公开(公告)号：US11944812B2

公开(公告)日：2024-04-02

申请号：US17739897

申请日：2022-05-09

Applicant: GALVANI BIOELECTRONICS LIMITED

Inventor： Faisal Zaidi ,  Sebastien Ouchouche

IPC: A61N1/05 ,  A61N1/36

CPC classification number: A61N1/0556

Abstract: An extravascular neural interface includes a device containing electrodes for neurostimulation of a vessel. The devices are housed in flexible substrates forming two flaps, an inner flap having a spinal portion for routing leads/conductors into the device for connection to the electrodes and an outer flap that overlaps the inner flap. The inner flap supports and positions the electrodes to be inward facing, i.e., extravascular designs. The electrodes may be circular or elliptical and include a plurality of wings for securing the electrodes within a flap.

公开(公告)号：US12280253B2

公开(公告)日：2025-04-22

申请号：US17248735

申请日：2021-02-05

Applicant: Galvani Bioelectronics Limited

Inventor： Faisal Zaidi ,  Sabastien Ouchouche ,  Paul Matteucci

IPC: A61N1/05 ,  A61K9/00 ,  A61K31/56 ,  A61N1/36 ,  A61N1/375

Abstract: An extravascular or intravascular neural interface is disclosed comprising three C-ring portions, with at least two including an electrode, an electrode pair or an electrode array. The portions are formed of a flexible material that is configured to enable the portions to self-size to fit around or against a surface of a target vessel when the neural interface is released at a position along the target vessel. A spinal portion configured to house electrical conductors for the electrodes is connected to one or more portions. The portions may be spaced sufficient apart to permit radial expansion and contraction of a target vessel around or within which the neural interface is placed, to reduce never compression, open trench low-pressure unrestricted blood-flow, and to enhance fluid exchange with the target vessel. The portions may be arranged in a low helix angle forming at least two full turns.

公开(公告)号：US20220409888A1

公开(公告)日：2022-12-29

申请号：US17780195

申请日：2020-11-27

Applicant: Galvani Bioelectronics Limited

Inventor： Sebastien Ouchouche ,  David Karl Lee Peterson ,  Eric Irwin ,  Robert W. Coatney ,  Benjamin Yaffe ,  Morten Hansen ,  Faisal Zaidi ,  Thomas Burge ,  Pey-Jiun Ko ,  Cindy Au ,  Paul Matteucci ,  Mark Gregory Palmer ,  Gerald Edwin Hunsberger

IPC: A61N1/05

Abstract: In embodiments a neural interface comprising at least one C-ring portion can be used to apply a pressure in a range of 0 mmHg to 30 mmHg to a target tissue arranged within the C-ring portion and comprising at least one electrode arranged on the at least one C-ring portion.

公开(公告)号：US11357976B2

公开(公告)日：2022-06-14

申请号：US16634632

申请日：2018-07-23

Applicant: GALVANI BIOELECTRONICS LIMITED

Inventor： Faisal Zaidi ,  Sebastien Ouchouche

IPC: A61N1/05 ,  A61N1/36

Abstract: An extravascular neural interface is disclosed including a device containing electrodes for neurostimulation of a vessel. The devices are housed in flexible substrates forming two flaps, an inner flap having a spinal portion for routing leads/conductors into the device for connection to the electrodes and an outer flap that overlaps the inner flap. The inner flap supports and positions the electrodes to be inward facing, i.e., extravascular designs. The electrodes may be circular or elliptical and include a plurality of wings for securing the electrodes within a flap.

公开(公告)号：US11559692B2

公开(公告)日：2023-01-24

申请号：US16634620

申请日：2018-07-23

Applicant: GALVANI BIOELECTRONICS LIMITED

Inventor： Faisal Zaidi ,  Sebastien Ouchouche

IPC: A61N1/05 ,  A61N1/372 ,  A61K31/56 ,  A61N1/375

Abstract: An extravascular neural interface is disclosed containing electrodes for neurostimulation of the vessel. The devices are housed in flexible substrates, each substrate having a spinal portion for routing leads/conductors into the device for connection to the electrodes. Extending from opposite sides of the spinal portion is a self-sizing inner flap that supports and positions the electrodes to be inward facing, i.e., extravascular designs, and one more rigid outer flap. The electrodes may be flexible multifilar coil electrodes.

公开(公告)号：US10946189B2

公开(公告)日：2021-03-16

申请号：US16619396

申请日：2018-07-23

Applicant: Galvani Bioelectronics Limited

Inventor： Faisal Zaidi ,  Sabastien Ouchouche ,  Paul Matteucci, Jr.

IPC: A61N1/05 ,  A61K9/00 ,  A61K31/56 ,  A61N1/36 ,  A61N1/375

Abstract: An extravascular or intravascular neural interface is disclosed and can include three C-ring portions, with at least two including an electrode, an electrode pair or an electrode array. The portions are formed of a flexible material that is configured to enable the portions to self-size to fit around or against a surface of a target vessel when the neural interface is released at a position along the target vessel. A spinal portion configured to house electrical conductors for the electrodes is connected to one or more portions. The portions may be spaced sufficient apart to permit radial expansion and contraction of a target vessel around or within which the neural interface is placed, to reduce nerve compression, open trench low-pressure unrestricted blood-flow, and to enhance fluid exchange with the target vessel. The portions may be arranged in a low helix angle forming at least two full turns.