公开(公告)号：US20240360435A1

公开(公告)日：2024-10-31

申请号：US18771684

申请日：2024-07-12

Applicant: Gen-Probe Incorporated

Inventor： Kui GAO ,  Jijumon CHELLISERRY ,  Jeffrey LINNEN

IPC: C12N15/10 ,  C12Q1/6806 ,  C12Q1/70

CPC classification number: C12N15/1003 ,  C12Q1/6806 ,  C12Q1/70 ,  Y02A50/30

Abstract: Disclosed herein are lysis reagents for lysing red blood cells, thereby releasing an analyte, such as RNA from a host or pathogen, in a form suitable for analysis. The reagent includes at least a buffer, a detergent and one or both of a chloride containing salt and an anti-coagulant. The reagent serves to lyse blood cells, protect the released analyte from degradation in the lysate, and is compatible with subsequent steps for analysis of the analyte such as target capture, amplification, detection, or sequencing.