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公开(公告)号：US07700097B2
公开(公告)日：2010-04-20
申请号：US10880320
申请日：2004-06-28
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/00 , C07K16/18 , C07K16/2851 , C07K16/30 , C07K2317/24 , C07K2317/52 , C07K2317/53 , C07K2317/622 , C07K2317/624 , C07K2319/00
摘要： The instant invention describes methods of separating or preferentially synthesizing dimers which are linked via at least one interchain disulfide linkage from dimers which are not linked via at least one interchain disulfide linkage from a mixture comprising the two types of polypeptide dimers. These forms can be separated from each other using hydrophobic interaction chromatography. In addition, the invention pertains to connecting peptides that result in the preferential biosynthesis of dimers that are linked via at least one interchain disulfide linkage or that are not linked via at least one interchain disulfide linkage. The invention also pertains to compositions in which a majority of the dimers are linked via at least one interchain disulfide linkage or are not linked via at least one interchain disulfide linkage. The invention still further pertains to novel binding molecules, e.g., comprising connecting peptides of the invention.
摘要翻译： 本发明描述了分离或优先合成二聚体的方法，二聚体通过至少一个链间二硫键连接，二聚体不通过至少一个链间二硫键与包含两种类型的多肽二聚体的混合物连接。 这些形式可以使用疏水相互作用色谱法彼此分离。 此外，本发明涉及连接导致通过至少一个链间二硫键连接或不通过至少一个链间二硫键连接的二聚体的优先生物合成的肽。 本发明还涉及其中大多数二聚体通过至少一个链间二硫键连接或不通过至少一个链间二硫键连接的组合物。 本发明还涉及新颖的结合分子，例如包含连接本发明的肽。
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公开(公告)号：US20050163783A1
公开(公告)日：2005-07-28
申请号：US10880320
申请日：2004-06-28
申请人： Gary Braslawsky , Scott Glaser , Tzung-Horng Yang , Jennifer Hopp , Paul Chinn
发明人： Gary Braslawsky , Scott Glaser , Tzung-Horng Yang , Jennifer Hopp , Paul Chinn
IPC分类号： A61K39/00 , C07K16/00 , C07K16/18 , C07K16/28 , C07K16/30 , C12N15/62 , A61K39/395 , C07H21/04 , C12N5/06
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/00 , C07K16/18 , C07K16/2851 , C07K16/30 , C07K2317/24 , C07K2317/52 , C07K2317/53 , C07K2317/622 , C07K2317/624 , C07K2319/00
摘要： The instant invention describes methods of separating or preferentially synthesizing dimers which are linked via at least one interchain disulfide linkage from dimers which are not linked via at least one interchain disulfide linkage from a mixture comprising the two types of polypeptide dimers. These forms can be separated from each other using hydrophobic interaction chromatography. In addition, the invention pertains to connecting peptides that result in the preferential biosynthesis of dimers that are linked via at least one interchain disulfide linkage or that are not linked via at least one interchain disulfide linkage. The invention also pertains to compositions in which a majority of the dimers are linked via at least one interchain disulfide linkage or are not linked via at least one interchain disulfide linkage. The invention still further pertains to novel binding molecules, e.g., comprising connecting peptides of the invention.
摘要翻译： 本发明描述了分离或优先合成二聚体的方法，二聚体通过至少一个链间二硫键连接，二聚体不通过至少一个链间二硫键与包含两种类型的多肽二聚体的混合物连接。 这些形式可以使用疏水相互作用色谱法彼此分离。 此外，本发明涉及连接导致通过至少一个链间二硫键连接或不通过至少一个链间二硫键连接的二聚体的优先生物合成的肽。 本发明还涉及其中大多数二聚体通过至少一个链间二硫键连接或不通过至少一个链间二硫键连接的组合物。 本发明还涉及新颖的结合分子，例如包含连接本发明的肽。
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