公开(公告)号：US20240269341A1

公开(公告)日：2024-08-15

申请号：US18646839

申请日：2024-04-26

申请人： Guangzhou Bioseal Biotech Co., Ltd.

发明人： Shuang Chen ,  Yufu Li ,  Dengmin Feng ,  Xiang Wan

IPC分类号： A61L24/10 ,  A61K9/16 ,  A61K31/717 ,  A61K38/36 ,  A61K38/48 ,  A61K47/18 ,  A61L24/00 ,  A61L24/02 ,  A61L24/08 ,  C08J3/12

CPC分类号： A61L24/108 ,  A61K9/16 ,  A61K9/1611 ,  A61K9/1682 ,  A61K31/717 ,  A61K38/363 ,  A61K38/4833 ,  A61K47/18 ,  A61L24/0042 ,  A61L24/02 ,  A61L24/08 ,  A61L24/106 ,  C08J3/12 ,  C12Y304/21005 ,  A61L2300/232 ,  A61L2300/252 ,  A61L2300/418 ,  A61L2300/802 ,  A61L2400/04 ,  A61L2430/36 ,  C08J2301/02 ,  C08J2389/00

摘要： The present invention is directed to hemostatic compositions comprising at least partially integrated agglomerated ORC fibers, fibrinogen, and thrombin and methods of forming a powdered hemostatic composition, comprising the steps of: forming a suspension of a mixture comprising particles of fibrinogen, thrombin, ORC fibers in a non-aqueous low boiling solvent; spraying the suspension through a nozzle onto a substrate, allowing the non-aqueous solvent to evaporate; separating from the substrate and sieving the composition.

公开(公告)号：US20240091402A1

公开(公告)日：2024-03-21

申请号：US18502950

申请日：2023-11-06

申请人： Arsenal Medical, Inc.

发明人： Jeffrey Groom ,  Craig Wiltsey ,  Quynh Pham ,  Nikhita Mansukhani ,  Courtney Guertin ,  Lee Core ,  Upma Sharma

IPC分类号： A61L24/06 ,  A61K47/02 ,  A61K47/34 ,  A61K49/04 ,  A61L24/00 ,  A61L24/02 ,  A61L24/04 ,  C08L83/04

CPC分类号： A61L24/06 ,  A61K47/02 ,  A61K47/34 ,  A61K49/04 ,  A61K49/0409 ,  A61L24/0021 ,  A61L24/02 ,  A61L24/043 ,  A61L24/046 ,  C08L83/04 ,  A61L2400/06 ,  A61L2430/36

摘要： The present disclosure pertains to crosslinkable compositions and systems as well as methods for forming crosslinked compositions in situ, including the use of the same for embolizing vasculature including the neurovasculature within a patient, among many other uses.

公开(公告)号：US11890392B2

公开(公告)日：2024-02-06

申请号：US17267024

申请日：2019-12-20

申请人： GUANGZHOU BEOGENE BIOTECHNOLOGY CO., LTD.

发明人： Yong Lan ,  Yu Liu ,  Yu Chen

IPC分类号： A61L24/00 ,  A61L24/02 ,  A61L24/06 ,  C08L87/00 ,  C08L3/02

CPC分类号： A61L24/0042 ,  A61L24/0015 ,  A61L24/02 ,  A61L24/06 ,  C08L3/02 ,  C08L87/005 ,  A61L2300/104 ,  A61L2300/204 ,  A61L2400/04 ,  A61L2430/02

摘要： Disclosed is absorbable bone wax and a preparation method thereof. The preparation method comprises the steps of: 1) mixing polyoxypropylene polyoxyethylene block copolymer (PEG-PPG-PEG) and polyoxypropylene polyoxyethylene random copolymer (PEG-PPG), and stirring evenly under heating to obtain a liquid mixture; 2) under mechanical stirring and heating condition, adding hemostatic starch microspheres to the liquid mixture obtained in step 1) to obtain a uniformly-mixed liquid; and 3) adding a bone repair material to the uniformly-mixed liquid obtained in step 2), and mixing uniformly to obtain a mixed solution, then pouring the mixed solution into a mold or sub-packaged bottle, and leaving at room temperature for solidifying and shaping to give the absorbable bone wax. The absorbable bone wax of the present invention can achieve the effect of rapid hemostasis, changing the relatively single hemostasis method with traditional bone wax which only depends on physical sealing.

公开(公告)号：US11884542B2

公开(公告)日：2024-01-30

申请号：US16322195

申请日：2017-08-01

申请人： B. BRAUN SURGICAL, S.A. ,  UNIVERSITAT POLITÉCNICA DE CATALUNYA

发明人： Pau Turon Dols ,  Luis Javier Del Valle Mendoza ,  Jordi Puiggalí Bellalta ,  Carlos Enrique Alemán Llansó

IPC分类号： A61K47/02 ,  A61L24/02 ,  A61L27/12 ,  C01B25/32 ,  B01J20/04 ,  B01J27/18 ,  B01J35/00 ,  C08K3/32 ,  H01M10/0562

CPC分类号： C01B25/327 ,  A61K47/02 ,  A61L24/02 ,  A61L27/12 ,  B01J20/048 ,  B01J27/1806 ,  B01J35/0033 ,  C08K3/32 ,  H01M10/0562 ,  C01P2002/72 ,  C01P2002/85 ,  C01P2004/03 ,  C01P2006/40 ,  C08K2003/325 ,  H01M2300/0068

摘要： The present invention relates to a permanently polarized hydroxyapatite and a composition or material comprising thereof. The present invention further relates to a process for obtaining a permanently polarized hydroxyapatite and to different uses of the permanently polarized hydroxyapatite or the composition or material comprising thereof.

公开(公告)号：US20240001134A1

公开(公告)日：2024-01-04

申请号：US18216258

申请日：2023-06-29

申请人： Novocure GmbH

发明人： Yoram WASSERMAN ,  Stas OBUCHOVSKY ,  Nataliya KUPLENNIK ,  David SHAPIRO

IPC分类号： A61N1/40 ,  H01B1/24 ,  A61L24/02 ,  A61L24/00 ,  A61K9/00

CPC分类号： A61N1/40 ,  H01B1/24 ,  A61L24/02 ,  A61L24/001 ,  A61L24/0078 ,  A61K9/0009 ,  A61L2400/00

摘要： An adhesive layer for use in a transducer apparatus, the adhesive layer extending in an x-y plane and having an adhesive layer outer edge, the adhesive layer including: an adhesive matrix material; a plurality of electrically conductive particles embedded at least partially within the adhesive matrix material forming a conductive adhesive region of the adhesive layer; and at least one non-conductive edge portion comprising an adhesive devoid of electrically conductive particles, the at least one non-conductive edge portion being electrically non-conductive; wherein, when viewed in a direction perpendicular to the x-y plane, a first non-conductive edge portion is located adjacent to and extends along an outer edge of the conductive adhesive region and forms at least a portion of an outer perimeter of the adhesive layer.

公开(公告)号：US20230321317A1

公开(公告)日：2023-10-12

申请号：US18209972

申请日：2023-06-14

申请人： CTL Medical Corporation

发明人： Sean SUH ,  Jon SUH ,  Danny CHON

IPC分类号： A61L24/00 ,  A61L24/02

CPC分类号： A61L24/0042 ,  A61L24/02 ,  A61L24/0015 ,  A61L2430/38 ,  A61L2300/412

摘要： Disclosed are devices, systems and related surgical methods including implantable devices having a plurality of osteo-inductive, osteoconductive and/or osseointegrative surface features that may be useful in joint and/or bone replacement implants used in spinal surgeries, dental surgeries and/or other orthopedic and/or general surgical procedures.

公开(公告)号：US11712495B2

公开(公告)日：2023-08-01

申请号：US17167492

申请日：2021-02-04

申请人： Omrix Biopharmaceuticals Ltd. ,  Ethicon, Inc.

发明人： Erez Ilan ,  Omri Faingold ,  Nataly Freizus ,  Ronen Eavri ,  Dwayne Looney ,  Sridevi Dhanaraj ,  James Galloway ,  Walter Danker

IPC分类号： A61L26/00 ,  A61L24/00 ,  A61L24/04 ,  A61L24/06 ,  A61L24/02 ,  A61L24/08

CPC分类号： A61L26/0023 ,  A61L24/001 ,  A61L24/0015 ,  A61L24/02 ,  A61L24/043 ,  A61L24/06 ,  A61L24/08 ,  A61L26/00 ,  A61L26/0004 ,  A61L2300/106 ,  A61L2300/232 ,  A61L2300/25 ,  A61L2300/418 ,  A61L2300/802 ,  A61L2400/04 ,  A61L24/043 ,  C08L1/04 ,  A61L24/06 ,  C08L1/04

摘要： The invention relates to a hemostatic composition comprising a mixture of cellulose-based short and long fibers, preparation and use thereof.

公开(公告)号：US20230180762A1

公开(公告)日：2023-06-15

申请号：US17947370

申请日：2022-09-19

申请人： SOLOMON ROSENBLATT

发明人： Solomon ROSENBLATT ,  John P. KENNEDY ,  Curtis E. JONES

IPC分类号： A01N59/12 ,  A01N31/02 ,  C08L29/04 ,  C08J9/26 ,  A61M1/00 ,  A61L24/00 ,  A61L24/02 ,  A61L24/04

CPC分类号： A01N59/12 ,  A01N31/02 ,  C08L29/04 ,  C08J9/26 ,  A61M1/71 ,  A61M1/915 ,  A61M1/92 ,  A61L24/0015 ,  A61L24/0036 ,  A61L24/02 ,  A61L24/043 ,  C08J2329/04 ,  C08J2201/026 ,  A61L2300/106 ,  A61L2300/404

摘要： A biocompatible controlled release form of complexed iodine is achieved by a complexation of polyvinyl alcohol based foam and characterized by a residual starch component to optimize iodine release profiles. The resulting iodine complexed polyvinyl alcohol foam may be utilized locally as an antimicrobial agent that releases controlled amounts of iodine sufficient to kill microbes for extended durations without excessive bulk and rigidity.

公开(公告)号：US20180264165A1

公开(公告)日：2018-09-20

申请号：US15982686

申请日：2018-05-17

申请人： Pioneer Surgical Technology, Inc.

发明人： Juchui Ray Lin ,  Edward S. Ahn ,  Brian M. Schlossberg

IPC分类号： A61L24/06 ,  A61K6/033 ,  A61L24/04 ,  A61K6/083 ,  A61K6/08 ,  A61L24/02

CPC分类号： A61L24/06 ,  A61K6/033 ,  A61K6/08 ,  A61K6/083 ,  A61L24/02 ,  A61L24/04 ,  A61L24/046 ,  A61L2300/112 ,  A61L2300/412 ,  A61L2400/06 ,  A61L2400/12 ,  A61L2430/02 ,  A61L2430/12

摘要： Disclosed are cement products, methods of forming cement using the cement product, and methods of using the cement product in orthopedic and dental applications. Generally, the disclosed cement product includes a first component and a second component. The first component comprises a polymerizable resin comprising ethylenic unsaturated double bond, a suitable glycidyl group and/or a suitable isocyanate group. The second component includes a compound comprising more than one type of amine selected from the group consisting of primary amine, secondary amines, tertiary amines and quaternary amines. Alternatively, the second component includes a compound comprising a suitable mercapto (SH—) group, a hindered amine or a dimethylthiotoluenediamine (DMTDA). Optionally, the cement product includes a filler and/or a bioactive component to promote bone formation.

公开(公告)号：US20180221159A1

公开(公告)日：2018-08-09

申请号：US15945403

申请日：2018-04-04

申请人： ZIMMER KNEE CREATIONS, INC.

发明人： Peter F. Sharkey ,  Charles F. Leinberry

IPC分类号： A61F2/38 ,  A61B17/88 ,  A61F2/28

CPC分类号： A61F2/38 ,  A61B5/055 ,  A61B5/4504 ,  A61B5/4585 ,  A61B17/68 ,  A61B17/8805 ,  A61B17/8811 ,  A61B17/8825 ,  A61B2017/00933 ,  A61F2/28 ,  A61F2/389 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/2892 ,  A61F2310/00023 ,  A61F2310/00131 ,  A61L24/02 ,  A61L27/12 ,  A61L27/50 ,  A61L2400/06 ,  A61L2430/02 ,  Y10S623/908

摘要： A method for treating arthritis of a joint includes identifying a bone lesion in a bone adjacent to the joint; and implanting in the bone a reinforcing member in or adjacent to the bone lesion. A kit for conducting the method includes: (a) at least one reinforcing member having a proximal face adapted to face the joint, a distal face adapted to face away from the joint, and a wedge-shaped edge adapted to pierce bone, wherein the at least one reinforcing member is planar and sterile; and (b) a container adapted to maintain the at least one reinforcing member sterile. Another kit includes: (a) a sterile fluid; (b) a syringe for injecting the fluid into a bone; (c) a curing agent adapted to cure the fluid to polymerize and/or cross-link; and (d) a container adapted to maintain the sterility of contents of the container.