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公开(公告)号：US20240092736A1
公开(公告)日：2024-03-21
申请号：US17773171
申请日：2020-10-29
发明人： Daniel S. Kohane , Yueqin Zheng
IPC分类号： C07D211/60 , A61P23/02 , C07C237/08 , C07C237/10 , C07C237/12
CPC分类号： C07D211/60 , A61P23/02 , C07C237/08 , C07C237/10 , C07C237/12
摘要： Provided herein are compounds that are local anesthetics and useful for inducing selective sensory nerve blockade. Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of inducing selective sensory nerve blockade by administering the compounds and/or compositions to a subject.
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2.发明授权公开(公告)号：US11685739B2
公开(公告)日：2023-06-27
申请号：US17396975
申请日：2021-08-09
发明人： Chongxi Yu , Lina Xu
IPC分类号： C07D471/04 , C07C271/16 , C07C271/22 , C07D321/12 , C07C219/10 , C07C219/14 , C07C219/28 , C07C229/12 , C07C327/30 , C07C229/58 , C07D455/02 , C07C237/06 , C07C237/20 , C07D207/16 , C07K5/083 , C07D211/62 , C07K5/097 , A61K31/137 , C07C229/36 , A61K31/195 , A61K31/198 , A61K31/277 , C07C317/44 , A61K31/197 , A61K31/24 , A61K31/40 , C07C219/06 , C07C219/32 , C07C237/08 , C07C327/36 , C07C217/60
CPC分类号： C07D471/04 , A61K31/137 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/24 , A61K31/277 , A61K31/40 , C07C217/60 , C07C219/06 , C07C219/10 , C07C219/14 , C07C219/28 , C07C219/32 , C07C229/12 , C07C229/36 , C07C229/58 , C07C237/06 , C07C237/08 , C07C237/20 , C07C271/16 , C07C271/22 , C07C317/44 , C07C327/30 , C07C327/36 , C07D207/16 , C07D211/62 , C07D321/12 , C07D455/02 , C07K5/0806 , C07K5/0823 , C07C2602/08 , A61K31/198 , A61K2300/00 , A61K31/195 , A61K2300/00 , A61K31/137 , A61K2300/00 , A61K31/277 , A61K2300/00
摘要： One aspect of the invention provides a composition of novel high penetration compositions (HPC) or a high penetration prodrug (HPP) for treatment of Parkinson's disease. The HPCs/HPPs are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, the HPPs are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPCs/HPPs can be administered to a subject through various administration routes, e.g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.
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公开(公告)号：US20220081392A1
公开(公告)日：2022-03-17
申请号：US16608610
申请日：2018-04-27
发明人： Xinyao DU , Steven M. ANSELL
IPC分类号： C07C237/08 , C07C237/06 , A61K9/51
摘要： Compounds are provided having one of the following structures (I) or (II): or (I) (II) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R3a, R3b, L1, L2, G1a, G1b, G2a, G2b and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
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4.发明申请公开(公告)号：US20220064157A1
公开(公告)日：2022-03-03
申请号：US17396975
申请日：2021-08-09
发明人： Chongxi Yu , Lina Xu
IPC分类号： C07D471/04 , C07C271/16 , C07C271/22 , C07D321/12 , C07C219/10 , C07C219/14 , C07C219/28 , C07C229/12 , C07C327/30 , C07C229/58 , C07D455/02 , C07C237/06 , C07C237/20 , C07D207/16 , C07K5/083 , C07D211/62 , C07K5/097 , A61K31/137 , C07C229/36 , A61K31/195 , A61K31/198 , A61K31/277 , C07C317/44 , A61K31/197 , A61K31/24 , A61K31/40 , C07C219/06 , C07C219/32 , C07C237/08 , C07C327/36 , C07C217/60
摘要： One aspect of the invention provides a composition of novel high penetration compositions (HPC) or a high penetration prodrug (HPP) for treatment of Parkinson's disease. The HPCs/HPPs are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, the HPPs are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPCs/HPPs can be administered to a subject through various administration routes, e.g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.
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公开(公告)号：US20210163403A1
公开(公告)日：2021-06-03
申请号：US17145152
申请日：2021-01-08
IPC分类号： C07C237/08 , A61K31/165 , A61K45/06 , A61K31/397 , A61K31/40 , A61K31/416 , A61K31/417 , A61K31/445 , A61K31/45 , C07D231/56 , C07D233/64 , C07D205/04 , C07D211/60 , C12Q1/68 , C07C237/22 , A61K31/4164 , C07C259/06 , C12Q1/6886 , C07D207/16 , C07D211/78 , A61P35/00 , C07C233/31 , C07D207/09 , C07D211/76
摘要： Provided herein are compositions and methods for treating, inhibiting and/or reducing the severity of cancer in subjects in need thereof. The methods include providing an agent that inhibits expression or activity of ONECUT2 and administering a therapeutically effective amount of the agent so as to treat, inhibit and/or reduce the severity of cancer in the subject.
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公开(公告)号：US10952977B2
公开(公告)日：2021-03-23
申请号：US16208394
申请日：2018-12-03
申请人： GRI BIO, INC.
发明人： Georg Schlechtingen , Hans-Joachim Knolker , Tim Friedrichson , Gary Jennings , Tobias Braxmeier
IPC分类号： A61K31/164 , C07C237/08 , A61K45/06
摘要： The present invention relates to hydroxy-substituted amino and ammonium derivatives, in particular the compounds of formula (1) or (2), and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.
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公开(公告)号：US20200330501A1
公开(公告)日：2020-10-22
申请号：US16867291
申请日：2020-05-05
发明人： Yizhou Dong , Kevin Love , Robert S. Langer , Daniel Griffith Anderson , Delai Chen , Yi Chen , Arturo Jose Vegas , Akinleye C. Alabi , Yunlong Zhang
IPC分类号： A61K31/7105 , C07D233/64 , C07D403/06 , C07D241/08 , C07C229/12 , C07C229/22 , C07C229/26 , C07D487/06 , C07D207/16 , C07D209/20 , C07C271/22 , C07C229/36 , C07C237/08 , C07C237/12 , C12N15/88 , C12N15/87 , C07C229/24 , C07C279/14 , C07C323/58 , C07D209/24 , C07D265/32 , C07D413/06 , C07D487/04 , C12Q1/02 , G01N33/15 , A61K31/711 , A61K47/22
摘要： Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.
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公开(公告)号：US10682374B2
公开(公告)日：2020-06-16
申请号：US16126897
申请日：2018-09-10
发明人： Yizhou Dong , Kevin Thomas Love , Robert S. Langer , Daniel Griffith Anderson , Delai Chen , Yi Chen , Arturo Jose Vegas , Akinleye C. Alabi , Yunlong Zhang
IPC分类号： A61K31/7105 , C07D233/64 , C07D403/06 , C07D241/08 , C07C229/12 , C07C229/22 , C07C229/26 , C07D487/06 , C07D207/16 , C07D209/20 , C07C271/22 , C07C229/36 , C07C237/08 , C07C237/12 , C12N15/88 , C12N15/87 , C07C229/24 , C07C279/14 , C07C323/58 , C07D209/24 , C07D265/32 , C07D413/06 , C07D487/04 , C12Q1/02 , G01N33/15 , A61K31/711 , A61K47/22
摘要： Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.
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公开(公告)号：US20190330516A1
公开(公告)日：2019-10-31
申请号：US16509057
申请日：2019-07-11
申请人： CHINA PETROLEUM & CHEMICAL CORPORATION , SHANGHAI RESEARCH INSTITUTE OF PETROCHEMICAL TECHNOLOGY, SINOPEC
发明人： Yingcheng LI , Songyuan GU , Weidong ZHANG , Xinning BAO , Ou SHA , Zhiqin SHEN , Yiqing YANG , Xiaodong ZHAI
IPC分类号： C09K8/584 , C09K8/60 , C07C233/36 , C07C217/08 , C07C309/10 , C07C233/05 , C07C303/22 , C07C231/14 , C07C233/09 , C07C237/08 , C07C237/40 , C07C213/06
摘要： This invention relates to an anionic-cationic-nonionic surfactant as substantially represented by the formula (I), production and use thereof in tertiary oil recovery. The anionic-cationic-nonionic surfactant of this invention exhibits significantly improved interfacial activity and stability as compared with the prior art. With the present anionic-cationic-nonionic surfactant, a flooding fluid composition for tertiary oil recovery with improved oil displacement efficiency and oil washing capability as compared with the prior art could be produced. In the formula (I), each group is as defined in the specification.
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公开(公告)号：US10143668B2
公开(公告)日：2018-12-04
申请号：US15436678
申请日：2017-02-17
申请人： GRI BIO, INC.
发明人： Georg Schlechtingen , Hans-Joachim Knolker , Tim Friedrichson , Gary Jennings , Tobias Braxmeier
IPC分类号： A61K31/164 , C07C237/08 , A61K45/06
摘要： The present invention relates to hydroxy-substituted amino and ammonium derivatives, in particular the compounds of formula (1) or (2), and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.
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