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公开(公告)号：US20210393848A1
公开(公告)日：2021-12-23
申请号：US17267024
申请日：2019-12-20
摘要： Disclosed is absorbable bone wax and a preparation method thereof. The preparation method comprises the steps of: 1) mixing polyoxypropylene polyoxyethylene block copolymer (PEG-PPG-PEG) and polyoxypropylene polyoxyethylene random copolymer (PEG-PPG), and stirring evenly under heating to obtain a liquid mixture; 2) under mechanical stirring and heating condition, adding hemostatic starch microspheres to the liquid mixture obtained in step 1) to obtain a uniformly-mixed liquid; and 3) adding a bone repair material to the uniformly-mixed liquid obtained in step 2), and mixing uniformly to obtain a mixed solution, then pouring the mixed solution into a mold or sub-packaged bottle, and leaving at room temperature for solidifying and shaping to give the absorbable bone wax. The absorbable bone wax of the present invention can achieve the effect of rapid hemostasis, changing the relatively single hemostasis method with traditional bone wax which only depends on physical sealing.
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公开(公告)号：US11890392B2
公开(公告)日：2024-02-06
申请号：US17267024
申请日：2019-12-20
CPC分类号： A61L24/0042 , A61L24/0015 , A61L24/02 , A61L24/06 , C08L3/02 , C08L87/005 , A61L2300/104 , A61L2300/204 , A61L2400/04 , A61L2430/02
摘要： Disclosed is absorbable bone wax and a preparation method thereof. The preparation method comprises the steps of: 1) mixing polyoxypropylene polyoxyethylene block copolymer (PEG-PPG-PEG) and polyoxypropylene polyoxyethylene random copolymer (PEG-PPG), and stirring evenly under heating to obtain a liquid mixture; 2) under mechanical stirring and heating condition, adding hemostatic starch microspheres to the liquid mixture obtained in step 1) to obtain a uniformly-mixed liquid; and 3) adding a bone repair material to the uniformly-mixed liquid obtained in step 2), and mixing uniformly to obtain a mixed solution, then pouring the mixed solution into a mold or sub-packaged bottle, and leaving at room temperature for solidifying and shaping to give the absorbable bone wax. The absorbable bone wax of the present invention can achieve the effect of rapid hemostasis, changing the relatively single hemostasis method with traditional bone wax which only depends on physical sealing.
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3.发明申请公开(公告)号：US20210162093A1
公开(公告)日：2021-06-03
申请号：US17172103
申请日：2021-02-10
发明人： Rui Guo , Yong Lan , Yu Liu , Longbao Feng , Yu Chen
摘要： The invention discloses absorbable bone wax having a function of promoting bone repair and a preparation method thereof, falling within the technical field of biomedical materials. The absorbable bone wax comprises the following components in mass percentage: 10%˜50% polyoxypropylene polyoxyethylene block copolymer, 50%˜90% polyoxypropylene polyoxyethylene random copolymer, 0%˜20% strontium substituted hydroxyapatite and 0%˜20% microcrystalline cellulose. The absorbable bone wax has good biocompatibility and degradability, can provide good physiological conditions for absorption in vivo, has excellent mechanical and hemostatic properties, and promotes bone repair.
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