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    Modified release dosage forms of skeletal muscle relaxants
    1.
    发明授权
    Modified release dosage forms of skeletal muscle relaxants 有权
    骨骼肌松弛剂的改性释放剂型

    公开(公告)号：US07829121B2

    公开(公告)日：2010-11-09

    申请号：US12236719

    申请日：2008-09-24

    Applicant: Gopi Venkatesh ,  James M. Clevenger

    Inventor： Gopi Venkatesh ,  James M. Clevenger

    IPC: A61K9/14

    CPC classification number: A61K31/135 ,  A61K9/0053 ,  A61K9/1652 ,  A61K9/2054 ,  A61K9/4808 ,  A61K9/4866 ,  A61K9/5078 ,  A61K31/137 ,  A61K31/5513 ,  Y10T29/49826

    Abstract: A unit dosage form, such as a capsule or the like, for delivering a skeletal muscle relaxant, such as cyclobenzaprine hydrochloride, into the body in an extended or sustained release fashion comprising one or more populations of drug-containing particles (beads, pellets, granules, etc.) is disclosed. At least one bead population exhibits a pre-designed sustained release profile. Such a drug delivery system is designed for once-daily oral administration to maintain an adequate plasma concentration—time profile, thereby providing relief of muscle spasm associated with painful musculoskeletal conditions over a 24 hour period.

    Abstract translation: 用于以延长或持续释放的方式将骨骼肌松弛剂（例如盐酸环苯扎林）输送到体内的单位剂型，包括一种或多种含药颗粒群（珠粒，丸粒， 颗粒等）。 至少一个珠粒表现出预先设计的持续释放特征。 这种药物递送系统设计为每日一次口服给药以维持足够的血浆浓度 - 时间特征，从而在24小时内缓解与疼痛的肌肉骨骼病症相关的肌肉痉挛。

    Modified release dosage forms of skeletal muscle relaxants
    2.
    发明授权
    Modified release dosage forms of skeletal muscle relaxants 有权
    骨骼肌松弛剂的改性释放剂型

    公开(公告)号：US08877245B2

    公开(公告)日：2014-11-04

    申请号：US13570670

    申请日：2012-08-09

    Applicant: Gopi Venkatesh ,  James M. Clevenger

    Inventor： Gopi Venkatesh ,  James M. Clevenger

    IPC: A61K9/14 ,  A61K31/5513 ,  A61K9/50 ,  A61K31/137

    CPC classification number: A61K31/135 ,  A61K9/0053 ,  A61K9/1652 ,  A61K9/2054 ,  A61K9/4808 ,  A61K9/4866 ,  A61K9/5078 ,  A61K31/137 ,  A61K31/5513 ,  Y10T29/49826

    Abstract: A unit dosage form, such as a capsule or the like, for delivering a skeletal muscle relaxant, such as cyclobenzaprine hydrochloride, into the body in an extended or sustained release fashion comprising one or more populations of drug-containing particles (beads, pellets, granules, etc.) is disclosed. At least one bead population exhibits a pre-designed sustained release profile. Such a drug delivery system is designed for once—daily oral administration to maintain an adequate plasma concentration—time profile, thereby providing relief of muscle spasm associated with painful musculoskeletal conditions over a 24 hour period.

    Abstract translation: 用于以延长或持续释放的方式将骨骼肌松弛剂（例如盐酸环苯扎林）输送到体内的单位剂型，包括一种或多种含药颗粒群（珠粒，丸粒， 颗粒等）。 至少一个珠粒表现出预先设计的持续释放特征。 这种药物递送系统设计为每日一次口服给药以维持足够的血浆浓度 - 时间特征，从而在24小时内缓解与疼痛的肌肉骨骼病症相关的肌肉痉挛。

    Modified Release Dosage Forms of Skeletal Muscle Relaxants
    5.
    发明申请
    Modified Release Dosage Forms of Skeletal Muscle Relaxants 审中-公开
    骨骼肌松弛剂的改性释放剂量形式

    公开(公告)号：US20110217384A1

    公开(公告)日：2011-09-08

    申请号：US12872354

    申请日：2010-08-31

    Applicant: Gopi Venkatesh ,  James M. Clevenger

    Inventor： Gopi Venkatesh ,  James M. Clevenger

    IPC: A61K9/14 ,  A61K9/50 ,  A61K31/135 ,  A61P21/02

    CPC classification number: A61K31/135 ,  A61K9/0053 ,  A61K9/1652 ,  A61K9/2054 ,  A61K9/4808 ,  A61K9/4866 ,  A61K9/5078 ,  A61K31/137 ,  A61K31/5513 ,  Y10T29/49826

    Abstract: A unit dosage form, such as a capsule or the like, for delivering a skeletal muscle relaxant, such as cyclobenzaprine hydrochloride, into the body in an extended or sustained release fashion comprising one or more populations of drug-containing particles (beads, pellets, granules, etc.) is disclosed. At least one bead population exhibits a pre-designed sustained release profile. Such a drug delivery system is designed for once-daily oral administration to maintain an adequate plasma concentration—time profile, thereby providing relief of muscle spasm associated with painful musculoskeletal conditions over a 24 hour period.

    Abstract translation: 用于以延长或持续释放的方式将骨骼肌松弛剂（例如盐酸环苯扎林）输送到体内的单位剂型，包括一种或多种含药颗粒群（珠粒，丸粒， 颗粒等）。 至少一个珠粒表现出预先设计的持续释放特征。 这种药物递送系统设计为每日一次口服给药以维持足够的血浆浓度 - 时间特征，从而在24小时内缓解与疼痛的肌肉骨骼病症相关的肌肉痉挛。

    Modified release dosage forms of skeletal muscle relaxants
    7.
    发明授权
    Modified release dosage forms of skeletal muscle relaxants 有权
    骨骼肌松弛剂的改性释放剂型

    公开(公告)号：US07544372B2

    公开(公告)日：2009-06-09

    申请号：US12026887

    申请日：2008-02-06

    Applicant: Gopi Venkatesh ,  James M. Clevenger

    Inventor： Gopi Venkatesh ,  James M. Clevenger

    IPC: A61K9/14

    CPC classification number: A61K31/135 ,  A61K9/0053 ,  A61K9/1652 ,  A61K9/2054 ,  A61K9/4808 ,  A61K9/4866 ,  A61K9/5078 ,  A61K31/137 ,  A61K31/5513 ,  Y10T29/49826

    Abstract: A unit dosage form, such as a capsule or the like, for delivering a skeletal muscle relaxant, such as cyclobenzaprine hydrochloride, into the body in an extended or sustained release fashion comprising one or more populations of drug-containing particles (beads, pellets, granules, etc.) is disclosed. At least one bead population exhibits a pre-designed sustained release profile. Such a drug delivery system is designed for once-daily oral administration to maintain an adequate plasma concentration-time profile, thereby providing relief of muscle spasm associated with painful musculoskeletal conditions over a 24 hour period.

    Abstract translation: 用于以延长或持续释放的方式将骨骼肌松弛剂（例如盐酸环苯扎林）输送到体内的单位剂型，包括一种或多种含药颗粒群（珠粒，丸粒， 颗粒等）。 至少一个珠粒表现出预先设计的持续释放特征。 这种药物递送系统设计为每日一次口服给药以维持足够的血浆浓度 - 时间特征，从而在24小时内缓解与疼痛的肌肉骨骼病症相关的肌肉痉挛。

    Modified Release Dosage Forms of Skeletal Muscle Relaxants
    8.
    发明申请
    Modified Release Dosage Forms of Skeletal Muscle Relaxants 有权
    骨骼肌松弛剂的改性释放剂量形式

    公开(公告)号：US20090017127A1

    公开(公告)日：2009-01-15

    申请号：US12236723

    申请日：2008-09-24

    Applicant: Gopi Venkatesh ,  James M. Clevenger

    Inventor： Gopi Venkatesh ,  James M. Clevenger

    IPC: A61K9/50 ,  A61P21/02

    CPC classification number: A61K31/135 ,  A61K9/0053 ,  A61K9/1652 ,  A61K9/2054 ,  A61K9/4808 ,  A61K9/4866 ,  A61K9/5078 ,  A61K31/137 ,  A61K31/5513 ,  Y10T29/49826

    Abstract: A unit dosage form, such as a capsule or the like, for delivering a skeletal muscle relaxant, such as cyclobenzaprine hydrochloride, into the body in an extended or sustained release fashion comprising one or more populations of drug-containing particles (beads, pellets, granules, etc.) is disclosed. At least one bead population exhibits a pre-designed sustained release profile. Such a drug delivery system is designed for once-daily oral administration to maintain an adequate plasma concentration - time profile, thereby providing relief of muscle spasm associated with painful musculoskeletal conditions over a 24 hour period.

    Abstract translation: 用于以延长或持续释放的方式将骨骼肌松弛剂（例如盐酸环苯扎林）输送到体内的单位剂型，包括一种或多种含药颗粒群（珠粒，丸粒， 颗粒等）。 至少一个珠粒表现出预先设计的持续释放特征。 这种药物递送系统设计为每日一次口服给药以维持足够的血浆浓度 - 时间特征，从而在24小时内缓解与疼痛肌肉骨骼病症相关的肌肉痉挛。

    Method for using a radiation cured drug release controlling membrane
    10.
    发明授权
    Method for using a radiation cured drug release controlling membrane 失效
    使用辐射固化药物释放控制膜的方法

    公开(公告)号：US5545442A

    公开(公告)日：1996-08-13

    申请号：US463473

    申请日：1995-06-05

    Applicant: Gary Van Savage ,  James M. Clevenger

    Inventor： Gary Van Savage ,  James M. Clevenger

    IPC: A61K9/28 ,  C08F2/46 ,  C08J3/28 ,  C08J7/04

    CPC classification number: C08J3/28 ,  A61K9/2866 ,  C08J2301/28

    Abstract: This invention pertains to cross-linked hydrophilic polymeric films, the process of making such films, and their use. The films of this invention are produced by solubilizing a water-soluble polymer with a photosensitive or light degradable catalyst, optionally drying said solution, and exposing the solution to an energy source, particularly light. These films are suitable for use as a carrier for biologically active agents, such as pharmaceuticals, both human and veterinary, insecticides, and fertilizers; as hydrophilic membranes for separation processes; as bandages for wound treatment; as body implants or as coatings for such implants; and as coatings on glass, metal, wood or ceramics.

    Abstract translation: 本发明涉及交联的亲水聚合物膜，制备这种膜的方法及其用途。 本发明的膜通过用光敏或光可降解催化剂溶解水溶性聚合物，任选地干燥所述溶液，并将溶液暴露于能源，特别是光来制备。 这些膜适合用作生物活性剂的载体，例如药物，人和兽医，杀虫剂和肥料; 作为分离过程的亲水膜; 作为伤口治疗的绷带; 作为身体植入物或作为这种植入物的涂层; 以及作为玻璃，金属，木材或陶瓷上的涂层。

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