公开(公告)号：US09925146B2

公开(公告)日：2018-03-27

申请号：US14841829

申请日：2015-09-01

申请人： GRÜNENTHAL GMBH

发明人： Lutz Barnscheid ,  Eric Galia ,  Sebastian Schwier ,  Ulrike Bertram ,  Anja Geissler ,  Kornelia Griessmann ,  Johannes Bartholomäus

IPC分类号： A61K31/44 ,  A61K9/20 ,  A61K9/28 ,  A61K31/485

CPC分类号： A61K9/2013 ,  A61K9/20 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2095 ,  A61K9/284 ,  A61K31/485

摘要： A thermoformed pharmaceutical dosage form having a breaking strength of at least 300 N, said dosage form comprising a pharmacologically active ingredient (A), a free physiologically acceptable acid (B) in an amount of from 0.001 wt.-% to 5.0 wt.-%, based on the total weight of the pharmaceutical dosage form, and a polyalkylene oxide (C) having a weight average molecular weight Mw of at least 200,000 g/mol.