公开(公告)号：US20220023635A1

公开(公告)日：2022-01-27

申请号：US17450308

申请日：2021-10-08

Applicant: Galvani Bioelectronics Limited

Inventor： Brian PEPIN ,  Shiv SABESAN

IPC: A61N1/36 ,  A61N1/05

Abstract: This disclosure relates to implantable neuromodulation systems and methods, and in particular to systems and methods for sensing blood-based parameter changes triggered by neural stimulation and subsequently optimizing the stimulation parameters based on feedback from the sensed blood-based parameter changes. Embodiments are directed to a method that includes delivering neural stimulation to a nerve or artery/nerve plexus based on a first set of stimulation parameters, monitoring a response to the neural stimulation that includes monitoring responses of the nerve or artery/nerve plexus and blood-based parameters of the artery, modifying the first set of the stimulation parameters based on the blood-based parameters to create a second set of stimulation parameters, and delivering the neural stimulation based on the second set of the stimulation parameters.

公开(公告)号：US20200016404A1

公开(公告)日：2020-01-16

申请号：US16485673

申请日：2018-02-12

Applicant: Galvani Bioelectronics Limited

Inventor： Brian Marc PEPIN ,  Shiv SABESAN

IPC: A61N1/36

Abstract: This disclosure relates to implantable neuromodulation systems and methods, and in particular to systems and methods for sensing blood-based parameter changes triggered by neural stimulation and subsequently optimizing the stimulation parameters based on feedback from the sensed blood-based parameter changes. Embodiments are directed to a method that includes delivering neural stimulation to a nerve or artery/nerve plexus based on a first set of stimulation parameters, monitoring a response to the neural stimulation that includes monitoring responses of the nerve or artery/nerve plexus and blood-based parameters of the artery, modifying the first set of the stimulation parameters based on the blood-based parameters to create a second set of stimulation parameters, and delivering the neural stimulation based on the second set of the stimulation parameters.