公开(公告)号：US20240109886A1

公开(公告)日：2024-04-04

申请号：US18263481

申请日：2022-01-28

Applicant: GRIFFITH UNIVERSITY

Inventor： Mark VON ITZSTEIN ,  Ibrahim EL-DEEB ,  Patrice GUILLON ,  Larissa HEILIG

IPC: C07D471/04 ,  A61P31/16 ,  C07D487/04 ,  C07D495/04

CPC classification number: C07D471/04 ,  A61P31/16 ,  C07D487/04 ,  C07D495/04

Abstract: The present invention relates to a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and to pharmaceutical compositions comprising the compound. In Formula (I), rings W, X, Y and Z may relate to various heterocyclic, heteroaryl, cycloalkyl, cycloalkenyl, and/or aryl rings. The present invention also relates to uses of the compounds in treating a disease, disorder or condition caused by viral infection. (I) R3 is selected from the group consisting of:

公开(公告)号：US20200261440A1

公开(公告)日：2020-08-20

申请号：US16755328

申请日：2018-10-12

Applicant: THE UNIVERSITY OF QUEENSLAND ,  THE UNIVERSITY OF ADELAIDE ,  GRIFFITH UNIVERSITY

Inventor： Mark WALKER ,  Christopher MCDEVITT ,  Mark VON ITZSTEIN ,  Alastair MCEWAN

IPC: A61K31/473 ,  A61K45/06 ,  A61K38/12 ,  A61K33/30 ,  A61P31/04

Abstract: This invention relates to the use of zinc(II) salts in combination with a zinc ionophore to resensitize a previously resistant pathogenic bacteria to an antibiotic. Methods of restoring the sensitivity of a resistant pathogenic bacterium to an antibiotic comprising administering a zinc ionophore in combination with a zinc(II) salt and methods of treating a bacterial infection comprising administering a zinc ionophore in combination with a zinc (II) salt concurrently and/or sequentially with administration of a therapeutically effective amount of an antibiotic is also described.