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公开(公告)号：US09945858B2
公开(公告)日：2018-04-17
申请号：US15065615
申请日：2016-03-09
Applicant: Genentech, Inc.
Inventor： Feny Gunawan , Yi-Chun Hsiao , Denise C. Krawitz , Margaret S. Lin , Martin Vanderlaan , Rajesh Vij , Inn H. Yuk , Judith Zhu-Shimoni
IPC: G01N33/577 , G01N33/573 , C07K16/40
CPC classification number: G01N33/573 , C07K16/40 , C07K2317/33 , C07K2317/565 , G01N33/577 , G01N2333/918 , G01N2333/92 , G01N2500/10
Abstract: Monoclonal and polyclonal antibodies that bind hamster phospholipase B-like 2 are provided. Also provided are methods for detecting and quantifying hamster phospholipase B-like 2, for example, in recombinant polypeptide preparations, as well as kits for carrying out such methods. Methods of screening or selecting host cell lines or recombinant polypeptide-expressing cell lines that express low levels of hamster phospholipase B-like 2 are also provided.
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公开(公告)号：US10894940B2
公开(公告)日：2021-01-19
申请号：US16218323
申请日：2018-12-12
Applicant: GENENTECH, INC.
Inventor： Dinesh Baskar , Jenny Hsiung , Woon-Lam Susan Leung , Inn H. Yuk
Abstract: An apparatus and method to maintain pH within a range conducive for cell growth in a bicarbonate-containing cell culture system without the addition of base. The method relies on the gas transfer characteristics of the bioreactor system to modulate the CO2 transfer to and from the cell culture such that the pH of the cell culture can be maintained within a desired range.
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公开(公告)号：US10100319B2
公开(公告)日：2018-10-16
申请号：US14549962
申请日：2014-11-21
Applicant: Genentech, Inc.
Inventor： Laetitia Malphettes , Andrew Snowden , Inn H. Yuk
Abstract: The invention provides compositions and methods for regulating intracellular osmolarity in cells, e.g., in cultured cells, including in cultured cells in bioreactors. The invention provides nucleic acids comprising at least one osmo-responsive transcriptional regulatory element (OR-TRE), and cells, vectors, products of manufacture, artificial organs or implants and the like containing an osmo-responsive transcriptional regulatory element (OR-TRE).
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公开(公告)号：US11939559B2
公开(公告)日：2024-03-26
申请号：US17148190
申请日：2021-01-13
Applicant: Genentech, Inc.
Inventor： Dinesh Baskar , Jenny Hsiung , Woon-Lam Susan Leung , Inn H. Yuk
CPC classification number: C12M23/14 , C12M23/28 , C12M27/16 , C12M29/10 , C12M29/20 , C12M41/12 , C12M41/26 , C12M41/32 , C12M41/48 , C12N5/0018 , C12N2500/05
Abstract: An apparatus and method to maintain pH within a range conducive for cell growth in a bicarbonate-containing cell culture system without the addition of base. The method relies on the gas transfer characteristics of the bioreactor system to modulate the CO2 transfer to and from the cell culture such that the pH of the cell culture can be maintained within a desired range.
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公开(公告)号：US10190084B2
公开(公告)日：2019-01-29
申请号：US14480366
申请日：2014-09-08
Applicant: Genentech, Inc.
Inventor： Dinesh Baskar , Jenny Hsiung , Woon-Lam Susan Leung , Inn H. Yuk
Abstract: An apparatus and method to maintain pH within a range conducive for cell growth in a bicarbonate-containing cell culture system without the addition of base. The method relies on the gas transfer characteristics of the bioreactor system to modulate the CO2 transfer to and from the cell culture such that the pH of the cell culture can be maintained within a desired range.
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Patent Agency Ranking
公开(公告)号：US10788494B2
公开(公告)日：2020-09-29
申请号：US15914094
申请日：2018-03-07
Applicant: Genentech, Inc.
Inventor： Feny Gunawan , Yi-Chun Hsiao , Denise C. Krawitz , Margaret S. Lin , Martin Vanderlaan , Rajesh Vij , Inn H. Yuk , Judith Zhu-Shimoni
IPC: C07K16/40 , G01N33/573 , G01N33/577
Abstract: Monoclonal and polyclonal antibodies that bind hamster phospholipase B-like 2 are provided. Also provided are methods for detecting and quantifying hamster phospholipase B-like 2, for example, in recombinant polypeptide preparations, as well as kits for carrying out such methods. Methods of screening or selecting host cell lines or recombinant polypeptide-expressing cell lines that express low levels of hamster phospholipase B-like 2 are also provided.
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7.发明申请公开(公告)号：US20180364236A1
公开(公告)日：2018-12-20
申请号：US15914099
申请日：2018-03-07
Applicant: Genentech, Inc.
Inventor： Feny Gunawan , Yi-Chun Hsiao , Denise C. Krawitz , Margaret S. Lin , Martin Vanderlaan , Rajesh Vij , Inn H. Yuk , Judith Zhu-Shimoni
IPC: G01N33/573 , G01N33/577 , C07K16/40
Abstract: Monoclonal and polyclonal antibodies that bind hamster phospholipase B-like 2 are provided. Also provided are methods for detecting and quantifying hamster phospholipase B-like 2, for example, in recombinant polypeptide preparations, as well as kits for carrying out such methods. Methods of screening or selecting host cell lines or recombinant polypeptide-expressing cell lines that express low levels of hamster phospholipase B-like 2 are also provided.
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8.发明申请COMPOSITIONS AND METHODS FOR DETECTING AND QUANTIFYING HOST CELL PROTEIN IN CELL LINES AND RECOMBINANT POLYPEPTIDE PRODUCTS 审中-公开用于检测和定量细胞系和重组多肽产物中的宿主细胞蛋白的组合物和方法公开(公告)号：US20160320391A1
公开(公告)日：2016-11-03
申请号：US15065615
申请日：2016-03-09
Applicant: Genentech, Inc.
Inventor： Feny Gunawan , Yi-Chun Hsiao , Denise C. Krawitz , Margaret S. Lin , Martin Vanderlaan , Rajesh Vij , Inn H. Yuk , Judith Zhu-Shimoni
IPC: G01N33/573 , C07K16/40 , G01N33/577
CPC classification number: G01N33/573 , C07K16/40 , C07K2317/33 , C07K2317/565 , G01N33/577 , G01N2333/918 , G01N2333/92 , G01N2500/10
Abstract: Monoclonal and polyclonal antibodies that bind hamster phospholipase B-like 2 are provided. Also provided are methods for detecting and quantifying hamster phospholipase B-like 2, for example, in recombinant polypeptide preparations, as well as kits for carrying out such methods. Methods of screening or selecting host cell lines or recombinant polypeptide-expressing cell lines that express low levels of hamster phospholipase B-like 2 are also provided.
Abstract translation: 提供了结合仓鼠磷脂酶B样2的单克隆和多克隆抗体。 还提供了用于检测和定量仓鼠磷脂酶B样2的方法，例如在重组多肽制备中，以及用于进行这些方法的试剂盒。 还提供筛选或选择表达低水平仓鼠磷脂酶B样2的宿主细胞系或重组多肽表达细胞系的方法。
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公开(公告)号：US11519912B2
公开(公告)日：2022-12-06
申请号：US15914099
申请日：2018-03-07
Applicant: Genentech, Inc.
Inventor： Feny Gunawan , Yi-Chun Hsiao , Denise C. Krawitz , Margaret S. Lin , Martin Vanderlaan , Rajesh Vij , Inn H. Yuk , Judith Zhu-Shimoni
IPC: G01N33/577 , G01N33/573 , C07K16/40
Abstract: Monoclonal and polyclonal antibodies that bind hamster phospholipase B-like 2 are provided. Also provided are methods for detecting and quantifying hamster phospholipase B-like 2, for example, in recombinant polypeptide preparations, as well as kits for carrying out such methods. Methods of screening or selecting host cell lines or recombinant polypeptide-expressing cell lines that express low levels of hamster phospholipase B-like 2 are also provided.
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公开(公告)号：US11279939B2
公开(公告)日：2022-03-22
申请号：US16143189
申请日：2018-09-26
Applicant: Genentech, Inc.
Inventor： Laetitia Malphettes , Andrew Snowden , Inn H. Yuk
Abstract: The invention provides compositions and methods for regulating intracellular osmolarity in cells, e.g., in cultured cells, including in cultured cells in bioreactors. The invention provides nucleic acids comprising at least one osmo-responsive transcriptional regulatory element (OR-TRE), and cells, vectors, products of manufacture, artificial organs or implants and the like containing an osmo-responsive transcriptional regulatory element (OR-TRE).
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