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    Substituted pyrimidine compounds and uses thereof
    1.
    发明授权
    Substituted pyrimidine compounds and uses thereof 有权
    取代的嘧啶化合物及其用途

    公开(公告)号：US09567318B2

    公开(公告)日：2017-02-14

    申请号：US13391148

    申请日：2010-08-17

    申请人： Gabriela Chiosis ,  Tony Taldone ,  Anna Rodina ,  Pallav Patel ,  Yanlong Kang

    发明人： Gabriela Chiosis ,  Tony Taldone ,  Anna Rodina ,  Pallav Patel ,  Yanlong Kang

    IPC分类号： A61K31/496 ,  C07D403/14 ,  C07D495/04 ,  C07D403/12 ,  C07D239/38 ,  C07D239/47 ,  C07D239/56 ,  C07D239/60

    CPC分类号： A61K31/513 ,  A61K31/496 ,  A61K31/506 ,  A61K2121/00 ,  C07D239/38 ,  C07D239/47 ,  C07D239/56 ,  C07D239/60 ,  C07D403/12 ,  C07D495/04

    摘要： The present subject matter relates to a compound represented by the general formula (I) or (I′) or a pharmacologically acceptable salt thereof; pharmaceutical compositions containing at least one of these compounds; methods of making at least one of these compounds; methods of using at least one of these compounds for treating and/or preventing various cancers and/or proliferation disorders; methods of using at least one of these compounds for monitoring the effectiveness of an anticancer therapy against various cancers. In one embodiment, the subject matter relates to compounds that bind with a level of specificity to heat shock protein 70 (Hsp70). In another embodiment, the subject matter relates to compounds that bind with a level of specificity to inhibit both heat shock protein 70 (Hsp70) and heat shock cognate protein 70 (Hsc70).

    摘要翻译： 本发明涉及由通式（I）或（I'）表示的化合物或其药理学上可接受的盐; 含有这些化合物中的至少一种的药物组合物; 制备这些化合物中的至少一种的方法; 使用这些化合物中的至少一种治疗和/或预防各种癌症和/或增殖病症的方法; 使用这些化合物中的至少一种来监测针对各种癌症的抗癌疗法的有效性的方法。 在一个实施方案中，主题涉及与热休克蛋白70（Hsp70）的特异性水平结合的化合物。 在另一个实施方案中，主题涉及以特异性水平结合以抑制热休克蛋白70（Hsp70）和热休克同源蛋白70（Hsc70）的化合物。

    HEAT SHOCK PROTEIN BINDING COMPOUNDS, COMPOSITIONS, AND METHODS FOR MAKING AND USING SAME
    2.
    发明申请
    HEAT SHOCK PROTEIN BINDING COMPOUNDS, COMPOSITIONS, AND METHODS FOR MAKING AND USING SAME 有权
    热休克蛋白结合化合物，组合物及其制备和使用方法

    公开(公告)号：US20120252818A1

    公开(公告)日：2012-10-04

    申请号：US13391148

    申请日：2010-08-17

    申请人： Gabriela Chiosis ,  Tony Taldone ,  Anna Rodina ,  Pallav Patel ,  Yanlong Kang

    发明人： Gabriela Chiosis ,  Tony Taldone ,  Anna Rodina ,  Pallav Patel ,  Yanlong Kang

    IPC分类号： A61K31/496 ,  G01N27/62 ,  G06G7/58 ,  G01N21/76 ,  A61P35/00 ,  C07D495/04 ,  C12N9/99 ,  C07D403/14

    CPC分类号： A61K31/513 ,  A61K31/496 ,  A61K31/506 ,  A61K2121/00 ,  C07D239/38 ,  C07D239/47 ,  C07D239/56 ,  C07D239/60 ,  C07D403/12 ,  C07D495/04

    摘要： The present subject matter relates to a compound represented by the general formula (I) or (I′) or a pharmacologically acceptable salt thereof; pharmaceutical compositions containing at least one of these compounds; methods of making at least one of these compounds; methods of using at least one of these compounds for treating and/or preventing various cancers and/or proliferation disorders; methods of using at least one of these compounds for monitoring the effectiveness of an anticancer therapy against various cancers. In one embodiment, the subject matter relates to compounds that bind with a level of specificity to heat shock protein 70 (Hsp70). In another embodiment, the subject matter relates to compounds that bind with a level of specificity to inhibit both heat shock protein 70 (Hsp70) and heat shock cognate protein 70 (Hsc70).

    摘要翻译： 本发明涉及由通式（I）或（I'）表示的化合物或其药理学上可接受的盐; 含有这些化合物中的至少一种的药物组合物; 制备这些化合物中的至少一种的方法; 使用这些化合物中的至少一种治疗和/或预防各种癌症和/或增殖病症的方法; 使用这些化合物中的至少一种来监测针对各种癌症的抗癌疗法的有效性的方法。 在一个实施方案中，主题涉及结合热休克蛋白70（Hsp70）的特异性水平的化合物。 在另一个实施方案中，主题涉及以特异性水平结合以抑制热休克蛋白70（Hsp70）和热休克同源蛋白70（Hsc70）的化合物。