公开(公告)号：US20220118037A1

公开(公告)日：2022-04-21

申请号：US17499261

申请日：2021-10-12

申请人： GRAPE KING BIO LTD

发明人： Chin-Chu CHEN ,  I-Chen LI ,  Tsung-Ju LI ,  Ting-Yu LU ,  Yen-Po CHEN

IPC分类号： A61K36/07 ,  A61P21/06 ,  B01D11/02 ,  A23L33/10 ,  A23L31/00 ,  A23K50/50

摘要： The invention provides a method for improving sarcopenia of a subject in need thereof by using Phellinus linteus, in which the method includes administering an effective dose of composition to the subject, and the composition includes Phellinus linteus (NITE BP-03321 and BCRC 930210) as an effective substance. By using the aforementioned composition including an extract of a fermented product of the Phellinus linteus and/or its derivative, diameters of myotubes, amounts of muscles and muscle muscular endurance can be maintained, thereby improving sarcopenia.

公开(公告)号：US20220118036A1

公开(公告)日：2022-04-21

申请号：US17198928

申请日：2021-03-11

申请人： GRAPE KING BIO LTD.

发明人： Chin-Chu CHEN ,  I-Chen LI ,  Tsung-Ju LI ,  Ting-Yu LU ,  Lynn-Huey CHIANG ,  Yen-Po CHEN

IPC分类号： A61K36/062 ,  A61K9/19 ,  A61P21/06

摘要： The present invention provides a novel use of Morchella active substance. The Morchella active substance is for manufacturing a composition for ameliorating Sarcopenia. The preparation method of the Morchella active substance comprises the following steps: (a) culturing Morchella mycelium in a plate media between 15° C. and 30° C. for 1 to 2 weeks; (b) inoculating the Morchella mycelium cultured in step (a) to a flask and culturing the Morchella mycelium between 15° C. and 30° C. with a pH of 2 to 6 for 4 to 7 days; and (c) inoculating the Morchella mycelium cultured in step (b) to a fermentation tank and culturing the Morchella mycelium between 15° C. and 30° C. with a pH of 2 to 6 for 6 to 10 days, so as to obtain a Morchella mycelium fermentation broth containing the Morchella active substance.