公开(公告)号：US20190144428A1

公开(公告)日：2019-05-16

申请号：US16250230

申请日：2019-01-17

Applicant: Genentech, Inc.

Inventor： Vishal VERMA ,  Daniel SHORE ,  Matthew VOLGRAF ,  Anthony A. ESTRADA ,  Joseph LYSSIKATOS

IPC: C07D401/14 ,  C07D403/14 ,  C07D403/12 ,  C07D405/14

CPC classification number: C07D401/14 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14

Abstract: The invention is concerned with the compounds of formula I: and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.