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公开(公告)号：US20210024619A1
公开(公告)日：2021-01-28
申请号：US16640819
申请日：2018-08-22
Applicant: GRIFFITH UNIVERSITY
Inventor： Michael F. GOOD , Manisha PANDEY , Michael Raymond BATZLOFF
Abstract: A modified p145 peptide having enhanced mucosal immunogenicity for use in eliciting a mucosal immune response to group A Streptococcal bacteria in a mammal such as a human. Intramuscular administration of the modified p145 5 peptide may be particularly efficacious. An S2 peptide or variant may be co-administered with the modified p145 peptide to enhance the immune response.
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公开(公告)号：US20230382981A1
公开(公告)日：2023-11-30
申请号：US18201595
申请日：2023-05-24
Applicant: GRIFFITH UNIVERSITY
Inventor： Michael F. GOOD , Manisha PANDEY , Michael Raymond BATZLOFF
CPC classification number: C07K16/1271 , A61K9/0019 , A61K38/16 , A61K39/116 , A61K39/092 , A61K47/646 , C07K14/315
Abstract: A modified p145 peptide having enhanced mucosal immunogenicity for use in eliciting a mucosal immune response to group A streptococcal bacteria in a mammal such as a human. Intramuscular administration of the modified p145 peptide may be particularly efficacious. An S2 peptide or variant may be co-administered with the modified p145 peptide to enhance the immune response.
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公开(公告)号：US20210292398A1
公开(公告)日：2021-09-23
申请号：US17055294
申请日：2019-05-16
Applicant: GRIFFITH UNIVERSITY
Inventor： Michael GOOD , Manisha PANDEY
IPC: C07K16/12 , A61P31/04 , C07K14/315
Abstract: Provided herein are methods of immunizing against, treating or preventing streptococcal toxic shock syndrome in a subject, by administration of a group A Streptococcus M protein, inclusive of fragments, variants or derivatives thereof, or an antibody that binds, or is raised against the M protein and optionally a group A Streptococcus superantigen protein, inclusive of fragments, variants or derivatives thereof, or an antibody or antibody fragment that binds, or is raised against, the superantigen protein.
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