公开(公告)号：US20240270781A1

公开(公告)日：2024-08-15

申请号：US18290641

申请日：2021-10-19

申请人： GUANGZHOU HANFANG PHARMACEUTICAL CO., LTD.

发明人： Wendong XU ,  Cheng YUAN ,  Shunzhi TANG ,  Juyan LIU ,  Hongfei CAI ,  Bai BAI ,  Jing LI ,  Yuping FU ,  Songtao LI ,  Wancai PENG ,  Yonghua LI ,  Yao LI ,  Jirong LI ,  Shaoheng WEI ,  Jiali LI

IPC分类号： C07H17/04

CPC分类号： C07H17/04

摘要： Provided in the present disclosure is a preparation method of paeoniflorin-6′-O-benzene sulfonate. The method uses crude paeoniflorin instead of paeoniflorin as a raw material, which more complies with actual requirements of an industrial production process of paeoniflorin-6′-O-benzene sulfonate, and uses an organometallic catalyst, an acid-binding agent and chemically active benzenesulfonyl chloride to react with paeoniflorin. Compared with the prior art, the method significantly increases the yield of crude paeoniflorin-6′-O-benzene sulfonate which is separated and purified by means of column chromatography and then refined to obtain paeoniflorin-6′-O-benzenesulfonate with a content of at least 98%, thereby realizing industrial production of the paeoniflorin-6′-O-benzene sulfonate.