公开(公告)号：US20240228638A1

公开(公告)日：2024-07-11

申请号：US18528122

申请日：2023-12-04

Applicant: Genentech, Inc.

Inventor： Michele Anne Grimbaldeston ,  Divya Mohan ,  Ahmed Yousuf ,  Christopher Brightling ,  Dorothy Sze-Wing Cheung ,  David Fong Choy

IPC: C07K16/28 ,  A61K39/00 ,  A61P11/00

CPC classification number: C07K16/2866 ,  A61P11/00 ,  A61K2039/505 ,  A61K2039/545

Abstract: The application describes a method of treating chronic obstructive pulmonary disease (COPD) in a patient comprising administering 476 mg of an ST2 antagonist to the patient on Day 1 of a treatment period. The application also describes methods of treating or preventing frequency of moderate to severe exacerbations in a patient having COPD comprising administering an effective amount of an ST2 antagonist to achieve a clinical improvement of at least 10%, at least 20%, at least 21%, at least 22%, at least 25%, at least 30%, at least 35%, at least 40% or at least 45% annualized exacerbation rate reduction than standard of care (SOC).