公开(公告)号：US20040242502A1

公开(公告)日：2004-12-02

申请号：US10820036

申请日：2004-04-08

申请人： Galenica Pharmaceuticals, Inc.

发明人： Dante J. Marciani

IPC分类号： A61K031/704 ,  C07H015/24 ,  C07J017/00

CPC分类号： C07J17/00 ,  C07H15/24 ,  C07H15/256

摘要： The present invention discloses novel saponin derivatives for use with nucleic acids that induce an immune response when administered to animals and humans. The novel saponin derivatives disclosed comprise (a) a saponin aglycone core, wherein the aglycone core is covalently linked to one or more oligosaccharide chains; (b) a positively charged cationic chain, and optionally (c) a naturally occurring or synthetic lipophilic chain. Pharmaceutical and veterinary compositions comprising one or more of the novel saponin derivatives and saponin derivative/polynucleotide complexes are also disclosed. Disclosed as well are methods of using the novel saponin derivatives to deliver a polynucleotide molecule to cells of an animal, to stimulate or generate an immune response in an animal, and to generate a detectable immune response in an animal.

摘要翻译： 本发明公开了用于当被给予动物和人时诱导免疫应答的核酸的新型皂苷衍生物。 所公开的新型皂苷衍生物包含（a）皂苷苷元糖苷配基核心，其中糖苷配基核共价连接至一个或多个寡糖链; （b）带正电的阳离子链，和任选地（c）天然存在的或合成的亲脂链。 还公开了包含一种或多种新型皂苷衍生物和皂苷衍生物/多核苷酸复合物的药物和兽药组合物。 还公开了使用新型皂苷衍生物将多核苷酸分子递送至动物细胞，刺激或产生动物免疫应答并在动物中产生可检测的免疫应答的方法。

公开(公告)号：US20040220142A1

公开(公告)日：2004-11-04

申请号：US10859577

申请日：2004-06-03

申请人： Galenica Pharmaceuticals, Inc.

发明人： Dante J. Marciani

IPC分类号： A61K031/715 ,  C07H015/04

CPC分类号： C08B37/003 ,  A61K47/61

摘要： The present invention relates to polysaccharide conjugates that comprise: a polysaccharide that binds to surface-receptors present on Antigen Presenting Cells, conjugated to one or more compounds having stable carbonyl groups covalently attached, either directly or via a bifunctional linker. The conjugates are useful as immuno-stimulants and adjuvants.

公开(公告)号：US20020150585A1

公开(公告)日：2002-10-17

申请号：US10114465

申请日：2002-04-03

申请人： Galenica Pharmaceuticals, Inc.

发明人： Dante J. Marciani

IPC分类号： A61K039/00 ,  A61K031/739 ,  A61K031/715

CPC分类号： C08B37/003 ,  A61K47/61

摘要： The present invention relates to polysaccharide conjugates that comprise: a polysaccharide that binds to surface-receptors present on Antigen Presenting Cells, conjugated to one or more compounds having stable carbonyl groups covalently attached, either directly or via a bifunctional linker. The conjugates are useful as immuno-stimulants and adjuvants.

摘要翻译： 本发明涉及多糖缀合物，其包含：直接或通过双功能连接体结合存在于存在于抗原呈递细胞上的表面受体的多糖，缀合至一个或多个具有共价连接的稳定羰基的化合物。 缀合物可用作免疫兴奋剂和佐剂。