公开(公告)号：US10478400B2

公开(公告)日：2019-11-19

申请号：US15852125

申请日：2017-12-22

Applicant: Genentech, Inc.

Inventor： Sanjeev Kothari ,  Priscilla Mantik ,  Alexander Mauerer ,  Hamid Rezaei

IPC: A61K9/20 ,  A61K9/28 ,  A61K31/4523 ,  A61J3/10

Abstract: The present disclosure relates generally to rapid-release pharmaceutical dosage unit tablets containing a drug that is an inhibitor of the mitogen-activated protein kinase enzyme, a filler and a disintegrant, and to processes for forming the tablets. More specifically, the present disclosure relates to pharmaceutical dosage unit tablets containing cobimetinib, a least one filler, at least one lubricant and at least one disintegrant, and to methods for preparing the tablets from granules formed by dry granulation.

公开(公告)号：US20200085749A1

公开(公告)日：2020-03-19

申请号：US16685284

申请日：2019-11-15

Applicant: Genentech, Inc.

Inventor： Sanjeev Kothari ,  Priscilla Mantik ,  Alexander Mauerer ,  Hamid Rezaei

IPC: A61K9/20 ,  A61K9/16 ,  A61K31/437 ,  A61K45/06 ,  A61K9/28 ,  A61K31/4523 ,  A61J3/10

Abstract: The present disclosure relates generally to rapid-release pharmaceutical dosage unit tablets containing a drug that is an inhibitor of the mitogen-activated protein kinase enzyme, a filler and a disintegrant, and to processes for forming the tablets. More specifically, the present disclosure relates to pharmaceutical dosage unit tablets containing cobimetinib, a least one filler, at least one lubricant and at least one disintegrant, and to methods for preparing the tablets from granules formed by dry granulation.

公开(公告)号：US20180116966A1

公开(公告)日：2018-05-03

申请号：US15852125

申请日：2017-12-22

Applicant: Genentech, Inc.

Inventor： Sanjeev Kothari ,  Priscilla Mantik ,  Alexander Mauerer ,  Hamid Rezaei

IPC: A61K9/20 ,  A61K9/28 ,  A61J3/10

CPC classification number: A61K9/2095 ,  A61J3/10 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2077 ,  A61K9/284 ,  A61K31/437 ,  A61K31/4523 ,  A61K45/06 ,  A61K2300/00

Abstract: The present disclosure relates generally to rapid-release pharmaceutical dosage unit tablets containing a drug that is an inhibitor of the mitogen-activated protein kinase enzyme, a filler and a disintegrant, and to processes for forming the tablets. More specifically, the present disclosure relates to pharmaceutical dosage unit tablets containing cobimetinib, a least one filler, at least one lubricant and at least one disintegrant, and to methods for preparing the tablets from granules formed by dry granulation.