公开(公告)号：US11931401B2

公开(公告)日：2024-03-19

申请号：US17239289

申请日：2021-04-23

申请人： GeneCraft Inc.

发明人： Suk Chul Bae ,  Jung Won Lee ,  You Soub Lee

IPC分类号： A61K38/17 ,  A61K31/436 ,  A61K31/519 ,  A61K47/46 ,  A61P35/00 ,  C07K14/47 ,  C12N7/00

CPC分类号： A61K38/17 ,  A61K31/436 ,  A61K31/519 ,  A61K38/1709 ,  A61K47/46 ,  A61P35/00 ,  C07K14/4702 ,  C12N7/00 ,  C12N2750/14143

摘要： In the present invention, it was confirmed that the modified protein in which the 356th serine of Runx3 is substituted with alanine has an increased activity of maintaining the complex with Brd2 by more than 10 times compared to the wild-type Runx3, and the apoptosis effect is improved in various cancer cell lines compared to the wild-type Runx3. Therefore, the modified protein in which the 356th serine of Runx3 is substituted with an amino acid that cannot be phosphorylated by a kinase of the present invention, the polynucleotide coding thereof, the vector carrying the polynucleotide, or the virus or cell transformed with the vector can be used as a therapeutic agent for various cancers.