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公开(公告)号:US20230018108A1
公开(公告)日:2023-01-19
申请号:US17893924
申请日:2022-08-23
Applicant: Galvani Bioelectronics Limited
Inventor: Gerald Edwin Hunsberger , Arun Sridhar
Abstract: Modulation of neural activity of a ganglion, by applying a signal to a sympathetic nerve adjacent to the ganglion, results in preferential reduction of sympathetic signals to an effector, thereby providing ways of treating and preventing conditions associated with exacerbated sympatho-excitation.
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公开(公告)号:US20220296886A1
公开(公告)日:2022-09-22
申请号:US17619572
申请日:2020-06-17
Applicant: Galvani Bioelectronics Limited
Inventor: Rizwan Bashirullah , Gerald Edwin Hunsberger
Abstract: A neuromodulation device for measuring an evoked response comprising a first electrode; a second electrode, wherein the first and second electrodes are alternately configured as a stimulation electrode; a sensing electrode for sensing an evoked response to a stimulus pulse; and a controller configured to measure an evoked response at the sensing electrode after a stimulus pulse at a first stimulation electrode configuration and after a stimulus pulse at a second alternate stimulation electrode configuration, and to add said pair of measurements.
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公开(公告)号:US20250099762A1
公开(公告)日:2025-03-27
申请号:US18924183
申请日:2024-10-23
Applicant: Galvani Bioelectronics Limited
Inventor: Gerald Edwin Hunsberger , Arun Sridhar
Abstract: Modulation of neural activity of a ganglion, by applying a signal to a sympathetic nerve adjacent to the ganglion, results in preferential reduction of sympathetic signals to an effector, thereby providing ways of treating and preventing conditions associated with exacerbated sympatho-excitation.
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4.
公开(公告)号:US11623098B2
公开(公告)日:2023-04-11
申请号:US15733223
申请日:2018-12-11
Applicant: Galvani Bioelectronics Limited
Inventor: Gerald Edwin Hunsberger
Abstract: There is provided a neural interface device for unidirectional stimulation of a nerve including at least one A-type nerve fiber or at least one at least partially myelinated nerve fiber. The device includes an electrode arrangement for placing on or around the nerve. The electrode arrangement includes a first electrode configured to be positively charged and a second electrode configured to be negatively charged, where the surface area of the second electrode is larger than the surface area of first electrode.
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公开(公告)号:US11672972B2
公开(公告)日:2023-06-13
申请号:US15733276
申请日:2018-12-11
Applicant: Galvani Bioelectronics Limited , UCL Business PLC
Inventor: Rizwan Bashirullah , Gerald Edwin Hunsberger , Matteo Donega , Daniel Chew , David Holder , Kirill Aristovich
CPC classification number: A61N1/0556 , A61N1/36053 , A61N1/36182
Abstract: A nerve interface device including at least one cuff portion having an assembled position in which the cuff portion forms at least part of a passageway for receiving a nerve along a longitudinal axis passing through the passageway; and first and second rings of electrodes mounted on the at least one cuff portion, each ring of electrodes including a plurality of electrodes. Each electrode in the first ring has a corresponding longitudinally-aligned electrode in the second ring so as to form a plurality of pairs of electrodes spaced apart from each other along the longitudinal axis. The plurality of pairs of electrodes includes at least a first pair of electrodes, the first pair of electrodes mounted on the at least one cuff portion. The at least one cuff portion includes an asymmetric configuration about a central axis perpendicular to the longitudinal cuff axis.
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6.
公开(公告)号:US20230010306A1
公开(公告)日:2023-01-12
申请号:US17785374
申请日:2020-12-15
Applicant: Galvani Bioelectronics Limited
Inventor: Rizwan Bashirullah , Gerald Edwin Hunsberger
Abstract: A stent for intravascular stimulation comprises a scaffold comprising first and second scaffold structures, each scaffold structure comprising at least one substantially annular portion. The stent further comprises one or more anodal electrodes formed from or electrically coupled to at least a substantially annular portion of the first scaffold structure and one or more cathodal electrodes electrically formed from or coupled to at least a substantially annular portion of the second scaffold structure. The stent further comprises an anodal lead electrically coupled to the first scaffold structure to form a conductive path from the one or more anodal electrodes to a generator and a cathodal lead electrically coupled to the second scaffold structure to form a conductive path from the one or more cathodal electrodes to the generator. The stent further comprises a sleeve of insulating material, wherein the scaffold structures are attached to or formed on the sleeve of insulating material and are separated from each other by a distance such that the first and second scaffold structures are electrically insulated from each other.
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公开(公告)号:US20220409888A1
公开(公告)日:2022-12-29
申请号:US17780195
申请日:2020-11-27
Applicant: Galvani Bioelectronics Limited
Inventor: Sebastien Ouchouche , David Karl Lee Peterson , Eric Irwin , Robert W. Coatney , Benjamin Yaffe , Morten Hansen , Faisal Zaidi , Thomas Burge , Pey-Jiun Ko , Cindy Au , Paul Matteucci , Mark Gregory Palmer , Gerald Edwin Hunsberger
IPC: A61N1/05
Abstract: In embodiments a neural interface comprising at least one C-ring portion can be used to apply a pressure in a range of 0 mmHg to 30 mmHg to a target tissue arranged within the C-ring portion and comprising at least one electrode arranged on the at least one C-ring portion.
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公开(公告)号:US12157007B2
公开(公告)日:2024-12-03
申请号:US17893924
申请日:2022-08-23
Applicant: Galvani Bioelectronics Limited
Inventor: Gerald Edwin Hunsberger , Arun Sridhar
Abstract: Modulation of neural activity of a ganglion, by applying a signal to a sympathetic nerve adjacent to the ganglion, results in preferential reduction of sympathetic signals to an effector, thereby providing ways of treating and preventing conditions associated with exacerbated sympatho-excitation.
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公开(公告)号:US11464976B2
公开(公告)日:2022-10-11
申请号:US16771441
申请日:2018-12-11
Applicant: Galvani Bioelectronics Limited
Inventor: Gerald Edwin Hunsberger , Arun Sridhar
Abstract: Modulation of neural activity of a ganglion, by applying a signal to a sympathetic nerve adjacent to the ganglion, results in preferential reduction of sympathetic signals to an effector, thereby providing ways of treating and preventing conditions associated with exacerbated sympatho-excitation.
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