公开(公告)号：US20210228510A1

公开(公告)日：2021-07-29

申请号：US17207586

申请日：2021-03-19

申请人： GRI BIO, INC.

发明人： Georg Schlechtingen ,  Hans-Joachim Knolker ,  Tim Friedrichson ,  Gary Jennings ,  Tobias Braxmeier

IPC分类号： A61K31/164 ,  C07C237/08 ,  A61K45/06

摘要： The present invention relates to hydroxy-substituted amino and ammonium derivatives, in particular the compounds of formula 1 or 2, and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.

公开(公告)号：US20190175529A1

公开(公告)日：2019-06-13

申请号：US16208394

申请日：2018-12-03

申请人： GRI BIO, INC.

发明人： Georg Schlechtingen ,  Hans-Joachim Knolker ,  Tim Friedrichson ,  Gary Jennings ,  Tobias Braxmeier

IPC分类号： A61K31/164 ,  C07C237/08 ,  A61K45/06

摘要： The present invention relates to hydroxy-substituted amino and ammonium derivatives, in particular the compounds of formula (1) or (2), and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.

公开(公告)号：US11564895B2

公开(公告)日：2023-01-31

申请号：US17207586

申请日：2021-03-19

申请人： GRI BIO, INC.

发明人： Georg Schlechtingen ,  Hans-Joachim Knolker ,  Tim Friedrichson ,  Gary Jennings ,  Tobias Braxmeier

IPC分类号： A61K45/06 ,  A61K31/164 ,  C07C237/08

摘要： The present invention relates to hydroxy-substituted amino and ammonium derivatives, in particular the compounds of formula 1 or 2, and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.

公开(公告)号：US11453642B2

公开(公告)日：2022-09-27

申请号：US17080636

申请日：2020-10-26

申请人： GRI BIO, INC.

发明人： Georg Schlechtingen ,  Hans-Joachim Knolker ,  Tim Friedrichson ,  Gary Jennings ,  Tobias Braxmeier

IPC分类号： A61K31/205 ,  C07C309/14

摘要： The present invention relates to oxygenated amino and ammonium-containing sulfonic acid, phosphonic acid and carboxylic acid derivatives, in particular the compounds of formula 1, 2, 3, 4, 5 or 6, and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.

公开(公告)号：US20210114979A1

公开(公告)日：2021-04-22

申请号：US17080636

申请日：2020-10-26

申请人： GRI BIO, INC.

发明人： Georg Schlechtingen ,  Hans-Joachim Knolker ,  Tim Friedrichson ,  Gary Jennings ,  Tobias Braxmeier

IPC分类号： C07C309/14 ,  A61K31/205

摘要： The present invention relates to oxygenated amino and ammonium-containing sulfonic acid, phosphonic acid and carboxylic acid derivatives, in particular the compounds of formula 1, 2, 3, 4, 5 or 6, and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.

公开(公告)号：US20170369430A1

公开(公告)日：2017-12-28

申请号：US15694303

申请日：2017-09-01

申请人： GRI BIO, INC.

发明人： Georg Schlechtingen ,  Hans-Joachim Knolker ,  Tim Friedrichson ,  Gary Jennings ,  Tobias Braxmeier

IPC分类号： C07C309/14 ,  A61K31/205

摘要： The present invention relates to oxygenated amino or ammonium-containing sulfonic acid, phosphoric acid and carboxylic acid derivatives, in particular the compounds of formula 1, 2, 3, 4, 5 or 6, and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dys-plastic disease or disorder.

公开(公告)号：US20170157070A1

公开(公告)日：2017-06-08

申请号：US15436678

申请日：2017-02-17

申请人： GRI BIO, INC.

发明人： Georg Schlechtingen ,  Hans-Joachim Knolker ,  Tim Friedrichson ,  Gary Jennings ,  Tobias Braxmeier

IPC分类号： A61K31/164 ,  A61K45/06

CPC分类号： C07C237/08 ,  A61K31/164 ,  A61K45/06

摘要： The present invention relates to hydroxy-substituted amino and ammonium derivatives, in particular the compounds of formula (1) or (2), and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.

公开(公告)号：US10952977B2

公开(公告)日：2021-03-23

申请号：US16208394

申请日：2018-12-03

申请人： GRI BIO, INC.

发明人： Georg Schlechtingen ,  Hans-Joachim Knolker ,  Tim Friedrichson ,  Gary Jennings ,  Tobias Braxmeier

IPC分类号： A61K31/164 ,  C07C237/08 ,  A61K45/06

摘要： The present invention relates to hydroxy-substituted amino and ammonium derivatives, in particular the compounds of formula (1) or (2), and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.

公开(公告)号：US10815195B2

公开(公告)日：2020-10-27

申请号：US15694303

申请日：2017-09-01

申请人： GRI BIO, INC.

发明人： Georg Schlechtingen ,  Hans-Joachim Knolker ,  Tim Friedrichson ,  Gary Jennings ,  Tobias Braxmeier

IPC分类号： C07C309/14 ,  A61K31/205

摘要： The present invention relates to oxygenated amino or ammonium-containing sulfonic acid, phosphoric acid and carboxylic acid derivatives, in particular the compounds of formula 1, 2, 3, 4, 5 or 6, and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.

公开(公告)号：US10143668B2

公开(公告)日：2018-12-04

申请号：US15436678

申请日：2017-02-17

申请人： GRI BIO, INC.

发明人： Georg Schlechtingen ,  Hans-Joachim Knolker ,  Tim Friedrichson ,  Gary Jennings ,  Tobias Braxmeier

IPC分类号： A61K31/164 ,  C07C237/08 ,  A61K45/06

摘要： The present invention relates to hydroxy-substituted amino and ammonium derivatives, in particular the compounds of formula (1) or (2), and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.