公开(公告)号：US20230279067A1

公开(公告)日：2023-09-07

申请号：US18057604

申请日：2022-11-21

Applicant: Genentech, Inc.

Inventor： Yichin LIU ,  Christine Carine MOUSSION ,  Travis William BAINBRIDGE ,  lraj HOSSEINI ,  Gregory Alan LAZAR ,  Sivan COHEN ,  Christopher Charles KEMBALL ,  Jill M. SCHARTNER

IPC: C07K14/475 ,  A61K31/713 ,  A61K38/18 ,  A61K39/395 ,  C07K16/28

CPC classification number: C07K14/475 ,  A61K31/713 ,  A61K38/18 ,  A61K39/39541 ,  C07K16/2818 ,  C07K16/2827 ,  A61K2039/505

Abstract: The invention provides an effectorless immunoglobulin Fc protein, fusions of the effectorless Fc protein to a Flt3 ligand, and methods of using the same.

公开(公告)号：US20220289803A1

公开(公告)日：2022-09-15

申请号：US17664589

申请日：2022-05-23

Applicant: Genentech, Inc.

Inventor： Yichin LIU ,  Christine Carine MOUSSION ,  Travis William BAINBRIDGE ,  Iraj HOSSEINI ,  Gregory Alan LAZAR ,  Sivan COHEN ,  Christopher Charles KEMBALL ,  Jill M. SCHARTNER

IPC: C07K14/475 ,  A61K38/18 ,  A61K31/713 ,  A61K39/395 ,  C07K16/28

Abstract: The invention provides an effectoriess immunoglobulin Fc protein, fusions of the effectorless Fc protein to a Flt3 ligand, and methods of using the same.

公开(公告)号：US20220262458A1

公开(公告)日：2022-08-18

申请号：US17629327

申请日：2020-07-24

Applicant: Genentech, Inc.

Inventor： Yasin SENBABAOGLU ,  Christine Carine MOUSSION

IPC: G16B20/00 ,  G16B40/30

Abstract: Embodiments disclosed herein generally relate to classifying a tumor, based on gene expression data, as being neurally related or non-neurally related. The tumor may be classified using a machine-learning model, which may have been trained to differentiate gene-expression data associated with neuronal or neuroendocrine tumors from gene-expression data associated with non-neuronal and non-neuroendocrine tumors. Differential treatment and/or treatment recommendations may be provided based on the classification. First-line checkpoint blockade therapy may be used or recommended when a tumor is identified as being non-neurally related, and a combination therapy (e.g., initial chemotherapy and subsequent checkpoint blockade therapy) may be used or recommended when a tumor is identified as being neurally related.