公开(公告)号：US09994646B2

公开(公告)日：2018-06-12

申请号：US14735024

申请日：2015-06-09

Applicant: Genentech, Inc.

Inventor： Erin H. Christensen ,  Dan L. Eaton ,  Andrew C. Vendel ,  Bernd Wranik

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/32

CPC classification number: C07K16/468 ,  C07K16/283 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/53 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/73

Abstract: The invention provides engineered protein complexes constructed using a coiled coil and/or a tether and methods for making, using, and purifying such complexes, such as multispecific antibodies or other multispecific Fc containing complexes.