公开(公告)号：US11944659B2

公开(公告)日：2024-04-02

申请号：US17499261

申请日：2021-10-12

申请人： GRAPE KING BIO LTD

发明人： Chin-Chu Chen ,  I-Chen Li ,  Tsung-Ju Li ,  Ting-Yu Lu ,  Yen-Po Chen

IPC分类号： A61K36/07 ,  A23K50/50 ,  A23L31/00 ,  A23L33/10 ,  A61P21/06 ,  B01D11/02

CPC分类号： A61K36/07 ,  A23K50/50 ,  A23L31/00 ,  A23L33/10 ,  A61P21/06 ,  B01D11/0288 ,  A23V2002/00 ,  A61K2236/11 ,  A61K2236/333 ,  A61K2236/37

摘要： The invention provides a method for improving sarcopenia of a subject in need thereof by using Phellinus linteus, in which the method includes administering an effective dose of composition to the subject, and the composition includes Phellinus linteus (NITE BP-03321 and BCRC 930210) as an effective substance. By using the aforementioned composition including an extract of a fermented product of the Phellinus linteus and/or its derivative, diameters of myotubes, amounts of muscles and muscle muscular endurance can be maintained, thereby improving sarcopenia.

公开(公告)号：US20230128854A1

公开(公告)日：2023-04-27

申请号：US17554626

申请日：2021-12-17

申请人： GRAPE KING BIO LTD

发明人： Chin-Chu CHEN ,  Yen-Lien CHEN ,  Shih-Wei LIN ,  Yen-Po CHEN ,  Ci-Sian WANG ,  Yu-Hsin HOU ,  Yang-Tzu SHIH ,  Ching-Wen LIN ,  Ya-Jyun CHEN ,  Jia-Lin JIANG ,  You-Shan TSAI ,  Zi-He WU

IPC分类号： A61K35/742 ,  A61P25/34 ,  A61K9/00 ,  C12N1/20

摘要： The present invention is related to a method of reducing tobacco addiction in a smoking subject with Lactobacillus fermentum GKF3, including daily administering an oral composition containing the Lactobacillus fermentum GKF3 to the smoking subject, in which the oral composition reduces the total amount of the nicotine metabolites in urine.

公开(公告)号：US11058733B2

公开(公告)日：2021-07-13

申请号：US16542608

申请日：2019-08-16

申请人： GRAPE KING BIO LTD

发明人： Chin-Chu Chen ,  Yen-Lien Chen ,  Shih-Wei Lin ,  Yen-Po Chen ,  Ci-Sian Wang ,  Yu-Hsin Hou ,  Yang-Tzu Shih ,  Ching-Wen Lin ,  Ya-Jyun Chen ,  Jia-Lin Jiang

IPC分类号： A61K35/745 ,  C12N1/20 ,  A61K9/00 ,  A23L33/135 ,  A61K35/00

摘要： The present invention provides a Bifidobacterium lactis having active substances, a composition comprising the same, and a method of promoting longevity using the same by subjecting the composition to a subject, thereby increasing Cisd2 gene expression, reducing damage of mitochondria, delaying aging-related symptoms including nerve degeneration and sarcopenia, and so on.

公开(公告)号：US10342833B2

公开(公告)日：2019-07-09

申请号：US15827453

申请日：2017-11-30

申请人： GRAPE KING BIO Ltd.

发明人： Pei-Cheng Lin ,  Han-Hsin Chang ,  Chin-Chu Chen ,  Yen-Lien Chen ,  Shu-Hsing Yeh ,  Li-Ya Lee ,  Jui-Hsia Hsu ,  Lee-Sar Sheng

IPC分类号： A61K49/00 ,  A01N63/00 ,  A61K39/00 ,  A61K36/068

摘要： The present invention discloses the Cordyceps cicadae mycelia, the active substances of C. cicadae mycelia, its submerged fermentation product and its pharmaceutical composition for preventing, delaying or treating cataracts, and the methods for preparing the products above. The C. cicadae mycelia, the active substances of C. cicadae mycelia, its submerged fermentation product and its pharmaceutical composition further can be prepared as a health food for preventing or delaying cataracts.

公开(公告)号：US20240165170A1

公开(公告)日：2024-05-23

申请号：US18117573

申请日：2023-03-06

申请人： GRAPE KING BIO LTD.

发明人： Chin-Chu CHEN ,  Yen-Lien CHEN ,  Shin-Wei LIN ,  You-Shan TSAI ,  Ci-Sian WANG ,  Yu-Hsin HOU ,  Yang-Tzu SHIH ,  Ching-Wen LIN ,  Ya-Jyun CHEN ,  Jia-Lin JIANG ,  Zi-He WU ,  Yen-Po CHEN ,  Tzu Chun LIN

IPC分类号： A61K35/744 ,  A23L33/00 ,  A23L33/135 ,  A61K35/747 ,  A61P1/04 ,  C12N1/20

CPC分类号： A61K35/744 ,  A23L33/135 ,  A23L33/40 ,  A61K35/747 ,  A61P1/04 ,  C12N1/20 ,  A61K2035/115

摘要： The present invention provides a method for preventing and/or treating a NSAID-induced gastric ulcer. The method comprises administrating an effective amount of a lactic acid bacterium set to a subject. The lactic acid bacterium set comprises Lactobacillus plantarum GKD7 and Pediococcus acidilactici GKA4.

公开(公告)号：US11752177B2

公开(公告)日：2023-09-12

申请号：US17554626

申请日：2021-12-17

申请人： GRAPE KING BIO LTD

发明人： Chin-Chu Chen ,  Yen-Lien Chen ,  Shih-Wei Lin ,  Yen-Po Chen ,  Ci-Sian Wang ,  Yu-Hsin Hou ,  Yang-Tzu Shih ,  Ching-Wen Lin ,  Ya-Jyun Chen ,  Jia-Lin Jiang ,  You-Shan Tsai ,  Zi-He Wu

IPC分类号： A61P25/34 ,  C12N1/20 ,  A61K9/00 ,  C12R1/225 ,  A61K35/742

CPC分类号： A61K35/742 ,  A61K9/0053 ,  A61P25/34 ,  C12N1/205 ,  C12R2001/225

摘要： The present invention is related to a method of reducing tobacco addiction in a smoking subject with Lactobacillus fermentum GKF3, including daily administering an oral composition containing the Lactobacillus fermentum GKF3 to the smoking subject, in which the oral composition reduces the total amount of the nicotine metabolites in urine.

公开(公告)号：US11116807B2

公开(公告)日：2021-09-14

申请号：US16019722

申请日：2018-06-27

申请人： GRAPE KING BIO LTD.

发明人： Chin-Chu Chen ,  Szu-Yin Wu ,  Hsiao-Ling Chang ,  Yen-Po Chen

IPC分类号： A61K36/062 ,  A61P15/08 ,  A61K9/19 ,  A61K47/10 ,  A61K9/08

摘要： The present invention provides an active substance of Morchella, its use and a composition thereof for improving disturbance of reproductive function, especially, for manufacturing a pharmaceutical composition to improve disturbance of reproductive function induced by obesity or metabolic syndrome. The composition with the active substance of Morchella can effectively improve the structural integrity of testicular tissues and sperm, increase testosterone levels in the blood, and reduce the oxidation stress in sperms.

公开(公告)号：US20200068815A1

公开(公告)日：2020-03-05

申请号：US16674209

申请日：2019-11-05

申请人： GRAPE KING BIO LTD.

发明人： Pei-Shan Liu ,  Chien-Chih Chen ,  Chin-Chu Chen ,  Li-Ya Lee ,  Wan-Ping Chen ,  Ting-Wei Lin ,  Jui-Hsia Hsu ,  Wei-Ching Chu

IPC分类号： A01G18/00 ,  A61K9/14 ,  A61K31/343 ,  A61K36/07 ,  C12P17/18 ,  C12R1/645 ,  C07D493/06

摘要： The present invention is related to an active substance of Hericium erinaceus having a pain-relieving effect, and a pharmaceutical composition including the active substance. The active substance is prepared using the following steps: (a) inoculating a mycelium of H. erinaceus on an agar plate and incubating at 15-32° C. for 8-16 days; (b) inoculating the incubated H. erinaceus mycelia from step (a) into a medium in a flask and incubating at 20-30° C. and pH 4.5-6.5 for 3-5 days; (c) inoculating the incubated H. erinaceus mycelia from step (b) into a medium in a fermentation tank and incubating at 24-32° C. and pH 4.5-5.5 for 8-16 days to obtain a fermented medium of the H. erinaceus mycelia; and (d) desiccating the fermented medium of the H. erinaceus mycelia from step (c) to obtain the powder of the H. erinaceus mycelia, which is further purified and isolated to obtain a novel compound of H. erinaceus.

公开(公告)号：US20200054691A1

公开(公告)日：2020-02-20

申请号：US16541964

申请日：2019-08-15

申请人： GRAPE KING BIO LTD.

发明人： Chin-Chu CHEN ,  Yen-Lien CHEN ,  Shin-Wei LIN ,  Yen-Po CHEN ,  Ci-Sian WANG ,  Yu-Hsin HOU ,  Yang-Tzu SHIH ,  Ching-Wen LIN ,  Ya-Jyun CHEN ,  Jia-Lin JIANG

IPC分类号： A61K35/745 ,  A23L33/135 ,  A23L2/52 ,  A61P11/06 ,  A61K9/19

摘要： The present invention provides a Bifidobacterium lactis GKK2, a composition comprising thereof and its use for improving asthma, especially for lowering airway resistance, reducing levels of non-specific and specific IgE in serum, alleviating bronchoconstriction and increasing levels of GSH reductase in liver tissue interstitial fluid to improve allergic asthma.

公开(公告)号：US20190008911A1

公开(公告)日：2019-01-10

申请号：US15827453

申请日：2017-11-30

申请人： GRAPE KING BIO Ltd.

发明人： Pei-Cheng Lin ,  Han-Hsin Chang ,  Chin-Chu Chen ,  Yen-Lien Chen ,  Shu-Hsing Yeh ,  Li-Ya Lee ,  Jui-Hsia Hsu ,  Lee-Sar Sheng

IPC分类号： A61K36/068

CPC分类号： A61K36/068 ,  A61K2236/00

摘要： The present invention discloses the Cordyceps cicadae mycelia, the active substances of C. cicadae mycelia, its submerged fermentation product and its pharmaceutical composition for preventing, delaying or treating cataracts, and the methods for preparing the products above. The C. cicadae mycelia, the active substances of C. cicadae mycelia, its submerged fermentation product and its pharmaceutical composition further can be prepared as a health food for preventing or delaying cataracts.