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1.发明授权公开(公告)号：US10478400B2
公开(公告)日：2019-11-19
申请号：US15852125
申请日：2017-12-22
Applicant: Genentech, Inc.
Inventor： Sanjeev Kothari , Priscilla Mantik , Alexander Mauerer , Hamid Rezaei
IPC: A61K9/20 , A61K9/28 , A61K31/4523 , A61J3/10
Abstract: The present disclosure relates generally to rapid-release pharmaceutical dosage unit tablets containing a drug that is an inhibitor of the mitogen-activated protein kinase enzyme, a filler and a disintegrant, and to processes for forming the tablets. More specifically, the present disclosure relates to pharmaceutical dosage unit tablets containing cobimetinib, a least one filler, at least one lubricant and at least one disintegrant, and to methods for preparing the tablets from granules formed by dry granulation.
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公开(公告)号：US20160152575A1
公开(公告)日：2016-06-02
申请号：US15018636
申请日：2016-02-08
Applicant: Genentech, Inc.
Inventor： Paroma Chakravarty , Sanjeev Kothari , Francis Gosselin , Scott J. Savage , Jeffrey Stults
IPC: C07D239/70
CPC classification number: C07D239/70 , A61K31/517 , C07D403/04
Abstract: Disclosed is (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one monohydrochloride, forms, formulations, pharmaceutical compositions, processes of manufacturing and methods of use thereof.
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Patent Agency Ranking
3.发明授权Amorphous form of an AKT inhibiting pyrimidinyl-cyclopentane compound, compositions and methods thereof 有权AKT抑制嘧啶基 - 环戊烷化合物的无定形形式，其组合物和方法公开(公告)号：US09290458B2
公开(公告)日：2016-03-22
申请号：US14401092
申请日：2013-05-17
Applicant: Genentech, Inc.
Inventor： Paroma Chakravarty , Sanjeev Kothari , Francis Gosselin , Scott J. Savage , Jeffrey Stults
IPC: C07D239/70 , A61K31/496 , C07D403/04 , A61K31/517
CPC classification number: C07D239/70 , A61K31/517 , C07D403/04
Abstract: Disclosed is (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one monohydrochloride, forms, formulations, pharmaceutical compositions, processes of manufacturing and methods of use thereof.
Abstract translation: 公开了（S）-2-（4-氯苯基）-1-（4 - （（5R，7R）-7-羟基-5-甲基-6,7-二氢-5H-环戊二烯并[d] 哌啶-1-基）-3-（异丙基氨基）丙-1-酮单盐酸盐，形式，制剂，药物组合物，制备方法及其使用方法。
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4.发明授权Crystalline and mesomorphous forms of an AKT inhibiting pyrimidinyl-cyclopentane compound, compositions and methods thereof 有权AKT抑制嘧啶基 - 环戊烷化合物的结晶和介晶形式，其组合物和方法公开(公告)号：US09505725B2
公开(公告)日：2016-11-29
申请号：US15018636
申请日：2016-02-08
Applicant: Genentech, Inc.
Inventor： Paroma Chakravarty , Sanjeev Kothari , Francis Gosselin , Scott J. Savage , Jeffrey Stults
IPC: C07D239/70 , A61K31/496 , C07D403/04 , A61K31/517
CPC classification number: C07D239/70 , A61K31/517 , C07D403/04
Abstract: Disclosed is (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one monohydrochloride, forms, formulations, pharmaceutical compositions, processes of manufacturing and methods of use thereof.
Abstract translation: 公开了（S）-2-（4-氯苯基）-1-（4 - （（5R，7R）-7-羟基-5-甲基-6,7-二氢-5H-环戊二烯并[d] 哌啶-1-基）-3-（异丙基氨基）丙-1-酮单盐酸盐，形式，制剂，药物组合物，制备方法及其使用方法。
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公开(公告)号：US20200085749A1
公开(公告)日：2020-03-19
申请号：US16685284
申请日：2019-11-15
Applicant: Genentech, Inc.
Inventor： Sanjeev Kothari , Priscilla Mantik , Alexander Mauerer , Hamid Rezaei
IPC: A61K9/20 , A61K9/16 , A61K31/437 , A61K45/06 , A61K9/28 , A61K31/4523 , A61J3/10
Abstract: The present disclosure relates generally to rapid-release pharmaceutical dosage unit tablets containing a drug that is an inhibitor of the mitogen-activated protein kinase enzyme, a filler and a disintegrant, and to processes for forming the tablets. More specifically, the present disclosure relates to pharmaceutical dosage unit tablets containing cobimetinib, a least one filler, at least one lubricant and at least one disintegrant, and to methods for preparing the tablets from granules formed by dry granulation.
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公开(公告)号：US20180116966A1
公开(公告)日：2018-05-03
申请号：US15852125
申请日：2017-12-22
Applicant: Genentech, Inc.
Inventor： Sanjeev Kothari , Priscilla Mantik , Alexander Mauerer , Hamid Rezaei
CPC classification number: A61K9/2095 , A61J3/10 , A61K9/1623 , A61K9/1652 , A61K9/2018 , A61K9/2054 , A61K9/2077 , A61K9/284 , A61K31/437 , A61K31/4523 , A61K45/06 , A61K2300/00
Abstract: The present disclosure relates generally to rapid-release pharmaceutical dosage unit tablets containing a drug that is an inhibitor of the mitogen-activated protein kinase enzyme, a filler and a disintegrant, and to processes for forming the tablets. More specifically, the present disclosure relates to pharmaceutical dosage unit tablets containing cobimetinib, a least one filler, at least one lubricant and at least one disintegrant, and to methods for preparing the tablets from granules formed by dry granulation.
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7.发明申请AMORPHOUS FORM OF AN AKT INHIBITING PYRIMIDINYL-CYCLOPENTANE COMPOUND, COMPOSITIONS AND METHODS THEREOF 有权AKT抑制吡咯烷基环丙烷化合物的非晶形式，其组合物及其方法公开(公告)号：US20150274677A1
公开(公告)日：2015-10-01
申请号：US14401092
申请日：2012-05-17
Applicant: Genentech, Inc.
Inventor： Paroma Chakravarty , Sanjeev Kothari , Francis Gosselin , Scott J. Savage , Jeffrey Stults
IPC: C07D239/70
CPC classification number: C07D239/70 , A61K31/517 , C07D403/04
Abstract: Disclosed is (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one monohydrochloride, forms, formulations, pharmaceutical compositions, processes of manufacturing and methods of use thereof.
Abstract translation: 公开了（S）-2-（4-氯苯基）-1-（4 - （（5R，7R）-7-羟基-5-甲基-6,7-二氢-5H-环戊二烯并[d] 哌啶-1-基）-3-（异丙基氨基）丙-1-酮单盐酸盐，形式，制剂，药物组合物，制备方法及其使用方法。
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