公开(公告)号：US20220193408A1

公开(公告)日：2022-06-23

申请号：US17690974

申请日：2022-03-09

Applicant: Galvani Bioelectronics Limited

Inventor： Brian Marc PEPIN ,  Brian OTIS

IPC: A61N1/36 ,  H02J50/80 ,  H02J50/10 ,  H02J50/20 ,  H02J50/40 ,  A61N1/05 ,  A61N1/372 ,  A61N1/378 ,  H02J7/02 ,  H02J7/34

Abstract: Systems and methods are provided for stimulating one or more nerves with an implantable device. The implantable device may comprise an antenna circuit including a loop antenna and a control circuit including a rectifying diode for rectifying an alternating voltage induced in the antenna circuit by an external electromagnetic field. The implantable device may also include a chargeable storage element for storing energy from the rectified voltage without using a battery. The device may also include an electrode array containing a set of electrodes for emitting an electric field using the stored energy in response to a control signal received from the control circuit. The components of the device may be affixed onto a soft polymer substrate including a linkable peripheral tab on at least two edges of a substantially rectangular body section of the substrate for forming a cuff about the one or more nerves to be stimulated.

公开(公告)号：US20200016404A1

公开(公告)日：2020-01-16

申请号：US16485673

申请日：2018-02-12

Applicant: Galvani Bioelectronics Limited

Inventor： Brian Marc PEPIN ,  Shiv SABESAN

IPC: A61N1/36

Abstract: This disclosure relates to implantable neuromodulation systems and methods, and in particular to systems and methods for sensing blood-based parameter changes triggered by neural stimulation and subsequently optimizing the stimulation parameters based on feedback from the sensed blood-based parameter changes. Embodiments are directed to a method that includes delivering neural stimulation to a nerve or artery/nerve plexus based on a first set of stimulation parameters, monitoring a response to the neural stimulation that includes monitoring responses of the nerve or artery/nerve plexus and blood-based parameters of the artery, modifying the first set of the stimulation parameters based on the blood-based parameters to create a second set of stimulation parameters, and delivering the neural stimulation based on the second set of the stimulation parameters.