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    PHARMACEUTICAL COMPOSITIONS
    1.
    发明申请
    PHARMACEUTICAL COMPOSITIONS 审中-公开
    药物组合物

    公开(公告)号：US20100266645A1

    公开(公告)日：2010-10-21

    申请号：US12808204

    申请日：2008-12-16

    申请人： Alfred Liang ,  Frank Matthews ,  Garth Boehm ,  Joseph Stauffer

    发明人： Alfred Liang ,  Frank Matthews ,  Garth Boehm ,  Joseph Stauffer

    IPC分类号： A61K31/485 ,  A61K9/00 ,  A61P25/04

    CPC分类号： A61K9/16 ,  A61K9/5078 ,  A61K31/485 ,  A61K2300/00

    摘要： Provided herein are formulations and methods for treating pain in human beings. Also provide are optimal ratios at which an opioid and an opioid antagonist may be combined for administration to humans such that the opioid activity is inhibited. These ratios may also be used to formulate compositions containing both an opioid and an opioid antagonist within a single pharmaceutical dosing unit.

    摘要翻译： 本文提供了用于治疗人类疼痛的制剂和方法。 还提供了阿片样物质和阿片样物质拮抗剂可以组合用于给予人类以使阿片样物质活性受到抑制的最佳比例。 这些比例也可用于在单个药物给药单元内配制含有阿片样物质和阿片样物质拮抗剂的组合物。

    Sustained-Release Opioid Formulations and Methods of Use
    2.
    发明申请
    Sustained-Release Opioid Formulations and Methods of Use 审中-公开
    持续释放阿片样物质的配方和使用方法

    公开(公告)号：US20130072514A1

    公开(公告)日：2013-03-21

    申请号：US13413334

    申请日：2012-03-06

    申请人： Garth Boehm ,  Alfred Liang

    发明人： Garth Boehm ,  Alfred Liang

    IPC分类号： A61K31/485 ,  A61P25/04

    CPC分类号： A61K9/5084 ,  A61K9/5026 ,  A61K9/5047 ,  A61K9/5078 ,  A61K31/485

    摘要： The invention combines two different subunits with different release profiles in novel sustained-release oral dosage forms. In particular, the oral dosage forms include a subunit that comprises an opioid analgesic and a sustained-release material, wherein the dissolution rate in-vitro of the subunit, when measured by the standard USP Drug Release test of U.S. Pharmacopeia XXVI (2003) , is less than about 10% within about 6 hours and at least about 60% within about 24 hours; less than about 10% within about 8 hours and at least about 60% within about 24 hours; or less than about 10% within about 12 hours and at least about 60% within about 24 hours; the dosage form providing a duration of therapeutic effect of about 24 hours.

    摘要翻译： 本发明在新的持续释放口服剂型中组合了具有不同释放特征的两种不同亚基。 特别地，口服剂型包括包含阿片类镇痛药和缓释材料的亚基，其中当通过US Pharmacopeia XXVI（2003）的标准USP药物释放试验测量时，亚单位的体外溶出速率< 在约6小时内小于约10％，在约24小时内小于约60％; 在约8小时内小于约10％，在约24小时内至少约60％; 在约12小时内小于约10％，在约24小时内至少约60％; 所述剂型提供约24小时的治疗效果的持续时间。

    Pharmaceutical Composition
    8.
    发明申请
    Pharmaceutical Composition 审中-公开
    药物组成

    公开(公告)号：US20120121667A1

    公开(公告)日：2012-05-17

    申请号：US13357723

    申请日：2012-01-25

    申请人： Alfred Liang ,  Frank Matthews ,  Garth Boehm ,  Lijuan Tang ,  Frank Johnson ,  Joseph Stauffer

    发明人： Alfred Liang ,  Frank Matthews ,  Garth Boehm ,  Lijuan Tang ,  Frank Johnson ,  Joseph Stauffer

    IPC分类号： A61K9/00 ,  A61K31/485 ,  A61P25/04

    CPC分类号： A61K31/485 ,  A61K9/0002 ,  A61K9/4808 ,  A61K9/5026 ,  A61K9/5078

    摘要： Provided herein are pharmaceutical compositions comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions are also demonstrated.

    摘要翻译： 本文提供了包含拮抗剂，激动剂，密封涂层和螯合聚合物的药物组合物，其中所述拮抗剂，激动剂，密封剂涂层和至少一种螯合聚合物都是单一单元的组分，并且其中所述密封涂层形成 层将拮抗剂与激动剂彼此物理分离。 还提供了制备这种药物组合物的方法。 还证明了使用这种组合物治疗疼痛的方法。

    PHARMACEUTICAL COMPOSITION
    9.
    发明申请
    PHARMACEUTICAL COMPOSITION 审中-公开
    药物组合物

    公开(公告)号：US20100151014A1

    公开(公告)日：2010-06-17

    申请号：US12336418

    申请日：2008-12-16

    申请人： Alfred Liang ,  Frank Matthews ,  Garth Boehm ,  Lijuan Tang ,  Frank Johnson ,  Joseph Stauffer

    发明人： Alfred Liang ,  Frank Matthews ,  Garth Boehm ,  Lijuan Tang ,  Frank Johnson ,  Joseph Stauffer

    IPC分类号： A61K9/52 ,  A61P25/04

    CPC分类号： A61K31/485 ,  A61K9/0002 ,  A61K9/4808 ,  A61K9/5026 ,  A61K9/5078

    摘要： Provided herein are pharmaceutical compositions comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions are also demonstrated.

    摘要翻译： 本文提供的药物组合物包含拮抗剂，激动剂，密封涂层和螯合聚合物，其中所述拮抗剂，激动剂，密封剂涂层和至少一种螯合聚合物都是单一单元的组分，并且其中所述密封涂层形成 层将拮抗剂与激动剂彼此物理分离。 还提供了制备这种药物组合物的方法。 还证明了使用这种组合物治疗疼痛的方法。