公开(公告)号：US10100319B2

公开(公告)日：2018-10-16

申请号：US14549962

申请日：2014-11-21

Applicant: Genentech, Inc.

Inventor： Laetitia Malphettes ,  Andrew Snowden ,  Inn H. Yuk

IPC: C12N15/67 ,  C12N15/63

Abstract: The invention provides compositions and methods for regulating intracellular osmolarity in cells, e.g., in cultured cells, including in cultured cells in bioreactors. The invention provides nucleic acids comprising at least one osmo-responsive transcriptional regulatory element (OR-TRE), and cells, vectors, products of manufacture, artificial organs or implants and the like containing an osmo-responsive transcriptional regulatory element (OR-TRE).

公开(公告)号：US11279939B2

公开(公告)日：2022-03-22

申请号：US16143189

申请日：2018-09-26

Applicant: Genentech, Inc.

Inventor： Laetitia Malphettes ,  Andrew Snowden ,  Inn H. Yuk

IPC: C12N15/67 ,  C12N15/63

Abstract: The invention provides compositions and methods for regulating intracellular osmolarity in cells, e.g., in cultured cells, including in cultured cells in bioreactors. The invention provides nucleic acids comprising at least one osmo-responsive transcriptional regulatory element (OR-TRE), and cells, vectors, products of manufacture, artificial organs or implants and the like containing an osmo-responsive transcriptional regulatory element (OR-TRE).

公开(公告)号：US20190127741A1

公开(公告)日：2019-05-02

申请号：US16143189

申请日：2018-09-26

Applicant: Genentech, Inc.

Inventor： Laetitia MALPHETTES ,  Andrew Snowden ,  Inn H. Yuk

IPC: C12N15/67 ,  C12N15/63

Abstract: The invention provides compositions and methods for regulating intracellular osmolarity in cells, e.g., in cultured cells, including in cultured cells in bioreactors. The invention provides nucleic acids comprising at least one osmo-responsive transcriptional regulatory element (OR-TRE), and cells, vectors, products of manufacture, artificial organs or implants and the like containing an osmo-responsive transcriptional regulatory element (OR-TRE).