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    Use of lectins to promote oligomerization of glycoproteins and antigenic molecules
    1.
    发明申请
    Use of lectins to promote oligomerization of glycoproteins and antigenic molecules 审中-公开
    使用凝集素促进糖蛋白和抗原分子的低聚

    公开(公告)号：US20040258705A1

    公开(公告)日：2004-12-23

    申请号：US10789220

    申请日：2004-02-27

    申请人： Antigenics Inc.

    发明人： James R. Zabrecky ,  Stephen A. Monks

    IPC分类号： A61K039/385 ,  A61K039/00

    CPC分类号： A61K39/0011 ,  A61K2039/55511 ,  A61K2039/55516 ,  A61K2300/00

    摘要： The present invention relates to using lectin or lectin-like molecules to promote oligomerization of a glycoprotein or an immunologically and/or biologically active complex comprising glycoproteins. In particular, the invention provides compositions of a molecular complex comprising lectin molecules and immunologically and/or biologically active molecules. Methods of making such molecular complexes and methods of use of the compositions comprising such molecular complexes for the prevention and treatment of diseases, particularly cancer and infectious diseases, and for eliciting an immune response in a subject, are also provided.

    摘要翻译： 本发明涉及使用凝集素或凝集素样分子来促进包含糖蛋白的糖蛋白或免疫学和/或生物活性复合物的低聚。 特别地，本发明提供了包含凝集素分子和免疫学和/或生物活性分子的分子复合物的组合物。 还提供了制备这种分子复合物的方法和包含这种分子复合物的组合物用于预防和治疗疾病，特别是癌症和感染性疾病以及在受试者中引发免疫应答的方法。

    Antigens of and antibodies to translocated molecules of microorganisms and uses thereof
    4.
    发明申请
    Antigens of and antibodies to translocated molecules of microorganisms and uses thereof 审中-公开
    易位微生物分子的抗原和抗体及其用途

    公开(公告)号：US20040241689A1

    公开(公告)日：2004-12-02

    申请号：US10485002

    申请日：2004-06-28

    发明人： Joel B. Baseman ,  Thirumalai R. Kannan ,  Rene Alvarez

    IPC分类号： C12Q001/68 ,  A61K039/00 ,  A61K039/38

    CPC分类号： C12Y102/01051 ,  A61K38/00 ,  C07K14/47 ,  C12N9/0008 ,  C12Y102/05001

    摘要： This application describes intracellular, cytoplasmic molecules that are translocated to the surface of a microorganism and participate in binding the microorganism to the surface of a host cell. Examples of such translocated molecules include glycerahdehyde 3-phosphate dehydrogenase, pyruvate dehydrogenase, and elongation factor-Tu. Regions of translocated molecules important for binding, as well as molecules which disrupt binding, are described. Antibodies directed to translocated molecules are also described.

    摘要翻译： 本申请描述了易位于微生物表面并参与将微生物结合到宿主细胞表面的细胞内的细胞质分子。 这种易位分子的实例包括甘油醛3-磷酸脱氢酶，丙酮酸脱氢酶和延伸因子-Tu。 描述了对于结合重要的易位分子的区域以及破坏结合的分子。 还描述了针对易位分子的抗体。

    Novel compositions and uses therefor
    6.
    发明申请
    Novel compositions and uses therefor 有权
    新型组合物及其用途

    公开(公告)号：US20040241177A1

    公开(公告)日：2004-12-02

    申请号：US10475203

    申请日：2004-05-26

    发明人： Ian Hector Frazer

    IPC分类号： A61K048/00 ,  A61K039/00

    CPC分类号： A61K39/12 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61K2039/5158 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/005 ,  C07K19/00 ,  C12N7/00 ,  C12N15/67 ,  C12N2710/20022 ,  C12N2710/20034 ,  Y02A50/467

    摘要： The invention is directed to the use of (i) a first antigen corresponding to a target antigen of interest, together with (ii) a second antigen, corresponding to a modified form of the target antigen, whose rate of intracellular proteolytic degradation is increased, enhanced or otherwise elevated relative to the first antigen, in compositions and methods for inducing both humoral and cellular immunity in an individual. The ability to provide compositions, which are capable of inducing both host-protective antibody and cell-mediated immune responses, facilitates the generation of immunogenic compositions capable of combating, inter alia, conditions that have long latency periods and, therefore, benefit from the dual approach of prophylaxis and therapy in one delivery.

    摘要翻译： 本发明涉及（i）对应于感兴趣的靶抗原的第一抗原与（ii）对应于细胞内蛋白水解降解速率增加的靶抗原修饰形式的第二抗原的用途， 在个体中诱导体液和细胞免疫的组合物和方法中相对于第一抗原增强或以其它方式升高。 提供能够诱导宿主保护性抗体和细胞介导的免疫应答的组合物的能力有助于产生免疫原性组合物，特别是能够抵抗具有长潜伏期并因此受益于双重作用的病症 一次性预防和治疗的方法。

    Nucleic acid vaccine compositions having a mammalian cd80/cd86 gene promoter driving antigen expression
    7.
    发明申请
    Nucleic acid vaccine compositions having a mammalian cd80/cd86 gene promoter driving antigen expression 审中-公开
    具有驱动抗原表达的哺乳动物cd80 / cd86基因启动子的核酸疫苗组合物

    公开(公告)号：US20040234539A1

    公开(公告)日：2004-11-25

    申请号：US10747198

    申请日：2003-12-30

    申请人： Powderject Research Limited

    发明人： Scott Umlauf

    IPC分类号： A61K048/00 ,  A61K039/00

    CPC分类号： A61K39/00 ,  A61K38/177 ,  A61K38/18 ,  A61K39/12 ,  A61K39/292 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55522 ,  C07K14/005 ,  C12N15/895 ,  C12N2730/10122 ,  C12N2730/10134 ,  A61K2300/00

    摘要： Polynucleotides encoding at least one immunizing antigen whose expression is controlled by a promoter derived from a gene encoding a co-stimulatory molecule are provided. The polynucleotides may also encode adjuvants. Compositions comprising at least one immunizing agent and at least one cytokine that enhance dendritic cell stimulation and/or survival are also provided. Methods for eliciting an immune response against the immunizing agent are also provided. The method includes the steps of administering the polynucleotides and, optionally, co-administering an adjuvant.

    摘要翻译： 提供编码至少一种免疫抗原的多核苷酸，其表达由源自编码共刺激分子的基因的启动子控制。 多核苷酸还可以编码佐剂。 还提供了包含至少一种免疫剂和至少一种增强树突状细胞刺激和/或存活的细胞因子的组合物。 还提供了针对免疫剂引起免疫应答的方法。 该方法包括施用多核苷酸和任选地共同施用佐剂的步骤。

    Carcinoma-related peptides
    8.
    发明申请
    Carcinoma-related peptides 审中-公开
    癌相关肽

    公开(公告)号：US20040234537A1

    公开(公告)日：2004-11-25

    申请号：US10482985

    申请日：2004-05-27

    发明人： Lydie Bougueleret ,  Anne Niknejad

    IPC分类号： G01N033/574 ,  C07H021/04 ,  A61K039/00 ,  C07K014/47

    CPC分类号： C07K14/47 ,  C07K14/4748 ,  C07K16/30 ,  C07K2317/34 ,  G01N33/574

    摘要： The present invention is directed to methods and compositions for detecting the presence of or for measuring the levels of one or more carcinoma-related peptides in biological samples, especially human tissues. The invention further includes methods and kits for monitoring the levels of carcinoma-related peptides in an individual. 1

    摘要翻译： 本发明涉及用于检测生物样品，特别是人体组织中一种或多种癌相关肽的存在或用于测量水平的方法和组合物。 本发明还包括用于监测个体中癌相关肽水平的方法和试剂盒。

    Methods and compositions for therapeutic intervention in infectious disease
    9.
    发明申请
    Methods and compositions for therapeutic intervention in infectious disease 审中-公开
    传染病治疗干预的方法和组合物

    公开(公告)号：US20040219159A1

    公开(公告)日：2004-11-04

    申请号：US10807963

    申请日：2004-03-24

    发明人： Graham Stewart ,  Peadar O'Gaora ,  Douglas Young

    IPC分类号： A61K039/00 ,  A61K039/38 ,  A61K039/04

    CPC分类号： C07K14/35 ,  A61K39/04 ,  A61K2039/52

    摘要： Methods and compositions for the treatment and prevention of infectious diseases are provided. In particular, efficient vaccines comprising genetically modified pathogens are provided. The vaccines generally comprise mycobacterial mutants having modified protein production capabilities. In one embodiment, the mutants overexpress heat shock protein. In a specific embodiment, the mycobacterial mutant overexpresses heat shock proteins 60 and/or 70. Also provided are modified BCG vaccines capable of overexpressing heat shock proteins 60 and/or 70.

    摘要翻译： 提供了治疗和预防感染性疾病的方法和组合物。 特别地，提供了包含转基因病原体的高效疫苗。 疫苗通常包含具有改变的蛋白质生产能力的分枝杆菌突变体。 在一个实施方案中，突变体过表达热休克蛋白。 在具体实施方案中，分枝杆菌突变体过表达热休克蛋白60和/或70.还提供能够过表达热休克蛋白60和/或70的经修饰的BCG疫苗。

    Vaccination against prion diseases
    10.
    发明申请
    Vaccination against prion diseases 审中-公开
    疫苗接种朊病毒疾病

    公开(公告)号：US20040208919A1

    公开(公告)日：2004-10-21

    申请号：US10461864

    申请日：2003-06-13

    发明人： Yves C. Nicolau ,  Ernest Kapetanovic

    IPC分类号： A61K039/00 ,  A61K009/127

    CPC分类号： A61K39/0007

    摘要： Compositions and methods for the treatment or prevention of neurodegenerative diseases caused by the accumulation of prions. Therapeutic vaccines, antisera and molecular constructs are described. The vaccine is composed of an antigen, such as a prion peptide fragment or epitope that is preferably provided in a liposomal bilayer. In a preferred embodiment, the antigen is a modified amyloid peptide, preferably a palmitoylated PrPc106-126 peptide. Preferably, the antigen is administered in a liposomal bilayer. When administered to an animal, the vaccine elicits a local or systemic, immunogen-specific immune response against amyloid proteins, peptides or fragments, and prevents, stops or hinders amyloid deposition caused by prions.

    摘要翻译： 用于治疗或预防由朊病毒积聚引起的神经变性疾病的组合物和方法。 描述了治疗性疫苗，抗血清和分子构建体。 疫苗由抗原，例如优选提供在脂质体双层中的朊病毒肽片段或表位组成。 在优选的实施方案中，抗原是修饰的淀粉样蛋白肽，优选棕榈酰化的PrP 106-126肽。 优选地，抗原以脂质体双层施用。 当给动物施用时，疫苗引发针对淀粉样蛋白，肽或片段的局部或系统的免疫原特异性免疫应答，并且防止，阻止或阻碍由朊病毒引起的淀粉样蛋白沉积。