公开(公告)号：US20080020382A1

公开(公告)日：2008-01-24

申请号：US11575859

申请日：2005-10-07

申请人： Gabor Szabo ,  Gyorgy Lustyik ,  Miklos Szabo

发明人： Gabor Szabo ,  Gyorgy Lustyik ,  Miklos Szabo

IPC分类号： G01N33/554 ,  C12Q1/68 ,  G01N33/569 ,  G01N33/53

CPC分类号： G01N33/554

摘要： The invention relates to biological microbeads, and in certain embodiments, to the use thereof in flow-cytometric applications. Biological microbeads are fixed cells that may be surface-modified with proteins or other molecules that have specific binding properties. These surface-bound proteins may bind to target compounds bearing fluorescent labels that facilitate detection by flow cytometry. Provided are compositions and methods for the use of biological microbeads as an inexpensive alternative to synthetic microbeads for in an extensive number of flow-cytometric applications, including quantitative PCR, detection of nucleases, detection of proteases, and immunoassays.

摘要翻译： 本发明涉及生物微珠，并且在某些实施方案中涉及其在流式细胞术应用中的用途。 生物微珠是可以用具有特异性结合特性的蛋白质或其他分子进行表面修饰的固定细胞。 这些表面结合的蛋白质可能与携带荧光标记物的靶化合物结合，便于通过流式细胞术检测。 提供的是使用生物微珠作为合成微珠的廉价替代物的组合物和方法，用于大量流式细胞术应用，包括定量PCR，核酸酶检测，蛋白酶检测和免疫测定。

公开(公告)号：US4617700A

公开(公告)日：1986-10-21

申请号：US583506

申请日：1984-02-24

申请人： Geza Batorfalvi ,  Tibor Lendvai ,  Antal Radai ,  Gaborne Pongrac ,  Miklos Szabo ,  Jeno Szilardi

发明人： Geza Batorfalvi ,  Tibor Lendvai ,  Antal Radai ,  Gaborne Pongrac ,  Miklos Szabo ,  Jeno Szilardi

IPC分类号： A22B5/04 ,  A22B3/00

CPC分类号： A22B5/04

摘要： A process for the hygienic extraction and separate collection of animal blood fit and unfit for consumption, comprises stunning the animals prior to stabbing and providing the animals with serial numbers suitable for identification of the carcass and the blood to be extracted. The spot of stabbing on the throat of the animals is disinfected and the animals are cyclically stepped into a stabbing position. The animal is stabbed in the stabbing position with a disinfected stabbing tool which is exchanged for each animal and is provided with a closed outlet a hose-fitted hollow knife. The hygenic blood is extracted through the stabbing tool into one of a plurality of rotating blood collecting tanks arranged on a turntable and moved into an extracting position. An anticoagulant is added to the blood by gravity feed and after filling, the tanks are advanced toward into a first draining position for blood fit for consumption. If all the numbered carcasses pertinent to the blood in the tank in the first drawing position are held impeccable from the point of view of animal healthy examination, a control body effects the draining the blood from the collecting tank into a system for blood fit for consumption. If not impeccable, the tank is advanced with the blood in it forward to a second draining position and drained into a system for blood unfit for consumption. The drained tanks are washed and disinfected and advanced into the extracting position.

摘要翻译： 卫生提取和分离收集动物血液并不适合消费的方法包括在刺入前对动物进行刺激，并为动物提供适合鉴定屠体和待提取血液的序列号。 在动物喉咙上刺伤的地方被消毒，动物周期性地进入刺痛的位置。 使用消毒的刺伤工具将动物刺入刺伤位置，该工具为每只动物进行交换，并且设有封闭的出口，软管安装的空心刀。 血液通过刺入工具被提取到设置在转台上并移动到提取位置的多个旋转血液收集池中的一个。 通过重力饲料将抗凝剂加入到血液中，并且在填充之后，容器前进到第一排水位置以供血液适合消费。 如果从动物健康检查的观点来看，与罐中的血液相关的所有与尸体相关的编号的尸体从动物健康检查的观点来看都是无可挑剔的，则控制体将从收集罐排出的血液进入用于血液适应的消耗系统 。 如果不是无可挑剔的，坦克前进，血液中的血液向前排到第二个排水位置，并排入不适合消费的血液系统。 排出的水箱经过洗涤和消毒，进入提取位置。

公开(公告)号：US4385714A

公开(公告)日：1983-05-31

申请号：US210151

申请日：1980-11-25

申请人： Miklos Szabo ,  Vilmos Weiperth

发明人： Miklos Szabo ,  Vilmos Weiperth

IPC分类号： B65D83/00 ,  B65D83/14 ,  B65D83/06 ,  B67B7/24 ,  B67D5/54

CPC分类号： B65D83/64 ,  B65D83/75 ,  B65D2583/005

摘要： The invention relates to an apparatus for and a method of spreading gaseous, liquid and powdered materials, that are applicable to pressing out creamy or foamy materials, too. According to the method a material to be spread is placed in a tank into the pressure vessel, overpressure is developed in the pressure vessel for spreading, whereby the tank moves towards the spreading nozzle and the spreading nozzle is communicated with the interior of the tank. The apparatus comprises a pressure vessel with its interior space divided into two sections, one of them contains the fuel tank ensuring the overpressure, the other one contains the material tank sealing airtightly the first section. The invention provides reliable spreading, not polluting the environment, the pressure vessel of the apparatus is not to be thrown away, and the tanks inside the vessel are replaceable.

摘要翻译： 本发明涉及一种用于扩散气态，液态和粉末状材料的设备和方法，其也适用于挤出奶油或泡沫材料。 根据该方法，将待扩散的材料放入罐中进入压力容器中，在压力容器中显影超压用于铺展，由此罐朝向扩展喷嘴移动，并且扩展喷嘴与罐的内部连通。 该装置包括压力容器，其内部空间分成两部分，其中一个包含确保过压的燃料箱，另一个容纳材料箱密封地密封第一部分。 本发明提供可靠的散布，不污染环境，不会将设备的压力容器扔掉，容器内的罐体可更换。

公开(公告)号：US20090209617A1

公开(公告)日：2009-08-20

申请号：US12282914

申请日：2007-03-13

申请人： Tibor Mezei ,  Gyula Simig ,  Eniko Molnar ,  Miklos Szabo ,  Gyula Lukacs ,  Marta Porcs-Makkay ,  Erika Szilagyi ,  Tibor Bako

发明人： Tibor Mezei ,  Gyula Simig ,  Eniko Molnar ,  Miklos Szabo ,  Gyula Lukacs ,  Marta Porcs-Makkay ,  Erika Szilagyi ,  Tibor Bako

IPC分类号： A61K31/381 ,  C07D333/20 ,  G01N30/02 ,  C07D333/16 ,  A61P25/24 ,  A61P25/22

CPC分类号： C07D333/20

摘要： The subject of the present invention is the provision of new salts of duloxetine of the Formula (I) with organic acids, process for their preparation and medicinal products containing thereof. The new salts are essentially free from the impurity of the Formula (II) and possess high purity and high stability. The new duloxetine salts are prepared by reacting duloxetine free base dissolved in an organic solvent with an approximately equimolar amount of an organic acid. Particularly advantageous crystalline salts are those formed with fumaric acid, citric acid or (−)-mandelic acid.

摘要翻译： 本发明的主题是提供式（I）的度洛西汀的新盐与有机酸，其制备方法和含有它们的药用产品。 新的盐基本上不含式（Ⅱ）的杂质，具有高纯度和高稳定性。 通过将溶解在有机溶剂中的度洛西汀游离碱与约等摩尔量的有机酸反应来制备新的度洛西汀盐。 特别有利的结晶盐是由富马酸，柠檬酸或（ - ） - 扁桃酸形成的盐。