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公开(公告)号:US10064945B2
公开(公告)日:2018-09-04
申请号:US13891306
申请日:2013-05-10
申请人: GRÜNENTHAL GMBH
发明人: Lutz Barnscheid , Eric Galia , Anja Geißler , Jana Pätz , Sebastian Schwier , Julia Baronsky-Probst
IPC分类号: A61K47/10 , A61K31/137 , A61K9/20
摘要: A thermoformed, tamper-resistant pharmaceutical dosage form comprises: a) a pharmacologically active ingredient; b) a polyalkylene oxide having a weight average molecular weight of more than 200,000 g/mol; and c) a zinc component, wherein the content of said zinc component is at least 1 ppm, relative to the total weight of the pharmaceutical dosage form. When the pharmacologically active ingredient is effective against pain, the pharmaceutical dosage form may be used in a method of treating pain. When the pharmacologically active ingredient has abuse potential, the pharmaceutical dosage form may be used in a method of reducing the incidence of the abuse of said pharmacologically active ingredient.
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公开(公告)号:US09925146B2
公开(公告)日:2018-03-27
申请号:US14841829
申请日:2015-09-01
申请人: GRÜNENTHAL GMBH
发明人: Lutz Barnscheid , Eric Galia , Sebastian Schwier , Ulrike Bertram , Anja Geissler , Kornelia Griessmann , Johannes Bartholomäus
IPC分类号: A61K31/44 , A61K9/20 , A61K9/28 , A61K31/485
CPC分类号: A61K9/2013 , A61K9/20 , A61K9/2031 , A61K9/2054 , A61K9/2095 , A61K9/284 , A61K31/485
摘要: A thermoformed pharmaceutical dosage form having a breaking strength of at least 300 N, said dosage form comprising a pharmacologically active ingredient (A), a free physiologically acceptable acid (B) in an amount of from 0.001 wt.-% to 5.0 wt.-%, based on the total weight of the pharmaceutical dosage form, and a polyalkylene oxide (C) having a weight average molecular weight Mw of at least 200,000 g/mol.
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公开(公告)号:US09750701B2
公开(公告)日:2017-09-05
申请号:US14965935
申请日:2015-12-11
申请人: GRÜNENTHAL GMBH
发明人: Eugeen Marie Jozef Jans , Filip René Irena Kiekens , Jody Firmin Marceline Voorspoels , Anne Faure , Iris Ziegler , Elisabeth Arkenau-Maric , Lutz Barnscheid , Johannes Bartholomäus , Marc Frevel , Eric Galia , Andrea Schüessele
IPC分类号: A61K9/20 , A61K31/135 , A61K31/137
CPC分类号: A61K9/2072 , A61K9/2018 , A61K9/2031 , A61K9/2054 , A61K9/2059 , A61K31/135 , A61K31/137 , Y10T428/24479
摘要: The invention relates to a pharmaceutical dosage form, preferably with controlled release of a pharmacologically active compound (A) contained therein, the pharmaceutical dosage form very preferably being tamper-resistant and most preferably having a breaking strength B1 of at least 500 N in direction of extension E1 and having a breaking strength B2 of less than 500 N in direction of extension E2.
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