公开(公告)号：US07396524B2

公开(公告)日：2008-07-08

申请号：US11194983

申请日：2005-08-02

Applicant: Gan-Xin Yan

Inventor： Gan-Xin Yan

IPC: A61K49/00

CPC classification number: G01N33/5088 ,  G01N33/6872 ,  G01N2500/04 ,  G01N2800/326

Abstract: Methods for screening compounds for their potential to induce or inhibit a cardiac arrhythmia are disclosed. The methods comprise determining the ratio of the time constant (τ) of ICa,L recovery in tissue expressing the L-type calcium channel or any subunit or combination thereof of the L-type calcium channel treated with a test compound to the ventricular repolarization time of cardiac tissue treated with a test compound. The methods further comprise determining an arrhythmic risk score for a specified dose of a test compound.

Abstract translation: 公开了筛选化合物诱导或抑制心律不齐的潜力的方法。 所述方法包括确定表达L型钙通道的组织中的ITA，L +回收的时间常数（τ）与其治疗的L型钙通道的任何亚基或其组合的比率 使用测试化合物治疗的心脏组织的心室复极化时间的测试化合物。 所述方法还包括确定特定剂量的测试化合物的心律失常风险评分。

公开(公告)号：US20070031817A1

公开(公告)日：2007-02-08

申请号：US11194983

申请日：2005-08-02

Applicant: Gan-Xin Yan

Inventor： Gan-Xin Yan

IPC: C12Q1/00

CPC classification number: G01N33/5088 ,  G01N33/6872 ,  G01N2500/04 ,  G01N2800/326

Abstract: Methods for screening compounds for their potential to induce or inhibit a cardiac arrhythmia are disclosed. The methods comprise determining the ratio of the time constant (τ) of ICa,L recovery in tissue expressing the L-type calcium channel or any subunit or combination thereof of the L-type calcium channel treated with a test compound to the ventricular repolarization time of cardiac tissue treated with a test compound. The methods further comprise determining an arrhythmic risk score for a specified dose of a test compound.

Abstract translation: 公开了筛选化合物诱导或抑制心律不齐的潜力的方法。 所述方法包括确定表达L型钙通道的组织中的ITA，L +回收的时间常数（τ）与其治疗的L型钙通道的任何亚基或其组合的比率 使用测试化合物治疗的心脏组织的心室复极化时间的测试化合物。 所述方法还包括确定特定剂量的测试化合物的心律失常风险评分。