a 24 hour period.

    Abstract translation: 用于以延长或持续释放的方式将骨骼肌松弛剂（例如盐酸环苯扎林）输送到体内的单位剂型，包括一种或多种含药颗粒群（珠粒，丸粒， 颗粒等）。 至少一个珠粒表现出预先设计的持续释放特征。 这种药物递送系统设计为每日一次口服给药以维持足够的血浆浓度 - 时间特征，从而在24小时内缓解与疼痛的肌肉骨骼病症相关的肌肉痉挛。

    Modified release dosage forms of skeletal muscle relaxants
    7.
    发明授权
    Modified release dosage forms of skeletal muscle relaxants 有权
    骨骼肌松弛剂的改性释放剂型

    公开(公告)号：US08877245B2

    公开(公告)日：2014-11-04

    申请号：US13570670

    申请日：2012-08-09

    Applicant: Gopi Venkatesh ,  James M. Clevenger

    Inventor： Gopi Venkatesh ,  James M. Clevenger

    IPC: A61K9/14 ,  A61K31/5513 ,  A61K9/50 ,  A61K31/137

    CPC classification number: A61K31/135 ,  A61K9/0053 ,  A61K9/1652 ,  A61K9/2054 ,  A61K9/4808 ,  A61K9/4866 ,  A61K9/5078 ,  A61K31/137 ,  A61K31/5513 ,  Y10T29/49826

    Abstract: A unit dosage form, such as a capsule or the like, for delivering a skeletal muscle relaxant, such as cyclobenzaprine hydrochloride, into the body in an extended or sustained release fashion comprising one or more populations of drug-containing particles (beads, pellets, granules, etc.) is disclosed. At least one bead population exhibits a pre-designed sustained release profile. Such a drug delivery system is designed for once—daily oral administration to maintain an adequate plasma concentration—time profile, thereby providing relief of muscle spasm associated with painful musculoskeletal conditions over a 24 hour period.

    Abstract translation: 用于以延长或持续释放的方式将骨骼肌松弛剂（例如盐酸环苯扎林）输送到体内的单位剂型，包括一种或多种含药颗粒群（珠粒，丸粒， 颗粒等）。 至少一个珠粒表现出预先设计的持续释放特征。 这种药物递送系统设计为每日一次口服给药以维持足够的血浆浓度 - 时间特征，从而在24小时内缓解与疼痛的肌肉骨骼病症相关的肌肉痉挛。

    Modified Release Dosage Forms of Skeletal Muscle Relaxants
    8.
    发明申请
    Modified Release Dosage Forms of Skeletal Muscle Relaxants 审中-公开
    骨骼肌松弛剂的改性释放剂量形式

    公开(公告)号：US20110217384A1

    公开(公告)日：2011-09-08

    申请号：US12872354

    申请日：2010-08-31

    Applicant: Gopi Venkatesh ,  James M. Clevenger

    Inventor： Gopi Venkatesh ,  James M. Clevenger

    IPC: A61K9/14 ,  A61K9/50 ,  A61K31/135 ,  A61P21/02

    CPC classification number: A61K31/135 ,  A61K9/0053 ,  A61K9/1652 ,  A61K9/2054 ,  A61K9/4808 ,  A61K9/4866 ,  A61K9/5078 ,  A61K31/137 ,  A61K31/5513 ,  Y10T29/49826

    Abstract: A unit dosage form, such as a capsule or the like, for delivering a skeletal muscle relaxant, such as cyclobenzaprine hydrochloride, into the body in an extended or sustained release fashion comprising one or more populations of drug-containing particles (beads, pellets, granules, etc.) is disclosed. At least one bead population exhibits a pre-designed sustained release profile. Such a drug delivery system is designed for once-daily oral administration to maintain an adequate plasma concentration—time profile, thereby providing relief of muscle spasm associated with painful musculoskeletal conditions over a 24 hour period.

    Abstract translation: 用于以延长或持续释放的方式将骨骼肌松弛剂（例如盐酸环苯扎林）输送到体内的单位剂型，包括一种或多种含药颗粒群（珠粒，丸粒， 颗粒等）。 至少一个珠粒表现出预先设计的持续释放特征。 这种药物递送系统设计为每日一次口服给药以维持足够的血浆浓度 - 时间特征，从而在24小时内缓解与疼痛的肌肉骨骼病症相关的肌肉痉挛。

    Modified release dosage forms of skeletal muscle relaxants
    9.
    发明授权
    Modified release dosage forms of skeletal muscle relaxants 有权
    骨骼肌松弛剂的改性释放剂型

    公开(公告)号：US07544372B2

    公开(公告)日：2009-06-09

    申请号：US12026887

    申请日：2008-02-06

    Applicant: Gopi Venkatesh ,  James M. Clevenger

    Inventor： Gopi Venkatesh ,  James M. Clevenger

    IPC: A61K9/14

    CPC classification number: A61K31/135 ,  A61K9/0053 ,  A61K9/1652 ,  A61K9/2054 ,  A61K9/4808 ,  A61K9/4866 ,  A61K9/5078 ,  A61K31/137 ,  A61K31/5513 ,  Y10T29/49826

    Abstract: A unit dosage form, such as a capsule or the like, for delivering a skeletal muscle relaxant, such as cyclobenzaprine hydrochloride, into the body in an extended or sustained release fashion comprising one or more populations of drug-containing particles (beads, pellets, granules, etc.) is disclosed. At least one bead population exhibits a pre-designed sustained release profile. Such a drug delivery system is designed for once-daily oral administration to maintain an adequate plasma concentration-time profile, thereby providing relief of muscle spasm associated with painful musculoskeletal conditions over a 24 hour period.

    Abstract translation: 用于以延长或持续释放的方式将骨骼肌松弛剂（例如盐酸环苯扎林）输送到体内的单位剂型，包括一种或多种含药颗粒群（珠粒，丸粒， 颗粒等）。 至少一个珠粒表现出预先设计的持续释放特征。 这种药物递送系统设计为每日一次口服给药以维持足够的血浆浓度 - 时间特征，从而在24小时内缓解与疼痛的肌肉骨骼病症相关的肌肉痉挛。

    Modified Release Dosage Forms of Skeletal Muscle Relaxants
    10.
    发明申请
    Modified Release Dosage Forms of Skeletal Muscle Relaxants 有权
    骨骼肌松弛剂的改性释放剂量形式

    公开(公告)号：US20090017127A1

    公开(公告)日：2009-01-15

    申请号：US12236723

    申请日：2008-09-24

    Applicant: Gopi Venkatesh ,  James M. Clevenger

    Inventor： Gopi Venkatesh ,  James M. Clevenger

    IPC: A61K9/50 ,  A61P21/02

    CPC classification number: A61K31/135 ,  A61K9/0053 ,  A61K9/1652 ,  A61K9/2054 ,  A61K9/4808 ,  A61K9/4866 ,  A61K9/5078 ,  A61K31/137 ,  A61K31/5513 ,  Y10T29/49826

    Abstract: A unit dosage form, such as a capsule or the like, for delivering a skeletal muscle relaxant, such as cyclobenzaprine hydrochloride, into the body in an extended or sustained release fashion comprising one or more populations of drug-containing particles (beads, pellets, granules, etc.) is disclosed. At least one bead population exhibits a pre-designed sustained release profile. Such a drug delivery system is designed for once-daily oral administration to maintain an adequate plasma concentration - time profile, thereby providing relief of muscle spasm associated with painful musculoskeletal conditions over a 24 hour period.

    Abstract translation: 用于以延长或持续释放的方式将骨骼肌松弛剂（例如盐酸环苯扎林）输送到体内的单位剂型，包括一种或多种含药颗粒群（珠粒，丸粒， 颗粒等）。 至少一个珠粒表现出预先设计的持续释放特征。 这种药物递送系统设计为每日一次口服给药以维持足够的血浆浓度 - 时间特征，从而在24小时内缓解与疼痛肌肉骨骼病症相关的肌肉痉挛。

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