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公开(公告)号：US09994646B2
公开(公告)日：2018-06-12
申请号：US14735024
申请日：2015-06-09
Applicant: Genentech, Inc.
Inventor： Erin H. Christensen , Dan L. Eaton , Andrew C. Vendel , Bernd Wranik
CPC classification number: C07K16/468 , C07K16/283 , C07K16/2863 , C07K16/32 , C07K2317/31 , C07K2317/51 , C07K2317/53 , C07K2317/73 , C07K2317/92 , C07K2319/00 , C07K2319/73
Abstract: The invention provides engineered protein complexes constructed using a coiled coil and/or a tether and methods for making, using, and purifying such complexes, such as multispecific antibodies or other multispecific Fc containing complexes.
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公开(公告)号：US09688758B2
公开(公告)日：2017-06-27
申请号：US14455189
申请日：2014-08-08
Applicant: Genentech, Inc.
Inventor： Bernd Wranik , Dan L. Eaton , Erin H. Christensen , Jiansheng Wu
CPC classification number: C07K16/28 , C07K16/00 , C07K16/18 , C07K16/22 , C07K16/24 , C07K16/26 , C07K2317/31 , C07K2317/515 , C07K2317/53 , C07K2317/622 , C07K2317/64
Abstract: The invention provides engineered heteromultimeric protein complexes constructed using one, two, or three tethers and methods for making, using, and purifying such complexes, such as antibodies with different binding properties.
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公开(公告)号：US20150166631A1
公开(公告)日：2015-06-18
申请号：US14451764
申请日：2014-08-05
Applicant: GENENTECH, INC.
Inventor： Hilary Clark , Daniel L. Eaton , Bernd Wranik , Wenjun Ouyang , Lino Gonzalez , Austin L. Gurney
IPC: C07K14/705 , C07K16/28 , G01N33/574 , G01N33/68
CPC classification number: C07K14/705 , A61K38/00 , C07K16/28 , C07K2319/00 , G01N33/5011 , G01N33/57407 , G01N33/6893 , G01N2333/705 , G01N2800/065 , G01N2800/24 , G01N2800/245
Abstract: The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of immune related disease.
Abstract translation: 本发明涉及含有新蛋白质的组合物和使用这些组合物来诊断和治疗免疫相关疾病的方法。
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