公开(公告)号：US20060172347A1

公开(公告)日：2006-08-03

申请号：US10538431

申请日：2003-12-12

申请人： Sally Mellor ,  Gail Risbridger ,  Emma Ball ,  Hong Wang ,  Catriona McClean ,  John Pedersen ,  Anne O'Connor ,  Mark Cranfield ,  Nigel Groome

发明人： Sally Mellor ,  Gail Risbridger ,  Emma Ball ,  Hong Wang ,  Catriona McClean ,  John Pedersen ,  Anne O'Connor ,  Mark Cranfield ,  Nigel Groome

IPC分类号： G01N33/574

CPC分类号： G01N33/74 ,  C07K16/22 ,  G01N33/574

摘要： The present invention relates generally to a method of diagnosing, predicting or monitoring the development or progress of a condition characterised by modulation in the level of activin expression and, more particularly, a method of diagnosing, predicting or monitoring the development or progress of a condition characterised by modulation in the level of expression of activin bc subunit. The present invention still further provides methods for the therapeutic or prophylactic treatment of conditions characterised by aberrant, unwanted or otherwise inappropriate activin expression, for example, conditions characterised by over-expression or underexpression of activin and most particularly, conditions characterised by overexpression or underexpression of activin bc subunit. A further aspect of the present invention extends to agents for use in the methods of the present invention.

摘要翻译： 本发明一般涉及诊断，预测或监测以激活素表达水平调节为特征的疾病的发展或进展的方法，更具体地，涉及诊断，预测或监测病症发展或进展的方法 其特征在于激活素bc亚基的表达水平的调节。 本发明还进一步提供了用于治疗或预防性治疗以异常，不想要的或不适当的激活素表达为特征的病症的方法，例如以激活素过度表达或低表达为特征的病症，特别是以过表达或低表达为特征的病症 激活素bc亚基。 本发明的另一方面扩展到用于本发明方法的试剂。

公开(公告)号：US20080038729A1

公开(公告)日：2008-02-14

申请号：US11578711

申请日：2005-04-15

申请人： Gail Risbridger ,  Sally Mellor ,  Emma Ball ,  Hong Wang ,  John Pedersen ,  Catriona McLean

发明人： Gail Risbridger ,  Sally Mellor ,  Emma Ball ,  Hong Wang ,  John Pedersen ,  Catriona McLean

IPC分类号： C12Q1/68 ,  G01N33/574 ,  G01N33/68 ,  G01N33/74

CPC分类号： G01N33/57434 ,  C12Q1/6886 ,  C12Q2600/112 ,  G01N33/74 ,  G01N2333/475

摘要： The present invention relates generally to a method of diagnosing, predicting or monitoring the development or progress of a cancer and, in particular, to a method of diagnosing, predicting or monitoring the development of or progress of prostate cancer in a mammal. The present invention more specifically provides a method for delineating early stage and advanced stage cancers, or predispositions thereto, by screening for changes in the level of two or more of inhibin-α, activin-βA, activin-βB, activin-βC, activin-βD, activin-βE or follistatin expression in a mammal. The present invention further provides a method for diagnosing or monitoring conditions associated with or characterized by the onset of a cancer.

摘要翻译： 本发明一般涉及一种诊断，预测或监测癌症的发展或进展的方法，尤其涉及诊断，预测或监测哺乳动物前列腺癌发展或进展的方法。 本发明更具体地提供了通过筛选两种或更多种抑制素-α，激活素βA激活素水平的变化来描述早期阶段和晚期阶段癌症或其倾向的方法 β-激活素β1，活化素β-β，活化素β-β，活化素-βE，或活化素-β 哺乳动物 本发明还提供了用于诊断或监测与癌症发作相关或特征在于癌症发病的病症的方法。

公开(公告)号：US20070031835A1

公开(公告)日：2007-02-08

申请号：US10551352

申请日：2004-03-29

申请人： Gail Risbridger ,  Donna Peehl ,  Sally Mellor ,  Emma Ball

发明人： Gail Risbridger ,  Donna Peehl ,  Sally Mellor ,  Emma Ball

IPC分类号： C12Q1/68 ,  G01N33/574

CPC分类号： G01N33/57434 ,  A61K38/00 ,  C07K16/26 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57484

摘要： The present invention relates generally to a method of diagnosing, predicting or monitoring the development or progress of advanced cancer and, in particular, to a method of diagnosing, predicting or monitoring the development of or progress of advanced prostate cancer in a mammal. The present invention contemplates a method for detecting advanced cancer, or predisposition to thereof, by screening for an increase in the level of inhibin expression in a mammal. The present invention further provides a method for diagnosing or monitoring conditions associated with or characterized by the onset of advanced cancer. Also provided are diagnostic agents useful for detecting inhibin or subunit thereof.

摘要翻译： 本发明一般涉及诊断，预测或监测晚期癌症的发展或进展的方法，特别涉及诊断，预测或监测哺乳动物晚期前列腺癌的发展或进展的方法。 本发明考虑了通过筛选哺乳动物抑制素表达水平的增加来检测晚期癌症或其倾向的方法。 本发明还提供了用于诊断或监测与晚期癌症发病相关或特征性的病症的方法。 还提供了可用于检测其抑制素或亚基的诊断剂。

公开(公告)号：US20050266519A1

公开(公告)日：2005-12-01

申请号：US10318283

申请日：2002-12-12

申请人： Sally Mellor ,  Gail Risbridger ,  Nigel Groome ,  Mark Cranfield ,  Emma Ball ,  Anne O'Connor ,  David Phillips ,  Jacqui Schmitt ,  Jean Ethier

发明人： Sally Mellor ,  Gail Risbridger ,  Nigel Groome ,  Mark Cranfield ,  Emma Ball ,  Anne O'Connor ,  David Phillips ,  Jacqui Schmitt ,  Jean Ethier

IPC分类号： A61K38/17 ,  C07K14/575 ,  C07K16/22 ,  C12N5/06 ,  C12N15/85 ,  C12P21/02

CPC分类号： C07K16/22 ,  A61K38/1709 ,  C07K14/575 ,  G01N2333/575

摘要： Methods and compositions for modulating activin dimer formation, such as the formation of activin dimers formed by the dimerisation of activin subunits βA, βB, βC, βD, or βE, or combinations thereof, are provided. The invention also relates to methods and compositions for detecting an activin monomer or dimer using, for example, an antibody. Methods and compositions for diagnosing and/or prognosing, preventing or treating conditions and/or diseases associated with activin dimer formation, such as prostate cancer, are disclosed.

摘要翻译： 用于调节激活素二聚体形成的方法和组合物，例如通过激活素亚基β2，βB，C 2 C的二聚形成的激活素二聚体的形成， 提供了SUB，β，β或βE或其组合。 本发明还涉及使用例如抗体检测激活素单体或二聚体的方法和组合物。 公开了用于诊断和/或预后，预防或治疗与激活素二聚体形成相关的病症和/或疾病如前列腺癌的方法和组合物。