公开(公告)号：US20240109958A1

公开(公告)日：2024-04-04

申请号：US18537389

申请日：2023-12-12

Applicant: Genentech, Inc.

Inventor： Donald Scott KIRKPATRICK ,  James Thomas KOERBER ,  Christopher Williamson DAVIES

IPC: C07K16/18 ,  C07K16/00 ,  C40B30/04 ,  G01N33/68

CPC classification number: C07K16/18 ,  C07K16/005 ,  C40B30/04 ,  G01N33/6845 ,  C07K2317/20 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622

Abstract: Provided herein are antibodies that bind to a peptide of an N-terminally ubiquitinated polypeptide and methods of screening for such antibodies. Also provided herein are detection and enrichment methods using such antibodies for detecting or enriching a peptide of an N-terminally ubiquitinated polypeptide.

公开(公告)号：US20230192853A1

公开(公告)日：2023-06-22

申请号：US17640499

申请日：2020-09-03

Applicant: GENENTECH, INC. ,  F. Hoffmann-LA Roche AG

Inventor： James Thomas KOERBER ,  Alejandra Beatrice Urpi URRUTIA ,  Simon-Peter WILLIAMS ,  Christopher Williamson DAVIES ,  Shravan Kumar SRIRAMAN ,  Herman Singh GILL ,  James Richard KIEFER, Jr.

IPC: C07K16/28 ,  A61K51/10 ,  G01N33/574

CPC classification number: C07K16/2815 ,  A61K51/1027 ,  A61K51/1093 ,  G01N33/57492 ,  C07K2317/92 ,  C07K2317/569 ,  C07K2317/24 ,  C07K2317/22 ,  C07K2317/74

Abstract: Provided are CD8 binding agents comprising a VHH domain that specifically binds human CD8. Also provided are nucleic acids encoding such CD8 binding agents, vectors comprising such nucleic acids, host cells comprising same, and methods of making such CD8 binding agents. Also provided are CD8 binding agents having the VHH domain conjugated to a detectable label. Provided are methods of using such CD8 binding agents to detect CD8+ T cells, monitor disease progress, and monitor treatment progress in a subject having cancer, autoimmune disease or condition, transplant rejection or graft-versus-host disease.