公开(公告)号：US20070031835A1

公开(公告)日：2007-02-08

申请号：US10551352

申请日：2004-03-29

申请人： Gail Risbridger ,  Donna Peehl ,  Sally Mellor ,  Emma Ball

发明人： Gail Risbridger ,  Donna Peehl ,  Sally Mellor ,  Emma Ball

IPC分类号： C12Q1/68 ,  G01N33/574

CPC分类号： G01N33/57434 ,  A61K38/00 ,  C07K16/26 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57484

摘要： The present invention relates generally to a method of diagnosing, predicting or monitoring the development or progress of advanced cancer and, in particular, to a method of diagnosing, predicting or monitoring the development of or progress of advanced prostate cancer in a mammal. The present invention contemplates a method for detecting advanced cancer, or predisposition to thereof, by screening for an increase in the level of inhibin expression in a mammal. The present invention further provides a method for diagnosing or monitoring conditions associated with or characterized by the onset of advanced cancer. Also provided are diagnostic agents useful for detecting inhibin or subunit thereof.

摘要翻译： 本发明一般涉及诊断，预测或监测晚期癌症的发展或进展的方法，特别涉及诊断，预测或监测哺乳动物晚期前列腺癌的发展或进展的方法。 本发明考虑了通过筛选哺乳动物抑制素表达水平的增加来检测晚期癌症或其倾向的方法。 本发明还提供了用于诊断或监测与晚期癌症发病相关或特征性的病症的方法。 还提供了可用于检测其抑制素或亚基的诊断剂。

公开(公告)号：US20090105343A1

公开(公告)日：2009-04-23

申请号：US10592251

申请日：2005-03-10

申请人： James Moray Campbell ,  Christopher Bunce ,  Lyndon Gommersall ,  Donna Peehl

发明人： James Moray Campbell ,  Christopher Bunce ,  Lyndon Gommersall ,  Donna Peehl

IPC分类号： A61K31/195 ,  C12N5/02 ,  A61K31/164

CPC分类号： A61K31/202 ,  A61K31/167 ,  A61K31/195 ,  A61K31/203 ,  A61K2300/00

摘要： The present invention relates to a novel cancer therapy, particularly, but not exclusively, to a prostate, bladder and breast cancer therapy and to Compositions and medicaments for use in said therapy. In one aspect there is provided a method of treating a patient afflicted with cancer comprising administering to the patient a therapeutically effective amount of a nuclear receptor ligand and an HDAC (histone deacetylases) inhibitor wherein said nuclear receptor ligand is not a ligand for the vitamin D receptor.

摘要翻译： 本发明涉及一种新的癌症治疗，特别地但不排他地涉及前列腺，膀胱和乳腺癌治疗以及用于所述治疗的组合物和药物。 在一个方面，提供了治疗患有癌症的患者的方法，包括向患者施用治疗有效量的核受体配体和HDAC（组蛋白脱乙酰酶）抑制剂，其中所述核受体配体不是维生素D的配体 受体。