公开(公告)号：US20190057183A1

公开(公告)日：2019-02-21

申请号：US16079664

申请日：2017-03-14

申请人： Gang Fang ,  Wen Wang ,  Vipin Kumar ,  Chad L. Myers

发明人： Gang Fang ,  Wen Wang ,  Vipin Kumar ,  Chad L. Myers

IPC分类号： G06F19/12 ,  G06F19/18

摘要： The present disclosure provides a computer implemented method. The method includes using a computer processor to perform the operations of constructing a nucleic acid mutation interaction network based upon nucleic acid pair-level interactions of a genetic sample scored under at least one disease model. The method further includes performing a thresholding and binarization process on the nucleic acid pair interactions to derive an interaction network. The method further includes testing pairs of pathways of the interaction network for either between pathway model (BPM) or within pathway model (WPM) enrichment of nucleic acid-nucleic acid mutation pair interaction. The method additionally includes outputting nucleic acid-nucleic acid mutation pair interaction data.